Category
Dr Eulambius Mlugu
Dr
Eulambius
Mlugu
WHO/TDR Fellow in Clinical Research Leadership
Muhimbili University of Health and Allied Sciences/ University of Cape Town
Research Theme
WWARN

Dr Eulambius Mlugu holds a PhD in Clinical Pharmacology from Karolinska Institute, Sweden. He works as a lecturer at Muhimbili University of Health and Allied Sciences (MUHAS) in Dar es Salaam, Tanzania. Dr. Mlugu is a WHO/TDR Fellow in Clinical Research Leadership, working with the MARC SE-Africa team collaborating with WWARN on mitigating antimalarial drug resistance in Southeast Africa. 

His research interests include malaria, neglected tropical diseases (NTDs) and HIV.

Category
Stephanie Van Wyk
Dr
Stephanie
Van Wyk
Senior postdoctoral research fellow
Research Theme
WWARN

Dr Stephanie van Wyk, a molecular biologist and bioinformatician, has made substantial contributions to public health initiatives through her work on Plasmodium, bacteria, viruses, and fungi, working on disease outbreaks such as malaria, COVID-19, and cholera. Her active involvement in pathogen surveillance has influenced disease mitigation in South Africa and across Africa. Currently a research fellow at the University of Cape Town, she contributes her expertise to the Collaborating Centre for Optimising Antimalarial Therapy (CCOAT) and the Mitigating Antimalarial Resistance Consortium for South and East Africa (MARC SEA) within the Department of Medicine, Division of Clinical Pharmacology. Her focus on malaria epidemiology and genetics is in unravelling the disease's complexities and its treatment.

At CCOAT and MARC SE Africa, Dr. van Wyk's work focuses on malaria epidemiology, mitigation, and genetics. She is deeply involved in science communication, advocating for a broader understanding of pathogen research and its implications for malaria mitigation. She is passionate about her work in data science, particularly in optimising and developing web-based technologies to enhance research and public health responses.

Daniel Yilma
Dr
Daniel
Yilma
UCT IDDO post-doctoral fellow
Research Theme
Malaria
WWARN

Daniel Yilma is academician and a practicing Internal Medicine physician in Jimma University Medical Center (JUMC). He obtained his PhD in University of Copenhagen. He established clinical trial unit at JUMC and conducts infectious disease research mainly on HIV, Tuberculosis, COVID-19 and malaria . Daniel joined IDDO/WWARN as a WHO/TDR fellow  and continued his research as a University of Cape Town (UCT) post-doctoral fellow within the Southern African Centre of IDDO based at the UCT Collaborating Centre for Optimising Antimalarial Therapy. He serves as member of malaria case management team at national level. He continues to work with WWARN and other collaborators to find safe, effective and simplified malaria treatment and diagnostic tools.

 

Category
Professor Feiko ter Kuile
Professor
Feiko
Kuile
Head of Malaria in Pregnancy Scientific Group
Research Theme
Malaria
WWARN

Prof Feiko ter Kuile joined WWARN in 2016 as Head of the Malaria in Pregnancy Scientific Group. He is Professor of Clinical Tropical Medicine at the Liverpool School of Tropical Medicine. Prof ter Kuile is a clinical epidemiologist who trained in medicine at the Academic Medical Centre of the University of Amsterdam. He previously worked at the Shoklo Malaria Research Unit (SMRU), the University of Amsterdam, and Mahidol University. Prof ter Kuile then worked with the Centers for Disease Control and Prevention (CDC), first as a research epidemiologist at the CDC field station in Kisumu, Western Kenya for 6 years, then as a senior medical epidemiologist based in Atlanta, GA, USA for 2 years. Since 2007, Prof ter Kuile has led the Malaria in Pregnancy Consortium at the Liverpool School of Tropical Medicine (LSTM), and is currently based at the Centre for Global Health Research, Kenya Medical Research Institute (KEMRI) in Kisumu. His main research interests include the epidemiology of malaria and the evaluation of new interventions for the control of malaria in children and pregnant women. 

Category
Professor Ric Price
Professor
Ric
Price
Head of Clinical Group
Research Theme
Malaria
WWARN

Prof Ric Price was appointed Head of the Clinical Group in WWARN in 2007. He is an infectious disease physician currently on the staff at the Royal Darwin Hospital, Australia, and an honorary consultant at the John Radcliffe Hospital, Oxford. Ric was appointed Professor of Tropical Medicine at the University of Oxford in 2011 and and Professor of Global Health at the Menzies School of Health Research in Darwin, Australia in 2010. The focus of his academic work is the investigation of multidrug resistant malaria and devising strategies for its containment.  He coordinates a field site in Papua, Indonesia investigating the diagnosis and management of drug resistant P. falciparum and P. vivax. This work spans clinical studies, epidemiology, pathophysiology, in vitro studies and molecular biology.  Ric also chairs the Vivax Working Group of the Asia Pacific Malaria Elimination Network (APMEN).

