Study Groups

WWARN facilitates a number of collaborative Study Groups to undertake individual patient data meta-analyses to answer specific research questions about malaria treatments and antimalarial drug resistance. Gathering and combining data sets from multiple studies increases sample sizes, so that effects, including smaller effects, and effects on sub-populations can be identified with greater certainty. Working together and combining data from different regions and populations is improving our understanding of drug resistance and strengthening global efforts to control and eventually eliminate malaria.

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Dominic Chavez World Bank

Subpatent Malaria and Pregnancy Outcome Study Group

The Subpatent Malaria and Pregnancy Outcome Study Group aims to explore the relationship between subpatent Plasmodium falciparum malaria inf...

The Subpatent Malaria and Pregnancy Outcome Study Group aims to explore the relationship between subpatent Plasmodium falciparum malaria infection and pregnancy outcome

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Molecular Markers of Resistance in West Africa Study Group

This Study Group aims to bring together and explore the latest evidence on the prevalence of molecular markers associated with antimalarial drug resis...

This Study Group aims to bring together and explore the latest evidence on the prevalence of molecular markers associated with antimalarial drug resistance in West African Countries.

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SP Resistance Data Access Group

The sulphadoxine-pyrimethamine (SP) resistance Data Access Group’s aim is to provide maps and open access to the most recent data on molecular markers...

The sulphadoxine-pyrimethamine (SP) resistance Data Access Group’s aim is to provide maps and open access to the most recent data on molecular markers of SP resistance to help policy makers make informed decisions with regard to use of SP for intermittent preventive treatment of malaria in pregnancy (IPTp) or seasonal malaria chemoprevention (SMC).

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Vivax and Ovale Paediatric Primaquine Haematological Safety Study Group

Analysis of how age impacts the effect of primaquine dose on haematological safety in patients with Plasmodium vivax and Plasmodium ovale malaria

Intermittent preventive treatment in pregnancy (IPTp) and SP-resistance-associated mutations Study Group

The overall aim of the IPTp and SP-resistance-associated mutations Study Group is to quantify how parasites with the sextuple mutant pfdhps and pfdhfr...

The overall aim of the IPTp and SP-resistance-associated mutations Study Group is to quantify how parasites with the sextuple mutant pfdhps and pfdhfr haplotype* modify the effect of IPTp on maternal and infant outcomes.

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Low-dose Primaquine Efficacy and Safety Study Groups

Pooled analyses of the efficacy and safety of single low-dose primaquine to interrupt P. falciparum malaria transmission.Data collection has closed an...

Pooled analyses of the efficacy and safety of single low-dose primaquine to interrupt P. falciparum malaria transmission.

Data collection has closed and curation is ongoing. Analysis and draft publications are planned for circulation to the Group by the June of 2017.

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Antimalarial–Antiretroviral Analyses

Sub-study groups include the Artemether-Lumefantrine / ARV PK Study Group and the ACT-ARV Safety Study Group.

ACT Asia Baseline Study Group

Baseline information on parasitological response to ACTs in AsiaA pooled analysis to assess the baseline early parasitological response after artemisi...

Baseline information on parasitological response to ACTs in Asia

A pooled analysis to assess the baseline early parasitological response after artemisinin combination therapy (ACT) treatment in Asia. The analysis compiles the day 3 parasite positivity rates (PPR) in patients with uncomplicated Plasmodium falciparum malaria enrolled in ACT clinical efficacy trials conducted in Asia.

Data gathering and curation has started. Data meeting the inclusion criteria has already been collected and standardised from over 12,000 patients. Data analysis will start April 2015 with a manuscript schedules for submission and publication by December 2015. 

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Vivax After Falciparum Study Group

This Study Group will explore the link between P. vivax recurrence and prior P. falciparum treatment, including increased risk of vivax para...

This Study Group will explore the link between P. vivax recurrence and prior P. falciparum treatment, including increased risk of vivax parasitaemia due to acute malaria infection.

