Category
Professor
Paul
Newton
Head of Medicine Quality Research Group
Email
Research Theme
Medicine quality
Professor Paul Newton is Head of the IDDO Medicine Quality Research Group. He was appointed Head of the WorldWide Antimalarial Research Network (WWARN) Antimalarial Quality Group in 2010. He was the founding Director of the Lao-Oxford-Mahosot-Wellcome Trust Research Unit (LOMWRU) in the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, from 2000 to 2019 and now works based from Oxford. After junior doctor training in infectious disease and internal medicine in the UK, he worked in the Mahidol Oxford Research Unit in Bangkok on malaria and melioidosis for four years before moving to Laos.
Key Publications
Non-malarial febrile illness: a systematic review of published aetiological studies and case reports from Southern Asia and South-eastern Asia, 1980-2015
Shrestha, P., Dahal, P., Ogbonnaa-Njoku, C., Das, D., Stepniewska, K., Thomas, N., Hopkins, H., Crump, J., Bell, D., Newton, P., Ashley, E., & Guérin, P. (2020). BMC Medicine, 18.
Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia
Grist, E., Flegg, J., Humphreys, G., Mas, I., Ashley, E., Humphreys, G., Dhorda, M., Dondorp, A., Hien, T., Maude, R., Mayxay, M., Nosten, F., Newton, P., Price, R., Smithuis, F., White, N., Woodrow, C., Guerin, P., & Gething, P. (2016). International Journal of Health Geographics, 15(37), 1-10.
Quality assurance of drugs used in clinical trials: proposal for adapting guidelines
Newton, P., Schellenberg, D., Ashley, E., Ravinetto, R., Green, M., ter Kuile, F., Tabernero, P., White, N., & Guerin, P. (2015). BMJ, 350.
Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis
Abdulla, S., Ashley, E., Bassat, Q., Bethell, D., Bjorkman, A., Borrmann, S., D’Alessandro, U., Dahal, P., Day, N., Diakite, M., Djimde, A., Dondorp, A., Duong, S., Edstein, Fairhurst, R., Faiz, M., Falade, C., Flegg, J., Fogg, C., … Winstanley, P. (2015). Malaria Journal, 14(1).
Falsified medicines in Africa: all talk, no action
Newton, P., Tabernero, P., Dwivedi, P., Culzoni, M., Monge, M., Swamidoss, I., Mildenhall, D., Green, M., Jähnke, R., de Oliveira, M., Simao, J., White, N., & Fernández, F. (2014). Lancet Global Health, 2(9), e509 - e510.
Spread of artemisinin resistance in Plasmodium falciparum malaria.
Ashley, E., Dhorda, M., Fairhurst, R., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J., Mao, S., Sam, B., Sopha, C., Chuor, C., Nguon, C., Sovannaroth, S., Pukrittayakamee, S., Jittamala, P., Chotivanich, K., Chutasmit, K., Suchatsoonthorn, C., … Tracking Resistance to Artemisinin Collaboration (TRAC). (2014). The New England Journal of Medicine, 371(5), 411-423.
Spread of artemisinin resistance in Plasmodium falciparum malaria.
Ashley, E., Dhorda, M., Fairhurst, R., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J., Mao, S., Sam, B., Sopha, C., Chuor, C., Nguon, C., Sovannaroth, S., Pukrittayakamee, S., Jittamala, P., Chotivanich, K., Chutasmit, K., Suchatsoonthorn, C., … Tracking Resistance to Artemisinin Collaboration (TRAC). (2014). The New England Journal of Medicine, 371(5), 411-423.
Mind the gaps--the epidemiology of poor-quality anti-malarials in the malarious world--analysis of the WorldWide Antimalarial Resistance Network database.
Tabernero, P., Fernández, F., Green, M., Guerin, P., & Newton, P. (2014). Malaria Journal, 13, 139.
The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
Achan, J., Adam, I., Arinaitwe, E., Ashley, E., Awab, G., Barnes, K., Bassat, Q., Borrmann, S., Bousema, T., Dahal, P., D’Alessandro, U., Davis, T., Dondorp, A., Dorsey, G., Drakeley, C., Fanello, C., Faye, B., Flegg, J., Gaye, O., … Phyo, A. (2013). PLOS MEDICINE, 10(12), 1-17.
The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
Achan, J., Adam, I., Arinaitwe, E., Ashley, E., Awab, G., Barnes, K., Bassat, Q., Borrmann, S., Bousema, T., Dahal, P., D’Alessandro, U., Davis, T., Dondorp, A., Dorsey, G., Drakeley, C., Fanello, C., Faye, B., Flegg, J., Gaye, O., … Phyo, A. (2013). PLOS MEDICINE, 10(12), 1-17.
Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives
Flegg, J., Guérin, P., Nosten, F., Ashley, E., Phyo, A., Dondorp, A., Fairhurst, R., Socheat, D., Borrmann, S., Björkman, A., Mårtensson, A., Mayxay, M., Newton, P., Bethell, D., Se, Y., Noedl, H., Diakite, M., Djimde, A., Hien, T., … Stepniewska, K. (2013). Malaria Journal, 12.
Causes of non-malarial fever in Laos: a prospective study
Mayxay, M., Castonguay-Vanier, J., Chansamouth, V., Dubot-Pérès, A., Paris, D., Phetsouvanh, R., Tangkhabuanbutra, J., Douangdala, P., Inthalath, S., Souvannasing, P., Slesak, G., Tongyoo, N., Chanthongthip, A., Panyanouvong, P., Sibounheuang, B., Phommasone, K., Dohnt, M., Phonekeo, D., Hongvanthong, B., … Newton, P. (2013). Lancet Global Health, 1(1), e46 - e54.
Evaluation of a simple blood culture amplification and antigen detection method for diagnosis of Salmonella enterica serovar typhi bacteremia.
Castonguay-Vanier, J., Davong, V., Bouthasavong, L., Sengdetka, D., Simmalavong, M., Seupsavith, A., Dance, D., Baker, S., Le Thi Phuong, T., Vongsouvath, M., & Newton, P. (2013). J Clin Microbiol, 51(1), 142-148.
A collaborative epidemiological investigation into the criminal fake artesunate trade in South East Asia.
Newton, P., Fernández, F., Plançon, A., Mildenhall, D., Ziyong, L., Christophel, E., Phanouvong, S., Howells, S., McIntosh, E., Laurin, P., Blum, N., Hampton, C., Faure, K., Nyadong, L., Soong, C., Santoso, B., Zhiguang, W., Newton, J., & Palmer, K. (2008). PLoS Medicine, 5(2), e32.
Causes of community-acquired bacteremia and patterns of antimicrobial resistance in Vientiane, Laos.
Phetsouvanh, R., Phongmany, S., Soukaloun, D., Rasachak, B., Soukhaseum, V., Soukhaseum, S., Frichithavong, K., Khounnorath, S., Pengdee, B., Phiasakha, K., Chu, V., Luangxay, K., Rattanavong, S., Sisouk, K., Keolouangkot, V., Mayxay, M., Ramsay, A., Blacksell, S., Campbell, J., … Newton, P. (2006). Am J Trop Med Hyg, 75(5), 978-985.
Counterfeit anti-infective drugs.
Newton, P., Green, M., Fernández, F., Day, N., & White, N. (2006). Lancet Infect Dis, 6(9), 602-613.
Manslaughter by fake artesunate in Asia - will Africa be next?
Newton, P., McGready, R., Fernandez, F., Green, Sunjio, M., Bruneton, C., Phanouvong, S., Millet, P., Whitty, C., Talisuna, A., Proux, S., Christophel, E., Malenga, G., Singhasivanon, P., Bojang, K., Kaur, H., Palmer, K., Day, N., Greenwood, B., … White, N. (2006). PLoS Medicine, 3(6), e197.
Rickettsial infections and fever, Vientiane, Laos.
Phongmany, S., Rolain, J.-M., Phetsouvanh, R., Blacksell, S., Soukkhaseum, V., Rasachack, B., Phiasakha, K., Soukkhaseum, S., Frichithavong, K., Chu, V., Keolouangkhot, V., Martinez-Aussel, B., Chang, K., Darasavath, C., Rattanavong, O., Sisouphone, S., Mayxay, M., Vidamaly, S., Parola, P., … Newton, P. (2006). Emerging Infectious Diseases, 12(2), 256-262.
Randomized comparison of artesunate and quinine in the treatment of severe falciparum malaria.
Newton, P., Angus BJ, Chierakul W, & Dondorp A. (2003). Clinical Infectious Diseases, 37(1), 7-16.
Fake artesunate in southeast Asia.
Newton, P., Green M, Proux S, & Smithuis F. (2001). The Lancet, 357(9272), 1948-1950.
All Publications
IgG Antibodies to Pneumococcal Serotypes 1 and 5 in Relation to PCV13 Vaccination Status in Children Aged Under 5 Years in Lao PDR: A Cross-Sectional Survey
Toh, Z., Tang, K., Vilivong, K., Lai, J., Bounkhoun, T., Chanthaluanglath, V., Chanthongthip, A., Balloch, A., Newton, P., Dubot-Pérès, A., Dance, D., Licciardi, P., & Russell, F. (2025). Vaccines, 13(8), 873.
Estimating scrub typhus and murine typhus incidence among adolescents and adults in Yangon, Myanmar
Oo, W., Bowhay, T., Myat, T., Htike, W., Lwin, K., Blacksell, S., Tanganuchitcharnchai, A., Mayxay, M., Newton, P., Robinson, M., Ussher, J., Murdoch, D., Win, H., & Crump, J. (2025). Tropical Medicine and International Health.
