Category
Dr
Prabin
Dahal
Head of Statistics
Email
Research Theme
Visceral leishmaniasis
Malaria
Chagas
Trachoma
WWARN
Prabin joined the WorldWide Antimalarial Research Network (WWARN) – the prototypic model to IDDO – as a statistician in September 2011. His work with WWARN included assessment of the relationship between weight-adjusted dose and parasitological outcomes for artemisinin combination therapies.
His doctoral thesis (2015–2018, Linacre College) explored different statistical approaches for handling parasitic recurrences when quantifying antimalarial blood stage efficacy in P. falciparum.
In his current role, Prabin's main focus is the quantification of risk of severe and serious adverse events following antileishmanial therapies. His interest lies in exploring methodological issues in design and analysis of antileishmanial clinical trials.
Research Theme: VL, Malaria, Non-Malarial Febrile Illness
All Publications
Baseline results of a living systematic review for COVID-19 clinical trial registrations
Maguire, B., McLean, A., Rashan, S., Antonio, E., Bagaria, J., Bentounsi, Z., Brack, M., Caldwell, F., Carrara, V., Citarella, B., Dahal, P., Feteh, V., Guérin, M., Kennon, K., Bilton Lahaut, K., Makuka, G., Ngu, R., Obiesie, S., Richmond, C., … Guérin, P. (2020). Wellcome Open Research, 5.
The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data
Bretscher, M., Dahal, P., Griffin, J., Stepniewska, K., Bassat, Q., Baudin, E., D’Alessandro, U., Djimde, A., Dorsey, G., Espié, E., Fofana, B., González, R., Juma, E., Karema, C., Lasry, E., Lell, B., Lima, N., Menéndez, C., Mombo-Ngoma, G., … Okell, L. (2020). BMC Medicine, 18(1).
Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting
Dahal, P., Stepniewska, K., Guerin, P., D’Alessandro, U., Price, R., & Simpson, J. (2019). BMC Medical Research Methodology, 19.
Scrub typhus ecology: a systematic review of Orientia in vectors and hosts
Elliott, I., Pearson, I., Dahal, P., Thomas, N., Roberts, T., & Newton, P. (2019). Parasites and Vectors, 12(1).
The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: a systematic review and individual patient data meta-analysis
Commons, R., Simpson, J., Thriemer, K., Abreha, T., Adam, I., Anstey, N., Assefa, A., Awab, G., Baird, J., Barber, B., Chu, C., Dahal, P., Daher, A., Davis, T., Dondorp, A., Grigg, M., Humphreys, G., Hwang, J., Karunajeewa, H., … Price, R. (2019). PLOS Medicine, 16(10).
Modifiable predictors of severe heart failure in Morocco: a descriptive study using routinely collected health data
Kone, A., Cherif, M., Prabin, D., Dumre, S., Doumbouya, A., Kapche, D., Camara, F., Saousan, S., Sara, K., Diakite, M., Cisse, M., Azzouzi, L., & Habbal, R. (2019). Pan African Medical Journal, 34(6).
The haematological consequences of plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Commons, R., Simpson, J., Thriemer, K., Chu, C., Douglas, N., Abreha, T., Alemu, S., Añez, A., Anstey, N., Aseffa, A., Assefa, A., Awab, G., Baird, K., Barber, B., Borghini-Fuhrer, I., D’Alessandro, U., Dahal, P., Daher, A., De Vries, P., … Guerin, P. (2019). BMC Medicine, 17.
A pooled analysis of the duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine
Bretscher, M., Dahal, P., Griffin, J., Stepniewska, K., Bassat, Q., Baudin, E., D’Alessandro, U., Djimde, A., Dorsey, G., Espie, E., Fofana, B., Gonzalez, R., Juma, E., Karema, C., Lasry, E., Lell, B., Lima, N., Menendez, C., Mombo-Ngoma, G., … Okell, L. (2019).
The effect of dose on the antimalarial efficacy of artesunate-mefloquine against Plasmodium falciparum malaria: a protocol for systematic review and individual patient data (IPD) meta-analysis
Mansoor, R., Dahal, P., Humphreys, G., Guerin, P., Ashley, E., & Stepniewska, K. (2019). BMJ Open, 9(6).
Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study
Dahal, P., Guerin, P., Price, R., Simpson, J., & Stepniewska, K. (2019). BMC Medical Research Methodology, 19.
Morbidity and mortality outcomes in neonates who were transferred from home and hospitals to the only neonatal intensive care unit in Guinea: a descriptive report using routinely collected health data
Cherif, M., Dahal, P., Mansoor, R., Camara, F., Bah, A., Kone, A., Cherif, F., Kasse, D., Diakite, M., & Diallo, M. (2019). International Health, 11(6), 455-462.