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Vivax Adherence Study Group

Piperaquine Pharmacokinetics in Pregnancy Study Group

Determining the effects of pregnancy on piperaquine pharmacokinetics. The analysis aims to contribute evidence needed to inform recommendations on the...

Determining the effects of pregnancy on piperaquine pharmacokinetics. The analysis aims to contribute evidence needed to inform recommendations on the use and optimal dosing of piperaquine in pregnant women.

Determining the effects of pregnancy on piperaquine pharmacokinetics. The analysis aims to contribute evidence needed to inform recommendations on the use and optimal dosing of piperaquine in pregnant women.

 

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AS-AQ Post-Treatment Prophylaxis Study Group

Modelling the protective effect of Artesunate-Amodiaquine (AS-AQ)A pooled analysis to assess the post-treatment prophylactic effect of artesunate-amod...

Modelling the protective effect of Artesunate-Amodiaquine (AS-AQ)

A pooled analysis to assess the post-treatment prophylactic effect of artesunate-amodiaquine (AS-AQ). The group is quantifying the duration of post-treatment prophylaxis mediated by AS-AQ and how it depends on host factors such as .

The Study Group closed in January 2014. The AS-AQ Post-Treatment Prophylaxis Study Group manuscript is under review at BMC Medicine. 

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Ivermectin Pharmacokinetics in Children and Adults Study Group

Characterising the population pharmacokinetic properties of ivermectin in children and adults to inform optimal dosing of ivermectin
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Malaria in Pregnancy Infant Study Group

Exploring the impact of malaria during pregnancy on infant anaemia, malaria, morbidity and growth – an individual participant meta-analysis. 
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Piperaquine (Cardiac) Safety Study Group

The Piperaquine Safety Study Group’s aim is to establish the evidence-base and safety profile to inform decision-making on the use and optimal dosing ...

The Piperaquine Safety Study Group’s aim is to establish the evidence-base and safety profile to inform decision-making on the use and optimal dosing of dihydroartemisinin-piperaquine in all key target populations.

The study group call for contributors opened in June 2016 with a first scoping meeting held in July. Data collection is planned to close by end of 2016, with analysis due in 2018-2019.

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Lumefantrine – ARV PK/PD Study Group

An analysis of pooled individual patient data to determine the effect of antiretroviral (ARV) drug-drug interactions and HIV disease on lumefantr...

An analysis of pooled individual patient data to determine the effect of antiretroviral (ARV) drug-drug interactions and HIV disease on lumefantrine pharmacokinetics (and pharmacodynamics).

This study group has just opened for data collection. If you have any data you would like to share, or if you would like to participate in the project, please contact pharmacology@wwarn.org.

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lymphocyte with rbcs

White Blood Cell Count in Malaria Study Group

Determining what affects White Blood Cell (WBC) count at baseline and during acute phase of malaria infection.  

PCE Data Interpretation Study Group

Development of statistical methods to infer the relationship between the percentage of resistant infections, parasite clearance half-life and the prop...

Development of statistical methods to infer the relationship between the percentage of resistant infections, parasite clearance half-life and the proportion of treated individuals still positive on days one, two and three of treatment

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mothers and babies in health centre. Sierra Leone

Sub-study Impact of first-trimester malaria in pregnancy on the mother and infant

This study group aims to determine the impact of malaria in the first trimester of pregnancy on the mother and infant through individual patient data ...

This study group aims to determine the impact of malaria in the first trimester of pregnancy on the mother and infant through individual patient data meta-analysis (IPDMA).

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Paediatric single low-dose primaquine safety study group

The paediatric single low-dose (SLD) primaquine safety study group aims to describe and compare the safety of SLD primaquine for transmission blocking...

The paediatric single low-dose (SLD) primaquine safety study group aims to describe and compare the safety of SLD primaquine for transmission blocking of Plasmodium falciparum in young children (under 5 years of age) with that in older children and adults.

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