An extensive, free tool library
Please do credit their use in your published work.
Literature reviews
• WWARN Clinical Trials Publication Library: a comprehensive, living systematic review of trials from 1946 to the present day. Includes data from over 400,000 patients across more than 90 countries.
• The Malaria in Pregnancy Library: includes published and unpublished literature from 1840 onwards, in all languages.
• The ACT & Parasite Clearance Review: detailed summary of all published studies using an artemisinin regimen.
• Ivermectin exposure in small children: systematic review of ivermectin exposure in children >15 kg.
• Chloroquine-resistant P. vivax systematic review.
• Primaquine review: comprehensive review of all published primaquine trials.
• Vivax library: data from over 300 clinical trials across 39 countries since 1960.
Safety
• Participant-reported safety data in antimalarial trials.
• Late antimalarial treatment failure: case management of trial patients failing first-line treatment.
• Safety assessment and reporting: adverse event and drug-reaction management.
• Acute haemolysis management: by field staff during primaquine clinical trials.
Misc.
• P. vivax drug efficacy protocol template: includes consent forms.
Artemisinin resistance
• WWARN artemisinin molecular surveyor: interactive map that summarises K13 prevalence across ~80 countries.
• ACT partner drug molecular surveyor: interactive map of P. falciparum pfmd1 and pfcrt gene locations over time.
• Sulphadoxine pyrimethamine (SP) molecular surveyor: interactive map of P. falciparum dhfr and dhps gene locations over time.
• Kelch markers toolkit: enables assessment of minimal essential information needed to pool k13 marker studies.
Partial drug resistance
• P. vivax drug efficacy protocol template: for investigating antimalarials against P. vivax infections. Includes consent forms.
• ACT partner drug molecular surveyor: interactive map of P. falciparum pfmd1 and pfcrt gene locations over time.
• Sulphadoxine pyrimethamine (SP) molecular surveyor: interactive map of P. falciparum dhfr and dhps gene locations over time.
Ex-vivo susceptibility
• Safety assessment and reporting: adverse event/drug reaction management.
• Artemisinin susceptibility: ring stage survival assay.
• P. falciparum drug susceptibility: radioactive hypoxanthine uptake assay.
• P. falciparum drug susceptibility: SYBR Green assay.
• P. falciparum drug susceptibility: ELISA estimation.
Other resources
• Late antimalarial treatment failure: case management of trial patients failing first-line treatment.
Diagnostic Assessment
• Malaria parasite detection microscopy manual.
Data Management
• Malaria Clinical Case Record Form: makes data easier to pool and share. Use if you're planning, collecting, managing or analysing trials/studies.
• Clinical staff data recording: best practice for recording source and case record form data for trials.
• Participant-reported antimalaria trial safety data.
• Kelch markers toolkit: enables assessment of minimal essential information needed to pool k13 marker studies.
Drug Susceptibility
• Preparation of drug plates for susceptibility assays.
• P. falciparum drug susceptibility: radioactive hypoxanthine uptake assay.
• P. falciparum drug susceptibility: SYBR Green assay.
• P. falciparum drug susceptibility: ELISA estimation.
Culturing and Synchronisation
• P. falciparum synchronisation.
• Artemisinin susceptibility: ring stage survival assay.
Sample Preparation and Preservation
• Collecting and preserving DNA, RNA and parasite isolates from infected blood samples.
• Whole blood leukocyte depletion using CF11 columns.
• Filter paper blood collection: preparing finger-prick dried blood spots for malaria molecular testing.
• Filter paper preparation for molecular genetic analysis: preparing and preserving dried blood spot samples.
• Culture medium preparation for P. falciparum cultures.
• Preparing malaria blood smears.
Sample Preparation and Genetic Analysis
• Filter paper preparation for molecular genetic analysis: preparing and preserving dried blood spot samples.
• Pharmacokinetic (PK) blood sample processing and transport.
• Pharmacokinetic (PK) urine processing and transport.
• Process for collecting, processing, and storage of genetic material.
Sample Collection and Pharmacology Analysis
• Peripheral venipuncture blood collection.
• Process for collecting and processing/extraction and storage of genetic material.
• Filter paper blood collection: preparing finger-prick dried blood spots for malaria molecular testing.
• Sample collection for pyronaridine pharmacology analysis.
• Sample collection for artemisinin pharmacology analysis.
• Sample collection for primaquine/carboxyprimaquine pharmacology analysis.
• Sample collection for amodiaquine/desethylamodiaquine pharmacology analysis.
• Sample collection for lumefantrine/desbutyl-lumefantrine pharmacology analysis.
• Sample collection for mefloquine/carboxymefloquine pharmacology analysis.
• Finger-prick/heel-stick blood collection.
• Cryopreservation of malaria parasites using glycerolyte.
Diagnostic and Exposure Assessment
• Participant-reported safety data in antimalarial trials.
• Late antimalarial treatment failure: case management of trial patients failing first-line treatment.
• Safety assessment and reporting: adverse event/drug-reaction management.
• Acute haemolysis management: by field staff during primaquine clinical trials.
• Management of hyperparasitaemia: case management of patients with hyperparasitaemia in field malaria drug trials.