ESTIMATION OF INCIDENCE RISK OF MORTALITY AND SERIOUS ADVERSE EVENTS FOR ANTILEISHMANIAL THERAPIES: AN INFECTIOUS DISEASES DATA OBSERVATORY SYSTEMATIC REVIEW OF PUBLISHED LITERATURE FROM 1980 TO 2018
Singh, S., Dahal, P., Ngu, R., Maguire, B., Olliaro, P., Stepniewska, K., & Guerin, P. (2019). TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 113, S69 - S69.
ESTIMATION OF INCIDENCE RATE OF MORTALITY FOR ANTILEISHMANIAL THERAPIES: A SYSTEMATIC REVIEW OF PUBLISHED LITERATURE FROM 1980 TO 2018
Singh, S., Dahal, P., Ngu, R., Maguire, B., Olliaro, P., Stepniewska, K., Halleux, C., & Alves, F. (2019). AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 101, 400-401.
Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine (vol 91, pg 833, 2014)
Venkatesan, M., Gadalla, N., Stepniewska, K., Dahal, P., Nsanzabana, C., Moriera, C., Price, R., Martensson, A., Rosenthal, P., Dorsey, G., Sutherland, C., Guerin, P., Davis, T., Menard, D., Adam, I., Ademowo, G., Arze, C., Baliraine, F., Berens-Riha, N., … Ogutu, B. (2019). AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 3.
Simulation studies to quantify the impact of competing risk events in a hypothetical scenario of falling antimalarial drug efficacy in single-armed and comparative drug trials
Dahal, P., Guerin, P., Price, R., Simpson, J., & Stepniewska, K. (2018). American Journal of Tropical Medicine and Hygiene, 99(4), 442-443.
Dealing with indeterminate outcomes in antimalarial efficacy trials: A comparison between complete case analysis, multiple imputation and inverse probability weighting
Dahal, P., Stepniewska, K., Guerin, P., D’Alessandro, U., Price, R., & Simpson, J. (2018). American Journal of Tropical Medicine and Hygiene, 99(S4), 546.
The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis
Commons, R., Simpson, J., Thriemer, K., Humphreys, G., Abreha, T., Alemu, S., Añez, A., Anstey, N., Awab, G., Baird, J., Barber, B., Borghini-Fuhrer, I., Chu, C., D’Alessandro, U., Dahal, P., Daher, A., De Vries, P., Erhart, A., Gomes, M., … Woodrow, C. (2018). Lancet Infectious Diseases, 18(9), 1025-1034.
Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges
Dahal, P., Simpson, J., Dorsey, G., Guérin, P., Price, R., & Stepniewska, K. (2017). Malaria Journal, 16(1), 430.
The consequences of censoring new infections when deriving antimalarial efficacy against uncomplicated P. falciparum malaria
Dahal, P. (2017). Tropical Medicine and International Health, 22(S1), 33.
On the adequacy of a 28 day follow-up period for artemether limefantrine against uncomplicated plasmodium falciparum malaria
Dahal, P. (2017). American Journal of Tropical Medicine and Hygeine, 95(S5), 267-268.
Population pharmacokinetic properties of Piperaquine in Falciparum Malaria: an individual participant data-level meta-analysis
Hoglund, R., Workman, L., Edstein, M., Thanh, N., Quang, N., Zongo, I., Ouedraogo, J., Borrmann, S., Mwai, L., Nsanzabana, C., Price, R., Dahal, P., Nosten, F., Ashley, E., Phyo, A., Lwin, K., McGready, R., Day, N., Guerin, P., … Tarning, J. (2017). PLoS Medicine.
THE CONSEQUENCES OF CENSORING NEW INFECTIONS WHEN DERIVING ANTIMALARIAL EFFICACY AGAINST UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA
Dahal, P., & Grp, W. (2017). AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 5.
Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: A systematic review and meta-analysis of individual patient data
Abdulla, S., Achan, J., Yeka, A., D’Alessandro, U., Adam, I., Alemayehu, B., Allan, R., Temu, E., Allen, E., Barnes, K., Anvikar, A., Valecha, N., Arinaitwe, E., Ashley, E., Carrara, V., McGready, R., Nosten, F., Lee, S., White, N., … Kapulu, M. (2016). BMC Medicine, 14(1).
Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: A systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data
Ashley, E., Aweeka, F., Barnes, K., Bassat, Q., Borrmann, S., Dahal, P., Davis, T., Deloron, P., Denis, M., Djimde, A., Faucher, J., Genton, B., Guérin, P., Hamed, K., Hodel, E., Huang, L., Jullien, V., Karunajeewa, H., Kiechel, … Workman, L. (2015). BMC Medicine, 13(1).
Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis
Abdulla, S., Ashley, E., Bassat, Q., Bethell, D., Bjorkman, A., Borrmann, S., D’Alessandro, U., Dahal, P., Day, N., Diakite, M., Djimde, A., Dondorp, A., Duong, S., Edstein, Fairhurst, R., Faiz, M., Falade, C., Flegg, J., Fogg, C., … Winstanley, P. (2015). Malaria Journal, 14(1).