Study Groups
WWARN facilitates a number of collaborative Study Groups to undertake individual patient data meta-analyses to answer specific research questions about malaria treatments and antimalarial drug resistance. Gathering and combining data sets from multiple studies increases sample sizes, so that effects, including smaller effects, and effects on sub-populations can be identified with greater certainty. Working together and combining data from different regions and populations is improving our understanding of drug resistance and strengthening global efforts to control and eventually eliminate malaria.
Pooled analyses of the efficacy and safety of single low-dose primaquine to interrupt P. falciparum malaria transmission.Data collection has closed an...
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This is an extension of a planned dihydroartemisinin-piperaquine (DP) Safety Study Group, which aims to consider the effect of HIV disease and co-admi...
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Development of statistical methods to infer the relationship between the percentage of resistant infections, parasite clearance half-life and the prop...
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Analysis of the effect of primaquine dose on tolerability and Plasmodium vivax recurrence.
Analysis of how age impacts the effect of primaquine dose on haematological safety in patients with Plasmodium vivax and Plasmodium ovale malaria
This study group aims to determine the impact of malaria in the first trimester of pregnancy on the mother and infant through individual patient data ...
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Characterising the population pharmacokinetic properties of ivermectin in children and adults to inform optimal dosing of ivermectin
Modelling the protective effect of Artesunate-Amodiaquine (AS-AQ)A pooled analysis to assess the post-treatment prophylactic effect of artesunate-amod...
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Assessing the efficacy of a range of antimalarials used for the treatment of P. falciparum malaria in all trimesters of pregnancy in Africa ...
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A pooled analysis assessing the effect of mg/kg dosing strategies on the risk of treatment failure in patients treated with the currently recommended ...
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The paediatric single low-dose (SLD) primaquine efficacy study group aims to assess and compare the efficacy of SLD primaquine for transmission blocki...
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Analysis of how age impacts the effect of primaquine dose on efficacy in patients with Plasmodium vivax and Plasmodium ovale malaria
This is an extension of the WWARN Haemoglobin-Haematocrit Relationship in Malaria Study Group and the Antimalarial–Antiretroviral Analy...
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The First Trimester Safety of ACTs Study Group’s aim is to establish the evidence-base and safety profile to inform decision-making on the use of arte...
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Baseline information on parasitological response to ACTs in AsiaA pooled analysis to assess the baseline early parasitological response after artemisi...
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This Study Group aims to bring together and explore the latest evidence on the prevalence of molecular markers associated with antimalarial drug resis...
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A pooled analysis of methaemoglobin as a marker of primaquine antihypnozoite activity in Plasmodium vivax malaria
The Dihydroartemisinin-Piperaquine for Intermittent Preventive Treatment in Pregnancy Study Group aims to determine the safety and efficacy of intermi...
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The Plasmodium vivax fever study group aims to estimate parasitaemia thresholds for febrile patients who present for treatment and determine the ...
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