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Emmanuelle joined the Senior Management Team at IDDO in December 2023. As Senior Operations and Development Manager, she provides leadership to programme management and operations activity across IDDO’s portfolio of infectious disease research themes and data repository. She also oversees the governance of the organisation, and supports its strategic development including funding, communications and partnerships.
Emmanuelle has an MRes in Molecular and Cellular Immunology with a specialisation in Virology from University Paul Sabatier in Toulouse, France. She carried out a PhD in genetics at the WCHG in Oxford, developing the first prenatal diagnosis for a severe congenital immune and skin disorder. She then moved to the MRC Functional Genomics Unit, working in neurosciences on new therapeutic pathways for aggressive forms of blood cancer in children, before joining the Department of Statistics.
In the past 10 years, she managed the strategies, operations, and governance of multidisciplinary programmes in cancer and infertility across experimental and computational biology, including building and leading new research and preclinical validation platforms in academia and the industry.
All Publications
Robotic Mouse
Bitoun, E., Oliver, P., & Davies, K. (2022). In Handbook of the Cerebellum and Cerebellar Disorders (pp. 1667-1684). Springer Nature.
ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair
Bitoun, E., Wells, D., Hinch, A., Moralli, D., Zhang, G., Jankowska, J., Donnelly, P., Green, C., & Myers, S. (2020). ELife, 9.
ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair
Wells, D., Bitoun, E., Moralli, D., Zhang, G., Hinch, A., Jankowska, J., Donnelly, P., Green, C., & Myers, S. (2020). Genetics and Genomics, 9.
Robotic Mouse
Bitoun, E., Oliver, P., & Davies, K. (2020). In Handbook of the Cerebellum and Cerebellar Disorders (pp. 1-18). Springer Nature.
A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination.
Li, R., Bitoun, E., Altemose, N., Davies, R., Davies, B., & Myers, S. (2019). Nature Communications, 1.
A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination
Li, R., Bitoun, E., Altemose, N., Davies, R., Davies, B., & Myers, S. (2019). Nature Communications, 10.
Genetic diversity and its unexpected impacts on recombination, genome evolution, speciation and sterility in mammals
Li, R., Bitoun, E., Altemose, N., Davies, R., Davies, B., & Myers, S. (2019). EUROPEAN JOURNAL OF HUMAN GENETICS, 27, 1073-1073.
A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination
Li, R., Bitoun, E., Altemose, N., Davies, R., Davies, B., & Myers, S. (2018). In bioRxiv.
A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
Altemose, N., Noor, N., Bitoun, E., Tumian, A., Imbeault, M., Chapman, J., Aricescu, A., & Myers, S. (2017). ELife, 6, e28383.
Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice
Davies, B., Hatton, E., Altemose, N., Hussin, J., Pratto, F., Zhang, G., Hinch, A., Moralli, D., Biggs, D., Diaz, R., Preece, C., Li, R., Bitoun, E., Brick, K., Green, C., Camerini-Otero, R., Myers, S., & Donnelly, P. (2016). Nature, 530(2016), 171-176.
A novel mouse model of a patient mucolipidosis II mutation recapitulates disease pathology.
Paton, L., Bitoun, E., Kenyon, J., Priestman, D., Oliver, P., Edwards, B., Platt, F., & Davies, K. (2014). The Journal of Biological Chemistry, 289(39), 26709-26721.
Robotic Mouse
Bitoun, E., Oliver, P., & Davies, K. (2013). In Handbook of the Cerebellum and Cerebellar Disorders (pp. 1481-1497). Springer Nature.
Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
Oliver, P., Finelli, M., Edwards, B., Bitoun, E., Butts, D., Becker, E., Cheeseman, M., Davies, K., & Davies, B. (2011). PLoS Genetics, 7(10).
AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development
Bitoun, E., Finelli, M., Oliver, P., Lee, S., & Davies, K. (2009). Journal of Neuroscience, 29(49), 15366-15374.
The robotic mouse: understanding the role of AF4, a cofactor of transcriptional elongation and chromatin remodelling, in purkinje cell function.
Bitoun, E., & Davies, K. (2009). Cerebellum (London, England), 8(3), 175-183.
PTPRR, cerebellum, and motor coordination.
Schmitt, I., Bitoun, E., & Manto, M. (2009). Cerebellum (London, England), 8(2), 71-73.
The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila.
Vereshchagina, N., Ramel, M.-C., Bitoun, E., & Wilson, C. (2008). Journal of Cell Science, 121(Pt 20), 3383-3392.
Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease.
Oliver, P., Bitoun, E., & Davies, K. (2007). Mammalian Genome : Official Journal of the International Mammalian Genome Society, 18(6-7), 412-424.
Keratitis–ichthyosis–deafness syndrome: disease expression and spectrum of connexin 26 (GJB2) mutations in 14 patients
Mazereeuw‐Hautier, J., Bitoun, E., Chevrant‐Breton, J., Man, S., Bodemer, C., Prins, C., Antille, C., Saurat, J., Atherton, D., Harper, J., Kelsell, D., & Hovnanian, A. (2007). British Journal of Dermatology, 156(5), 1015-1019.
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling.
Bitoun, E., Oliver, P., & Davies, K. (2007). Human Molecular Genetics, 16(1), 92-106.
LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum.
Ishida-Yamamoto, A., Deraison, C., Bonnart, C., Bitoun, E., Robinson, R., O’Brien, T., Wakamatsu, K., Ohtsubo, S., Takahashi, H., Hashimoto, Y., Dopping-Hepenstal, P., McGrath, J., Iizuka, H., Richard, G., & Hovnanian, A. (2005). The Journal of Investigative Dermatology, 124(2), 360-366.
Mediation of Af4 function in the cerebellum by Siah proteins
Bitoun, E., Oliver, P., & Davies, K. (2005). GENETICAL RESEARCH, 86(3), 238-238.
The robotic mouse: unravelling the function of AF4 in the cerebellum.
Bitoun, E., & Davies, K. (2005). Cerebellum (London, England), 4(4), 250-260.
Mediation of Af4 protein function in the cerebellum by Siah proteins.
Oliver, P., Bitoun, E., Clark, J., Jones, E., & Davies, K. (2004). Proc Natl Acad Sci U S A, 101(41), 14901-14906.
Mediation of Af4 protein function in the cerebellum by Siah proteins.
Oliver, P., Bitoun, E., Clark, J., Jones, E., & Davies, K. (2004). Proceedings of the National Academy of Sciences of the United States of America, 101(41), 14901-14906.
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Dr
James
Watson
Associate Director
Co-Lead Malaria Chemoprevention Theme
Email
Research Theme
Malaria
Chagas
WWARN
James Watson joined IDDO in March 2023 as Associate Director.
He is a Sir Henry Dale Fellow funded by the Wellcome Trust working on improving the diagnosis and treatment of severe falciparum malaria.
James is a statistician by training and previously worked at the Mahidol Oxford Tropical Medicine Research Unit in Bangkok for seven years before moving to the Oxford University Clinical Research Unit in Viet Nam.
His research interests also include the radical cure of Plasmodium vivax malaria, SARS-CoV-2 antivirals, Chagas disease, snakebite and adaptive trial design.
Key Publications
Split dosing of artemisinins does not improve antimalarial therapeutic efficacy
White, N., Watson, J., & Ashley, E. (2017). Scientific Reports, 7(12132), 1-5.
Modelling primaquine-induced haemolysis in G6PD deficiency
White, N., Watson, J., Taylor, R., Menard, D., & Kheng, S. (2017). ELife.
Approximate models and robust decisions
Watson, J., & Holmes, C. (2017). Statistical Science, 31(4), 465-489.
All Publications
Accurate measurement of viral clearance in early phase antiviral studies in COVID-19.
Wongnak, P., Watson, J., Jittamala, P., Schilling, W., Seers, T., Leopold, S., & White, N. (2025). J Infect Dis.
Within-host modeling of primaquine-induced hemolysis in hemizygote glucose-6-phosphate dehydrogenase deficient healthy volunteers.
Watson, J., Mehdipour, P., Moss, R., Jittamala, P., Zaloumis, S., Price, D., Dini, S., Hanboonkunupakarn, B., Leungsinsiri, P., Poovorawan, K., Chotivanich, K., Bancone, G., Commons, R., Day, N., Pukrittayakamee, S., Taylor, W., White, N., & Simpson, J. (2025). Antimicrobial Agents and Chemotherapy, 69(4), e0154924.
Tuberculosis preventive therapy: scientific and ethical considerations for trials of ultra-short regimens
Walker, T., Watson, J., Moore, D., Frick, M., & Jamrozik, E. (2025). Lancet Infectious Diseases.
Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV).