Prevalence and risk factors for murine typhus, scrub typhus, and spotted fever group rickettsioses among adolescent and adult patients presenting to Yangon General Hospital, Yangon, Myanmar
Bowhay, T., Myat, T., Oo, W., Mone, H., Sharples, K., Robinson, M., Mayxay, M., Newton, P., Blacksell, S., Tanganuchitcharnchai, A., Ussher, J., Murdoch, D., Htike, W., & Crump, J. (2025). Tropical Medicine and International Health.
Handheld spatially offset raman spectroscopy for rapid non-invasive detection of ethylene glycol and diethylene glycol in medicinal syrups
Banerjee, S., Mosca, S., Legge, I., Gangadharan, B., Walsby-tickle, J., Arman, B., Stokes, R., Bharucha, T., Deats, M., Merchant, H., McCullagh, J., Zitzmann, N., Caillet, C., Newton, P., & Matousek, P. (2025). Journal of Pharmaceutical and Biomedical Analysis, 265.
Pneumococcal density and respiratory co-detection in severe pediatric pneumonia in Laos
Dubot-Pérès, A., Lee, S., Dance, D., Satzke, C., Moore, K., Pell, C., Ortika, B., Nation, M., Dunne, E., Vilivong, K., Bounkhoun, T., Phommachan, S., Lim, R., Lai, J., Morpeth, M., Mayxay, M., de Lamballerie, X., Newton, P., & Russell, F. (2025). Scientific Reports, 15(1).
Genetic surveillance of Plasmodium falciparum populations following treatment policy revisions in the Greater Mekong Subregion
Wasakul, V., Verschuuren, T., Thuy-Nhien, N., Booth, E., Quang, H., Thang, N., Chindavongsa, K., Sovannaroth, S., Banouvong, V., Sengsavath, V., Mayxay, M., Tuyen, N., Phuong, V., Duc Trung, P., Gonçalves, S., Chen, S., Phalivong, S., Xayvanghang, S., Mahaphontrakoon, S., … Miotto, O. (2025). Nature Communications, 16(1).
Detection of Mycoplasma pneumoniae in hospitalized children with pneumonia in Laos
Vilivong, K., Mayxay, M., Dance, D., De Lamballerie, X., Newton, P., & Dubot-Pérès, A. (2025). Wellcome Open Research, 8, 533.
Hide and seek with falsified medicines: Current challenges and physico-chemical and biological approaches for tracing the origin of trafficked products.
Perez-Mon, C., Hauk, C., Roncone, A., Bontempo, L., Kelly, S., Caillet, C., Deats, M., Ogden, R., & Newton, P. (2025). Forensic Science International, 370, 112474.
Detection of Mycoplasma pneumoniae in hospitalized children with pneumonia in Laos
Vilivong, K., Mayxay, M., Dance, D., De Lamballerie, X., Newton, P., & Dubot-Pérès, A. (2025). Wellcome Open Research, 8, 533.
Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry
Arman, B., Clarke, R., Bharucha, T., Fernandez, L., Walsby-Tickle, J., Deats, M., Mosca, S., Lin, Q., Banerjee, S., Chunekar, S., Patil, K., Gairola, S., Dunachie, S., Merchant, H., Stokes, R., Kuwana, R., Maes, A., Charrier, J.-P., Probert, F., … Gangadharan, B. (2025). Npj Vaccines, 10(1).
A systematic review of the noma evidence landscape: current knowledge and gaps
Maguire, B., Shrestha, R., Dahal, P., Ngu, R., Nizigama, L., Rashan, S., Shrestha, P., Harriss, E., Newton, P., Makino, Y., Varenne, B., & Guérin, P. (2025). In medRxiv.
Understanding hospital antimicrobial prescribing decisions and determinants of uptake of new local antimicrobial prescribing guidelines in Laos
Chansamouth, V., Douangnouvong, A., Thammavongsa, P., Sombandith, X., Keomany, S., Rattana, S., Newton, P., Day, N., Turner, P., Mayxay, M., van Doorn, H., & Ashley, E. (2024). Wellcome Open Research, 9, 183.
Using matrix assisted laser desorption ionisation mass spectrometry combined with machine learning for vaccine authenticity screening
Clarke, R., Bharucha, T., Arman, Y., Gangadharan, B., Gomez Fernandez, L., Mosca, S., Lin, Q., Van Assche, K., Stokes, R., Dunachie, S., Deats, M., Merchant, H., Caillet, C., Walsby-tickle, J., Probert, F., Matousek, P., Newton, P., Zitzmann, N., & McCullagh, J. (2024). Npj Vaccines, 9(1).
