Clinical Trials Publication Library Methodology

 

SEARCH TERMS AND STRATEGY

 

(malaria OR falciparum OR vivax OR ovale OR knowlesi OR malariae OR plasmodium)

AND

(act-451840 OR akafirin* OR basoquin OR camoquin OR camoquinal OR camoquine OR miaquine OR akafirine* OR propoquin OR aq-13  or arteether OR artecef OR “sm 227” OR sm227 OR artefenomel OR arteflene OR “ro 42 1611” OR “ro 42-1611” OR “ro42 1611” OR ro42-1611 OR artemether* OR artenam OR “cgp 56696” OR cgp56696 OR paluther OR artemisinin* OR artemisine* or  arterolane* OR “oz 277” OR “oz 277” OR “rbx 11160” OR rbx11160 OR artesunate* OR arinate OR armax OR arsuamoon OR arsumax OR asumax OR cosinate OR “gsunate forte” OR “ljpc 0118” OR ljpc0118 OR nuartez OR plasmotrim OR plasmotrin OR qinghaozhi OR saphnate OR “sm 804” OR sm804 OR “wr 256283” OR wr256283 OR zysunate OR atoguanil* OR atovaquone* OR 566c80 OR “bw 566c80” OR bw566c80 OR mepron OR “q 80” OR q80 OR samtirel OR wellvone OR azithromycin* OR aratro OR azacid OR azasite OR azatril OR bactrazol OR batif OR bazyt OR bezanin OR ciroz OR clamelle OR goldamycin OR infectoazit OR macromax OR makromicin OR nobaxin OR novozithron OR ordipha OR razimax OR rezan OR sumamed OR trozamil OR trozocina OR ultreon OR zaraxin or  berberine OR bulaquine OR “cdri 80 53” OR “cdri 8053” OR “cdri80 53” OR “cdri80-53” OR cdri8053 OR “compound 80 53” OR “compound 8053” OR “cdri 97/78” OR chloroquine OR a-cq OR aralen OR aralene OR avloclor OR avoclor OR bemaphate OR akafirin OR clorochina OR delagil OR gontochin OR imagon OR iroquine OR klorokin OR lagaquin OR nivachine OR nivaquin OR nivaquine OR resochin OR resoquine OR “rp 3377” OR rp3377 OR sanoquin OR “sn 7618” OR sn7618 OR tresochin OR trochin OR “w 7618” OR w7618 OR “win 244” OR win244 or  chlorpheniramine OR allergosan OR “phenamin retard” OR chlorproguanil* OR lapudrine OR “m 5943” OR m5943 OR cipargamin OR “kae 609” OR kae609 OR “nitd 609” OR nitd609 OR clindamycin OR antirobe OR aquadrops OR cleocin OR cleocine OR clinda-ipp OR clinda-saar OR clindasol OR dalacin OR sobelin OR sobeline OR “u 21251” OR “u 21251f” OR u21251 OR u21251f OR zindaclin OR cotrimoxazole OR alfatrim OR bactar OR bactipront OR akafi OR bactrimel OR bethaprim OR comoxol OR cotrim OR “drylin forte” OR duobact OR escoprim OR groprim OR kepinol OR lagatrim OR neoprim OR oecotrim OR pharmaprim OR scanprin OR sigaprim OR sulfotrim OR trimoxol OR dapsone OR aczone OR atrisone OR avlosulfon OR disulone OR “f 1358” OR f1358 OR “nsc 6091” OR nsc6091 OR servidapson* or  dihydroartemisinin* OR artekin OR duocotecxin OR eurartekin OR eurartesim OR doxycycline OR apprilon OR bactidox OR “col 101” OR col101 OR “dfd 09” OR dfd09 OR doxylin OR mespafin OR respidox OR sigadoxin OR spanor OR supracyclin OR tolexine OR vibramycin OR xyrosa OR elubaquine OR erythromycin OR “akne mycin” OR aknemycin OR “e mycin” OR e-glades OR eriprodin OR eritrex OR ferroquine OR fosmidomycin* OR “fr 31564” OR fr31564 OR “fr 31705” OR fr31705 OR ganaplacide* OR “gnf 156” OR gnf156 OR “kaf 156” OR kaf156 OR gsk701 or  halofantrine OR halfan OR “skf 102866 a” OR “wr 171669” OR imatinib OR egitinib OR gleevac OR imagerolan OR imaniver OR itivas OR leutipol OR leuzek OR meaxin OR plivatinib OR ine963 OR ketotifen OR “hc 20511” OR hc20511 OR “l9ls antibod*” OR lotilaner OR credelio OR akafirine* OR benflumetol  or  m5717* OR mmv533 OR mefloquine OR lariam OR mephaquin OR “ro 21 5998” OR metakelfin OR metakelphin OR “methylene blue*” OR “bivn 401” OR bivn401 OR “cb 17 01” OR cb1701 OR lumeblue OR “methylthioninium chloride proveblue” OR metiblo OR metilenkek OR prexablu OR provayblue OR “trx 0014” OR trx0014 or  Naphthoquine OR norfloxacin OR “am 715” OR am715 OR amicrobin OR baccidal OR barazan OR chibroxin* OR chibroxol OR esclebin OR fulgram OR gonorcin OR lexinor OR “mk 0366” OR noracin OR noroxin OR norxacin OR sebercim OR uroctal OR uroxacin OR utinor OR zoroxin OR p218 OR pafuramidine OR “db 289” OR db289 OR pentaquine OR “sn 13276” OR piperaquine OR “13228 rp” OR 13228rp OR “rp 13228” OR rp13228 or  primaquine OR “sn 13,272” OR sn13272 OR vivaquine OR “wr 2975” OR wr2975 or  probenecid OR benemid OR benemide OR benemin OR probalan OR probecid OR probenid OR procid OR prolongine OR uricosid OR urocid or  proguanil OR 336u50 OR paludrin OR paludrine or  pyrimethamine OR “bw 50 63” OR “bw 5063” OR darapraim OR darapram OR daraprim OR daraprin OR malocide OR “msc 3061” OR msc3061 OR tindurin or  pyronaridine OR quinacrine OR mepacrine OR acrichine OR acriquine OR arichin OR atabrin OR atabrine OR atatrin OR atebrin OR atebrine OR chemiochin OR chinacrin OR erion OR haffkinine OR italchine OR lamblicide OR malaricida OR methoquine OR metochin OR metoquin OR palacrin OR pentilen OR “sn 390” OR quinidine OR chinidin OR quiniday or  quinine OR chinimetten OR “gls 1200” OR gls1200 OR akafir OR “sn 359” OR surquina OR rifampicin* OR rosiglitazone OR avandia OR “brl 49653” OR brl49653* OR nyracta OR venvia OR ruxolitinib OR “inc 424” OR inc424 OR akafi OR jakavi OR “kks 278” OR kks278 OR opzelura or  sevuparin OR sj733 OR spiramycin OR captalin OR “il 5902” OR il5902 OR rovamycin OR rovamycine OR spirovet OR sulfadoxine* OR fanasil OR sulfamethoxazole OR sinomin OR sulfamonomethoxine OR “dj 1550” OR dj1550 OR “ds 36” OR ds36 OR “ici 32525” OR ici32525 OR sulfamethoxypyrazine OR sulfalene or  tafenoquine OR arakoda OR etaquine OR kodatef OR kozenis OR krintafel OR “sb 252263*” OR sb252263*  or  tetracycline OR achromycin OR acromycin OR actisite OR “ala tet” OR alatet OR “apo tetra” OR apocyclin OR beatacycline OR bicycline OR brodspec OR cadicycline OR dhatracin OR economycin OR enkacyclin OR florocycline OR hostaciclina OR medocycline OR mysteclin OR novotetra OR panmycin OR pantocycline OR quimocyclar OR sarocycline OR teracyn OR topicycline or  trimethoprim OR “bw 56 72” OR “bw 5672” OR delprim OR primosept OR proloprim OR trimopan OR trimpex OR triprim OR welcoprim  or  “xtb-31f mab” OR zy-19489*))