Jittamala, P., Boyd, S., Schilling, W., Watson, J., Ngamprasertchai, T., Siripoon, T., Luvira, V., Batty, E., Wongnak, P., Esper, L., Almeida, P., Cruz, C., Ascencao, F., Aguiar, R., Ghanchi, N., Callery, J., Singh, S., Kruabkontho, V., Ngernseng, T., … PLATCOV Collaborative Group. (2025). EClinicalMedicine, 80, 103036.
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2.
Esmaeili, S., Owens, K., Standing, J., Lowe, D., Zhang, S., Watson, J., Schilling, W., Wagoner, J., Polyak, S., & Schiffer, J. (2025).
A protocol for a systematic review and individual patient data meta-analysis investigating the relationship betweenPfkelch13mutations and response to artemisinin-based treatment for uncomplicated falciparum malaria
van Wyk, S., Dahal, P., Christevy Vouvoungui, J., Ayuen, D., Shokraneh, F., Aboubakar, S., Watson, J., Guerin, P., & Barnes, K. (2025). In medRxiv.
Probabilistic classification of late treatment failure in uncomplicated malaria
Mehra, S., Taylor, A., Imwong, M., White, N., & Watson, J. (2025). In medRxiv.
Modeling the within-host dynamics of <i>Plasmodium vivax</i> hypnozoite activation: An analysis of the SPf66 vaccine trial.
Mehra, S., Nosten, F., Luxemburger, C., White, N., & Watson, J. (2024). Proceedings of the National Academy of Sciences of the United States of America, 121(51), e2401024121.
Anakinra for dengue patients with hyperinflammation: protocol for a randomized double-blind placebo-controlled trial
Huyen, T., Trieu, H., Vuong, N., Minh Nguyet, N., Tam, D., McBride, A., Linh, N., Thuan, D., Phong, N., Trung, T., Huong, N., Vien, T., Duyen, H., Hoa, V., Watson, J., Geskus, R., Tho, P., Kestelyn, E., Qui, P., & Yacoub, S. (2024). Wellcome Open Res, 9, 689.
Anakinra for dengue patients with hyperinflammation: protocol for a randomized double-blind placebo-controlled trial.
Huyen, T., Trieu, H., Vuong, N., Minh Nguyet, N., Tam, D., McBride, A., Linh, N., Thuan, D., Phong, N., Trung, T., Huong, N., Vien, T., Duyen, H., Hoa, V., Watson, J., Geskus, R., Tho, P., Kestelyn, E., Qui, P., & Yacoub, S. (2024). Wellcome Open Research, 9, 689.
Methaemoglobin as a surrogate marker of primaquine antihypnozoite activity in Plasmodium vivax malaria: A systematic review and individual patient data meta-analysis
Fadilah, I., Commons, R., Chau, N., Chu, C., Day, N., Koh, G., Green, J., Lacerda, M., Llanos-Cuentas, A., Nelwan, E., Nosten, F., Pasaribu, A., Sutanto, I., Taylor, W., Thriemer, K., Price, R., White, N., Baird, J., & Watson, J. (2024). PLoS Medicine, 21(9).
Advancing the chemotherapy of tuberculous meningitis: a consensus view
Wasserman, S., Donovan, J., Kestelyn, E., Watson, J., Aarnoutse, R., Barnacle, J., Boulware, D., Chow, F., Cresswell, F., Davis, A., Dooley, K., Figaji, A., Gibb, D., Huynh, J., Imran, D., Marais, S., Meya, D., Misra, U., Modi, M., … Wilkinson, R. (2024). Lancet Infectious Diseases, 25(1), e47 - e58.
Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial
Schilling, W., Mukaka, M., Callery, J., Llewelyn, M., Cruz, C., Dhorda, M., Ngernseng, T., Waithira, N., Ekkapongpisit, M., Watson, J., Chandna, A., Nelwan, E., Hamers, R., Etyang, A., Beg, M., Sow, S., Yavo, W., Allabi, A., Basnyat, B., … Tarning, J. (2024). PLoS Medicine, 21(9).
Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites
Siegel, S., Trimarsanto, H., Amato, R., Murie, K., Taylor, A., Sutanto, E., Kleinecke, M., Whitton, G., Watson, J., Imwong, M., Assefa, A., Rahim, A., Nguyen, H., Tran, T., Green, J., Koh, G., White, N., Day, N., Kwiatkowski, D., … Auburn, S. (2024). Nature Communications, 15(1).
