Dr Lucie Kafkova | Infectious Diseases Data Observatory

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Category

Research Support

Lucie

Kafkova

Acting programme manager for Malaria/WWARN

Lucie.kafkova@iddo.com

Research Theme

WWARN

Lucie Kafkova, a former Marie Curie Postdoctoral Fellow, recently joined IDDO to support the Neglected Tropical Disease portfolio team. Before this, she conducted ground-breaking research in Prof. Mathew Freeman's lab at the Sir William Dunn School of Pathology, developing novel methodology using unnatural amino acids to discover new substrates of human rhomboid protease RHBDL4.

Lucie earned her Ph.D. at the University at Buffalo under the guidance of Prof. Laurie Read, investigating arginine methylation in Trypanosoma brucei. Her academic journey began with a master's and bachelor's degree in the lab of Prof. Lukes in the Czech Republic, where she studied RNA editing in Trypanosoma brucei. Notably, Lucie was honoured with the Dean's Prize for both her master's and Ph.D. theses. Lucie is also a certified Professional Coach, showcasing her commitment to personal and professional development.

All Publications

Mechanism-based traps enable protease and hydrolase substrate discovery

Tang, S., Beattie, A., Kafkova, L., Petris, G., Huguenin-Dezot, N., Fiedler, M., Freeman, M., & Chin, J. (2022). Nature, 602, 701-707.

Trypanosoma brucei PRMT1 is a nucleic acid binding protein with a role in energy metabolism and the starvation stress response

Kafkova, L., Tu, C., Pazzo, K., Smith, K., Debler, E., Paul, K., Qu, J., & Read, L. (2018). MBio, 9(6).

The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex.

Kafková, L., Debler, E., Fisk, J., Jain, K., Clarke, S., & Read, L. (2016). The Journal of Biological Chemistry, 292(6), 2089-2100.

Architecture of the trypanosome RNA editing accessory complex, MRB1.

Ammerman, M., Downey, K., Hashimi, H., Fisk, J., Tomasello, D., Faktorová, D., Kafková, L., King, T., Lukes, J., & Read, L. (2012). Nucleic Acids Research, 40(12), 5637-5650.