This living systematic review aims to provide an open, accessible and frequently updated resource summarising the characteristics of COVID-19 clinical trial registrations. Weekly search updates of the WHO International Clinical Trials Registry Platform (ICTRP) and source registries are being conducted. Data extraction by two reviewers of trial characteristic variables including categorisation of trial design, geographic location, intervention type and targets, level of evidence and intervention adaptability to low resource settings is being completed. Descriptive and thematic synthesise is in progress.
Preliminary results of the baseline search results (24 March 2020) identified 555 relevant registered clinical trial records. Of the 334 clinical trials assessing diagnostic methods, therapeutic and prophylactic strategies, 188 are currently open for recruitment of patients, healthy volunteers or healthcare workers in the context of COVID-19 and a further 146 are preparing to recruit. A searchable and interactive visualisation of the results database is being created, and will shortly be made openly available online and updated following continued weekly search updates. Furthermore, all project resources including the review protocol, REDCap database and associated variable and data dictionaries will be accessible.
This living systematic review will provide a useful resource for researchers in a rapidly evolving context. In the future, this sustained review will allow prioritisation of research targets for individual patient data meta-analysis.