Non-malarial febrile illness: a systematic review of published aetiological studies and case reports from China, 1980–2015
Ip, D., Ng, Y., Tam, Y., Thomas, N., Dahal, P., Stepniewska, K., Newton, P., Guérin, P., & Hopkins, H. (2024). BMC Infectious Diseases, 24(1).
Detection of Mycoplasma pneumoniae in hospitalized children with pneumonia in Laos
Vilivong, K., Mayxay, M., Dance, D., De Lamballerie, X., Newton, P., & Dubot-Pérès, A. (2024). Wellcome Open Research, 8.
Stable isotope ratio analysis: an emerging tool to trace the origin of falsified medicines
Roncone, A., Kelly, S., Giannioti, Z., Hauk, C., Caillet, C., Newton, P., Perez-Mon, C., & Bontempo, L. (2024). Trends in Analytical Chemistry, 174.
Understanding hospital antimicrobial prescribing decisions and determinants of uptake of new local antimicrobial prescribing guidelines in the Laos
Chansamouth, V., Day, N., Douangnouvong, A., Thammavongsa, P., Sombandith, X., Keomany, S., Rattana, S., Newton, P., Turner, P., Mayxay, M., van Doorn, R., & Ashley, E. (2024). Wellcome Open Research, 9.
Forensic investigation of falsified antimalarials using isotope ratio mass spectrometry: a pilot investigation
Newton, P., Chesson, L., Mayxay, M., Dondorp, A., Tabernero, P., Howa, J., & Cerling, T. (2024). Scientific Reports, 14(1).
Repurposing rapid diagnostic tests to detect falsified vaccines in supply chains
Bharucha, T., Gangadharan, B., Clarke, R., Gomez Fernandez, L., Yohan Arman, B., Walsby-tickle, J., Deats, M., Mosca, S., Lin, Q., Stokes, R., Dunachie, S., Merchant, H., Dubot-Peres, A., Caillet, C., McCullagh, J., Matousek, P., Zitzmann, N., & Newton, P. (2024). Vaccine.
Estimating the subnational prevalence of antimicrobial resistant Salmonella enterica serovars Typhi and Paratyphi A infections in 75 endemic countries, 1990–2019: a modelling study
Browne, A., Chipeta, M., Fell, F., Haines-Woodhouse, G., Kashef Hamadani, B., Kumaran, E., Robles Aguilar, G., McManigal, B., Ashley, E., Chansamouth, V., Basnyat, B., Dunachie, S., Henry, N., Karkey, A., Mayxay, M., Newton, P., Phommasone, K., Pokharel, S., Pollard, A., … Dolecek, C. (2024). Lancet Global Health, 12(3), e406 - e418.
Identification of Burkholderia cepacia strains that express a Burkholderia pseudomallei-like capsular polysaccharide
Burtnick, M., Dance, D., Vongsouvath, M., Newton, P., Dittrich, S., Sendouangphachanh, A., Woods, K., Davong, V., Kenna, D., Saiprom, N., Sengyee, S., Hantrakun, V., Wuthiekanun, V., Limmathurotsakul, D., Chantratita, N., & Brett, P. (2024). Microbiology Spectrum, 12(3).
Diagnosis of human leptospirosis: systematic review and meta-analysis of the diagnostic accuracy of the Leptospira microscopic agglutination test, PCR targeting Lfb1, and IgM ELISA to Leptospira fainei serovar Hurstbridge.
Valente, M., Bramugy, J., Keddie, S., Hopkins, H., Bassat, Q., Baerenbold, O., Bradley, J., Falconer, J., Keogh, R., Newton, P., Picardeau, M., & Crump, J. (2024). BMC Infectious Diseases, 24(1), 168.
Implementing the WHO AWaRe antibiotic book guidance in lower-resource settings: the case of the Lao PDR
Chansamouth, V., Inlorkham, P., Keohavong, B., Bellingham, K., van Doorn, H., Mayxay, M., Newton, P., Turner, P., Day, N., & Ashley, E. (2024). JAC-Antimicrobial Resistance, 6(1).
6 Medical Products Quality and Public Health
Newton, P., & Caillet, C. (2024). In Manson’s Tropical Diseases (pp. 43-48). Elsevier.
Genetic surveillance ofPlasmodium falciparumpopulations following treatment policy revisions in the Greater Mekong Subregion
Wasakul, V., Verschuuren, T., Thuy-Nhien, N., Booth, E., Quang, H., Thang, N., Chindavongsa, K., Sovannaroth, S., Banouvong, V., Sengsavath, V., Mayxay, M., Tuyen, N., Lam Phuong, V., Trung, P., Gonçalves, S., Chen, S., Phalivong, S., Xayvanghang, S., Mahaphontrakoon, S., … Miotto, O. (2024). In medRxiv.