This living systematic review aims to provide an open, accessible and frequently updated resource summarising the characteristics of COVID-19 clinical trial registrations. Weekly search updates of the WHO International Clinical Trials Registry Platform (ICTRP) and source registries are being conducted. Data extraction by two reviewers of trial characteristic variables including categorisation of trial design, geographic location, intervention type and targets, level of evidence and intervention adaptability to low resource settings is being completed. Descriptive and thematic syntheses is in progress.
Preliminary results of the baseline search on (3 April 2020) identified 728 relevant registered clinical trial records, of which 392 were open for recruitment of patients, health volunteers or healthcare workers at the time of search. Of the 728 trial records, 207 plan to assess a pharmacological intervention, 48 plan to assess an advanced therapy medicinal product and 39 plan to assess a diagnostic intervention.
In partnership with Exaptive, a searchable and interactive visualisation of the results database is now openly available online.
This living systematic review aims to provide a useful resource for researchers in a rapidly evolving context. In the future, this sustained review will allow prioritisation of research targets for individual patient data meta-analysis.