Dr Emmanuelle Bitoun | Infectious Diseases Data Observatory

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Emmanuelle

Bitoun

Senior Operations and Development Manager

Emmanuelle joined the Senior Management Team at IDDO in December 2023. As Senior Operations and Development Manager, she provides leadership to programme management and operations activity across IDDO’s portfolio of infectious disease research themes and data repository. She also oversees the governance of the organisation, and supports its strategic development including funding, communications and partnerships.

Emmanuelle has an MRes in Molecular and Cellular Immunology with a specialisation in Virology from University Paul Sabatier in Toulouse, France. She carried out a PhD in genetics at the WCHG in Oxford, developing the first prenatal diagnosis for a severe congenital immune and skin disorder. She then moved to the MRC Functional Genomics Unit, working in neurosciences on new therapeutic pathways for aggressive forms of blood cancer in children, before joining the Department of Statistics.

In the past 10 years, she managed the strategies, operations, and governance of multidisciplinary programmes in cancer and infertility across experimental and computational biology, including building and leading new research and preclinical validation platforms in academia and the industry.

All Publications

LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome.

Bitoun, E., Micheloni, A., Lamant, L., Bonnart, C., Tartaglia-Polcini, A., Cobbold, C., Cobbold, C., Al Saati, T., Mariotti, F., Mazereeuw-Hautier, J., Boralevi, F., Hohl, D., Harper, J., Bodemer, C., D’Alessio, M., & Hovnanian, A. (2003). Human Molecular Genetics, 12(19), 2417-2430.

Netherton syndrome: disease expression and spectrum of SPINK5 mutations in 21 families.

Bitoun, E., Chavanas, S., Irvine, A., Lonie, L., Bodemer, C., Paradisi, M., Hamel-Teillac, D., Ansai, S.-I., Mitsuhashi, Y., Taïeb, A., de Prost, Y., Zambruno, G., Harper, J., & Hovnanian, A. (2002). The Journal of Investigative Dermatology, 118(2), 352-361.

Prenatal diagnosis of a lethal form of Netherton syndrome by SPINK5 mutation analysis.

Bitoun, E., Bodemer, C., Amiel, J., de Prost, Y., Stoll, C., Calvas, P., & Hovnanian, A. (2002). Prenatal Diagnosis, 22(2), 121-126.

Novel mutations in SPINK5 encoding a serine-protease inhibitor in Netherton syndrome, a severe congenital ichthyosis with hair abnormalities and atopic manifestations.

Bitoun, E., Chavanas, S., Irvine, A., Paradisi, M., Bodemer, C., Hamel-Teillac, D., Lonie, L., Ansai, S., Mitsuhashi, Y., Zimmer, M., de Prost, Y., Zambruno, G., Harper, J., & Hovnanian, A. (2000). AMERICAN JOURNAL OF HUMAN GENETICS, 67(4), 382-382.

A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination

Li, R., Bitoun, E., Altemose, N., Davies, R., Davies, B., & Myers, S. (n.d.). In bioRxiv.

Human PRDM9 can bind and activate promoters, and other zinc-finger proteins associate with reduced recombination in cis

Altemose, N., Noor, N., Bitoun, E., Tumian, A., Imbeault, M., Chapman, J., Aricescu, A., & Myers, S. (n.d.). In bioRxiv.