Key Publications

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia
Grist, E., Flegg, J., Humphreys, G., Mas, I., Ashley, E., Humphreys, G., Dhorda, M., Dondorp, A., Hien, T., Maude, R., Mayxay, M., Nosten, F., Newton, P., Price, R., Smithuis, F., White, N., Woodrow, C., Guerin, P., & Gething, P. (2016). International Journal of Health Geographics, 15(37), 1-10.
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Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis
Abdulla, S., Ashley, E., Bassat, Q., Bethell, D., Bjorkman, A., Borrmann, S., D’Alessandro, U., Dahal, P., Day, N., Diakite, M., Djimde, A., Dondorp, A., Duong, S., Edstein, Fairhurst, R., Faiz, M., Falade, C., Flegg, J., Fogg, C., … Winstanley, P. (2015). Malaria Journal, 14(1).
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Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.
Venkatesan, M., Gadalla, N., Stepniewska, K., Dahal, P., Nsanzabana, C., Moriera, C., Price, R., Mårtensson, A., Rosenthal, P., Dorsey, G., Sutherland, C., Guérin, P., Davis, T., Ménard, D., Adam, I., Ademowo, G., Arze, C., Baliraine, F., Berens-Riha, N., … Ogutu, B. (2014). American Journal of Tropical Medicine and Hygiene, 91(4), 833-843.
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All Publications

