Living systematic review COVID-19

Coronavirus disease  COVID-19 Registered Clinical Trials 

Since the COVID-19 outbreak was identified in December 2019 in Wuhan, China, a strong response from the research community has been evident as observed in the proliferation of independent clinical trials assessing diagnostic methods, therapeutic and prophylactic strategies. Tools to distil the current research landscape by intervention, level of evidence, and those studies likely powered to address future research questions are essential.

screenshot of the tool

This living systematic review aims to provide an open, accessible and frequently updated resource summarising the characteristics of COVID-19 clinical trial registrations. Weekly search updates of the WHO International Clinical Trials Registry Platform (ICTRP) and source registries are being conducted. Data extraction by two reviewers of trial characteristic variables including categorisation of trial design, geographic location, intervention type and targets and level of evidence is being completed. Descriptive and thematic syntheses is in progress.

In partnership with Exaptive, a searchable and interactive visualisation of the results database is now openly available online.

This living systematic review aims to provide a useful resource for researchers in a rapidly evolving context. In the future, this sustained review will allow prioritisation of research targets for individual patient data meta-analysis.   

Associated data and publications

Read the living systematic review and the protocol for this work. The underlying data used for this tool and extended data including variables and data dictionaries are available here.