Transmission-blocking activities of artesunate, chloroquine, and methylene blue on Plasmodium vivax gametocytes
Chaumeau, V., Wasisakun, P., Watson, J., Oo, T., Aryalamloed, S., Sue, M., Htoo, G., Tha, N., Archusuksan, L., Sawasdichai, S., Gornsawun, G., Mehra, S., White, N., & Nosten, F. (2024). Antimicrobial Agents and Chemotherapy, 68(9).
Rectal artesunate: lives not saved
White, N., Peto, T., & Watson, J. (2024). Transactions of the Royal Society of Tropical Medicine and Hygiene, 118(10), 639-641.
Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV)
Wongnak, P., Schilling, W., Jittamala, P., Boyd, S., Luvira, V., Siripoon, T., Ngamprasertchai, T., Batty, E., Singh, S., Kouhathong, J., Pagornrat, W., Khanthagan, P., Hanboonkunupakarn, B., Poovorawan, K., Mayxay, M., Chotivanich, K., Imwong, M., Pukrittayakamee, S., Ashley, E., … Watson, J. (2024). Lancet Infectious Diseases, 24(9), P953 - 963.
Comparison of WHO versus national COVID-19 therapeutic guidelines across the world: not exactly a perfect match
Cokljat, M., Cruz, C., Carrara, V., Puttaraska, K., Capriglioni, C., Insaurralde, S., Rousseau-Portalis, M., Roldan, A., Watson, J., Tarning, J., White, N., & Guerin, P. (2024). BMJ Global Health, 9(4), e014188.
Where will rectal artesunate suppositories save lives?
Watson, J., Peto, T., & White, N. (2024). Lancet (London, England), 403(10432), 1137-1138.
The burden of tuberculosis in Ho Chi Minh City, Vietnam: a spatial analysis of drug-susceptible and multi-drug resistant cases between 2020 and 2023
Spies, R., Hong, H., Trieu, P., Lan, L., Lan, K., Hue, N., Huong, N., Thao, T., Quang, N., Anh, T., Vinh, T., Dang, T., Phan, T., Nguyen, P., Van, L., Thwaites, G., Nguyen, T., Watson, J., & Walker, T. (2024). Emerging Infectious Diseases, 30(3), 499-509.
The relationship between viral clearance rates and disease progression in early symptomatic COVID-19: a systematic review and meta-regression analysis.
Singh, S., Boyd, S., Schilling, W., Watson, J., Mukaka, M., & White, N. (2024). The Journal of Antimicrobial Chemotherapy, 79(5), 935-945.
Response to comment on 'The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: an individual patient data meta-analysis'
Watson, J., Commons, R., Tarning, J., Simpson, J., Llanos Cuentas, A., Lacerda, M., Green, J., Koh, G., Chu, C., Nosten, F., Price, R., Day, N., & White, N. (2024). ELife, 13.
Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers
Pukrittayakamee, S., Jittamala, P., Watson, J., Hanboonkunupakarn, B., Leungsinsiri, P., Poovorawan, K., Chotivanich, K., Bancone, G., Chu, C., Imwong, M., Day, N., Taylor, W., & White, N. (2024). ELife, 12.
Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers
Pukrittayakamee, S., Jittamala, P., Watson, J., Hanboonkunupakarn, B., Leungsinsiri, P., Poovorawan, K., Chotivanich, K., Bancone, G., Chu, C., Imwong, M., Day, N., Taylor, W., & White, N. (2024). ELife, 12.
Spatial analysis of drug-susceptible and multidrug-resistant cases of tuberculosis, Ho Chi Minh City, Vietnam, 2020-2023
Spies, R., Hong, H., Trieu, P., Lan, L., Lan, K., Hue, N., Huong, N., Thao, T., Quang, N., Anh, T., Vinh, T., Ha, D., Dat, P., Hai, N., Van, L., Thwaites, G., Thuong, N., Watson, J., & Walker, T. (2024). Emerging Infectious Diseases, 30(3), 499-509.
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Professor Philippe Guérin is Director of the Infectious Diseases Data Observatory (IDDO). He was appointed Director of the WorldWide Antimalarial Research Network (WWARN) - the prototypic model for IDDO - in January 2009. Philippe has extensive experience working in the field for Médecins Sans Frontières and as a researcher for a Wellcome Trust Research Unit in many countries in Africa and Asia. Following three years as a Senior Advisor to the Department of Infectious Disease Epidemiology at the Norwegian Institute of Public Health, Philippe joined Épicentre in Paris - a World Health Organization (WHO) Collaborating Centre for Research in epidemiology and response to emerging diseases. Philippe served as Scientific Director for six years at Épicentre before moving to WWARN.