2022-2023

 

Databases

International databases:

MEDLINE

Embase

Global Health

Scopus

Web of Science

Cochrane Database of Systematic Reviews

Regional:

LILACS

Global Index Medicus (AIM (AFRO), IMEMR (EMRO), IMSEAR (SEARO), LILACS (AMRO/OPAS)

Grey Literature

OpenGrey

Trial registries:

ClinicalTrials.gov

WHO ICTRP

 

After de-duplication, filtering for relevant studies is completed using the following criteria;

 

WCTL Inclusion and Exclusion Criteria

WCTL Inclusion Criteria:

WCTL Exclusion Criteria: 

  • Human-infecting Plasmodium species (including mixed infections)
  • Study inclusive of uncomplicated malaria only treatment arms or uncomplicated and severe treatment arms
  • Prospective studies, including studies with patients with post-treatment infections
  • Assessing efficacy of any antimalarial drug
  • Follow-up of at least 7 days
  • Any language

 

  • Animal studies
  • Prevention or prophylaxis studies
  • Intermittent preventive treatment studies
  • Intermittent screening and treatment studies in pregnancy
  • Mass drug administration
  • Studies including only severe malaria
  • Herbal medicine*
  • Asymptomatic/induced malaria studies
  • Case reports, Case series
  • Reviews, opinion pieces and meta-analyses
  • Retrospective studies
  • Conference abstracts
  • Healthy volunteers
  • Experimental/In-vitro studies