Category
Emmanuelle joined the Senior Management Team at IDDO in December 2023. As Senior Operations and Development Manager, she provides leadership to programme management and operations activity across IDDO’s portfolio of infectious disease research themes and data repository. She also oversees the governance of the organisation, and supports its strategic development including funding, communications and partnerships.
Emmanuelle has an MRes in Molecular and Cellular Immunology with a specialisation in Virology from University Paul Sabatier in Toulouse, France. She carried out a PhD in genetics at the WCHG in Oxford, developing the first prenatal diagnosis for a severe congenital immune and skin disorder. She then moved to the MRC Functional Genomics Unit, working in neurosciences on new therapeutic pathways for aggressive forms of blood cancer in children, before joining the Department of Statistics.
In the past 10 years, she managed the strategies, operations, and governance of multidisciplinary programmes in cancer and infertility across experimental and computational biology, including building and leading new research and preclinical validation platforms in academia and the industry.
All Publications
Robotic Mouse
Bitoun, E., Oliver, P., & Davies, K. (2022). In Handbook of the Cerebellum and Cerebellar Disorders (pp. 1667-1684). Springer Nature.
ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair
Bitoun, E., Wells, D., Hinch, A., Moralli, D., Zhang, G., Jankowska, J., Donnelly, P., Green, C., & Myers, S. (2020). ELife, 9.
ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair
Wells, D., Bitoun, E., Moralli, D., Zhang, G., Hinch, A., Jankowska, J., Donnelly, P., Green, C., & Myers, S. (2020). Genetics and Genomics, 9.
Robotic Mouse
Bitoun, E., Oliver, P., & Davies, K. (2020). In Handbook of the Cerebellum and Cerebellar Disorders (pp. 1-18). Springer Nature.
A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination.
Li, R., Bitoun, E., Altemose, N., Davies, R., Davies, B., & Myers, S. (2019). Nature Communications, 1.
A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination
Li, R., Bitoun, E., Altemose, N., Davies, R., Davies, B., & Myers, S. (2019). Nature Communications, 10.
Genetic diversity and its unexpected impacts on recombination, genome evolution, speciation and sterility in mammals
Li, R., Bitoun, E., Altemose, N., Davies, R., Davies, B., & Myers, S. (2019). EUROPEAN JOURNAL OF HUMAN GENETICS, 27, 1073-1073.
A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination
Li, R., Bitoun, E., Altemose, N., Davies, R., Davies, B., & Myers, S. (2018). In bioRxiv.
A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
Altemose, N., Noor, N., Bitoun, E., Tumian, A., Imbeault, M., Chapman, J., Aricescu, A., & Myers, S. (2017). ELife, 6, e28383.
Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice
Davies, B., Hatton, E., Altemose, N., Hussin, J., Pratto, F., Zhang, G., Hinch, A., Moralli, D., Biggs, D., Diaz, R., Preece, C., Li, R., Bitoun, E., Brick, K., Green, C., Camerini-Otero, R., Myers, S., & Donnelly, P. (2016). Nature, 530(2016), 171-176.
A novel mouse model of a patient mucolipidosis II mutation recapitulates disease pathology.
Paton, L., Bitoun, E., Kenyon, J., Priestman, D., Oliver, P., Edwards, B., Platt, F., & Davies, K. (2014). The Journal of Biological Chemistry, 289(39), 26709-26721.
Robotic Mouse
Bitoun, E., Oliver, P., & Davies, K. (2013). In Handbook of the Cerebellum and Cerebellar Disorders (pp. 1481-1497). Springer Nature.
Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
Oliver, P., Finelli, M., Edwards, B., Bitoun, E., Butts, D., Becker, E., Cheeseman, M., Davies, K., & Davies, B. (2011). PLoS Genetics, 7(10).
AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development
Bitoun, E., Finelli, M., Oliver, P., Lee, S., & Davies, K. (2009). Journal of Neuroscience, 29(49), 15366-15374.
The robotic mouse: understanding the role of AF4, a cofactor of transcriptional elongation and chromatin remodelling, in purkinje cell function.
Bitoun, E., & Davies, K. (2009). Cerebellum (London, England), 8(3), 175-183.
PTPRR, cerebellum, and motor coordination.
Schmitt, I., Bitoun, E., & Manto, M. (2009). Cerebellum (London, England), 8(2), 71-73.
The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila.
Vereshchagina, N., Ramel, M.-C., Bitoun, E., & Wilson, C. (2008). Journal of Cell Science, 121(Pt 20), 3383-3392.
Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease.
Oliver, P., Bitoun, E., & Davies, K. (2007). Mammalian Genome : Official Journal of the International Mammalian Genome Society, 18(6-7), 412-424.
Keratitis–ichthyosis–deafness syndrome: disease expression and spectrum of connexin 26 (GJB2) mutations in 14 patients
Mazereeuw‐Hautier, J., Bitoun, E., Chevrant‐Breton, J., Man, S., Bodemer, C., Prins, C., Antille, C., Saurat, J., Atherton, D., Harper, J., Kelsell, D., & Hovnanian, A. (2007). British Journal of Dermatology, 156(5), 1015-1019.
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling.
Bitoun, E., Oliver, P., & Davies, K. (2007). Human Molecular Genetics, 16(1), 92-106.
LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum.
Ishida-Yamamoto, A., Deraison, C., Bonnart, C., Bitoun, E., Robinson, R., O’Brien, T., Wakamatsu, K., Ohtsubo, S., Takahashi, H., Hashimoto, Y., Dopping-Hepenstal, P., McGrath, J., Iizuka, H., Richard, G., & Hovnanian, A. (2005). The Journal of Investigative Dermatology, 124(2), 360-366.
Mediation of Af4 function in the cerebellum by Siah proteins
Bitoun, E., Oliver, P., & Davies, K. (2005). GENETICAL RESEARCH, 86(3), 238-238.
The robotic mouse: unravelling the function of AF4 in the cerebellum.
Bitoun, E., & Davies, K. (2005). Cerebellum (London, England), 4(4), 250-260.
Mediation of Af4 protein function in the cerebellum by Siah proteins.
Oliver, P., Bitoun, E., Clark, J., Jones, E., & Davies, K. (2004). Proc Natl Acad Sci U S A, 101(41), 14901-14906.
Mediation of Af4 protein function in the cerebellum by Siah proteins.
Oliver, P., Bitoun, E., Clark, J., Jones, E., & Davies, K. (2004). Proceedings of the National Academy of Sciences of the United States of America, 101(41), 14901-14906.