Methaemoglobin as a surrogate marker of primaquine antihypnozoite activity in Plasmodium vivax malaria: A systematic review and individual patient data meta-analysis
Fadilah, I., Commons, R., Chau, N., Chu, C., Day, N., Koh, G., Green, J., Lacerda, M., Llanos-Cuentas, A., Nelwan, E., Nosten, F., Pasaribu, A., Sutanto, I., Taylor, W., Thriemer, K., Price, R., White, N., Baird, J., & Watson, J. (2024). PLoS Medicine, 21(9).
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Primaquine for uncomplicated Plasmodium vivax malaria in children younger than 15 years: a systematic review and individual patient data meta-analysis.
Commons, R., Rajasekhar, M., Allen, E., Yilma, D., Chotsiri, P., Abreha, T., Adam, I., Awab, G., Barber, B., Brasil, L., Chu, C., Cui, L., Edler, P., Gomes, M., Gonzalez-Ceron, L., Grigg, M., Hamid, M., Hwang, J., Karunajeewa, H., … WorldWide Antimalarial Resistance Network Paediatric Primaquine Vivax Study Group. (2024). The Lancet. Child & Adolescent Health, 8(11), 798-808.
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Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites
Siegel, S., Trimarsanto, H., Amato, R., Murie, K., Taylor, A., Sutanto, E., Kleinecke, M., Whitton, G., Watson, J., Imwong, M., Assefa, A., Rahim, A., Nguyen, H., Tran, T., Green, J., Koh, G., White, N., Day, N., Kwiatkowski, D., … Auburn, S. (2024). Nature Communications, 15(1).
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A randomised controlled trial to compare the efficacy, safety, and tolerability of low dose, short course primaquine in adults with uncomplicated P. vivax malaria in two hospitals in India
Ahmad, S., Verma, R., Commons, R., Nitika, Singh-Phulgenda, S., Chhajed, R., Bharti, P., Behera, B., Naser, S., Pal, S., Ranjit, P., Baharia, R., Solanki, B., Upadhyay, K., Guerin, P., Sharma, A., Price, R., Rahi, M., & Thriemer, K. (2024). Trials, 25(1).
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Response to comment on 'The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: an individual patient data meta-analysis'
Watson, J., Commons, R., Tarning, J., Simpson, J., Llanos Cuentas, A., Lacerda, M., Green, J., Koh, G., Chu, C., Nosten, F., Price, R., Day, N., & White, N. (2024). ELife, 13.
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Methaemoglobin as a surrogate marker of primaquine antihypnozoite activity inPlasmodium vivaxmalaria: a systematic review and individual patient data meta-analysis
Fadilah, I., Commons, R., Chau, N., Chu, C., Day, N., Koh, G., Green, J., Lacerda, M., Llanos-Cuentas, A., Nelwan, E., Nosten, F., Pasaribu, A., Sutanto, I., Taylor, W., Thriemer, K., Price, R., White, N., Baird, K., & Watson, J. (2024). In medRxiv.
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Safety and efficacy of primaquine in patients with Plasmodium vivax malaria from South Asia: a systematic review and individual patient data meta-analysis
Verma, R., Commons, R., Gupta, A., Rahi, M., Nitika, Bharti, P., Thriemer, K., Rajasekhar, M., Singh-Phulgenda, S., Adhikari, B., Alam, M., Ghimire, P., Khan, W., Kumar, R., Leslie, T., Ley, B., Llanos-Cuentas, A., Pukrittayakamee, S., Rijal, K., … Sharma, A. (2023). BMJ Global Health, 8(12).
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Effect of adherence to primaquine on the risk of Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Mehdipour, P., Rajasekhar, M., Dini, S., Zaloumis, S., Abreha, T., Adam, I., Awab, G., Baird, J., Brasil, L., Chu, C., Cui, L., Daher, A., do Socorro M Gomes, M., Gonzalez-Ceron, L., Hwang, J., Karunajeewa, H., Lacerda, M., Ladeia-Andrade, S., Leslie, T., … Commons, R. (2023). Malaria Journal, 22(1).
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Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis
Commons, R., Rajasekhar, M., Edler, P., Abreha, T., Awab, G., Baird, J., Barber, B., Chu, C., Cui, L., Daher, A., Gonzalez-Ceron, L., Grigg, M., Hwang, J., Karunajeewa, H., Lacerda, M., Ladeia-Andrade, S., Lidia, K., Llanos-Cuentas, A., Longley, R., … Price, R. (2023). Lancet Infectious Diseases, 24(2), 172-183.
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Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis
Rajasekhar, M., Simpson, J., Ley, B., Edler, P., Chu, C., Abreha, T., Awab, G., Baird, J., Bancone, G., Barber, B., Grigg, M., Hwang, J., Karunajeewa, H., Lacerda, M., Ladeia-Andrade, S., Llanos-Cuentas, A., Pukrittayakamee, S., Rijal, K., Saravu, K., … Price, R. (2023). Lancet Infectious Diseases, 24(2), 184-195.
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Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial Resistance Network individual patient data meta-analysis
Price, R. (2023). Malaria Journal, 22(1).
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Lineage-informative microhaplotypes for spatio-temporal surveillance of Plasmodium vivax malaria parasites.
Siegel, S., Amato, R., Trimarsanto, H., Sutanto, E., Kleinecke, M., Murie, K., Whitton, G., Taylor, A., Watson, J., Imwong, M., Assefa, A., Rahim, A., Chau, N., Hien, T., Green, J., Koh, G., White, N., Day, N., Kwiatkowski, D., … Auburn, S. (2023). MedRxiv, 4(03-29), 2023.03.13.23287179.
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The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: an individual patient data meta-analysis
Watson, J., Commons, R., Tarning, J., Simpson, J., Llanos Cuentas, A., Lacerda, M., Green, J., Koh, G., Chu, C., Nosten, F., Price, R., Day, N., & White, N. (2022). ELife, 11.
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Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data
Stepniewska, K., Allen, E., Humphreys, G., Poirot, E., Craig, E., Kennon, K., Yilma, D., Bousema, T., Guerin, P., White, N., Price, R., Raman, J., Martensson, A., Mwaiswelo, R., Bancone, G., Bastiaens, G., Bjorkman, A., Brown, J., D’Alessandro, U., … Chen, I. (2022). BMC Medicine, 20.
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Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning
Das, D., Vongpromek, R., Assawariyathipat, T., Srinamon, K., Kennon, K., Stepniewska, K., Ghose, A., Sayeed, A., Faiz, M., Netto, R., Siqueira, A., Yerbanga, S., Ouédraogo, J., Callery, J., Peto, T., Tripura, R., Koukouikila-Koussounda, F., Ntoumi, F., Ong’echa, J., … Dhorda, M. (2022). Malaria Journal, 21.
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Cooperation in countering artemisinin resistance in Africa: learning from COVID-19
Rosenthal, P., Björkman, A., Dhorda, M., Djimde, A., Dondorp, A., Gaye, O., Guerin, P., Juma, E., Kwiatkowski, D., Merson, L., Ntoumi, F., Price, R., Raman, J., Roos, D., Ter Kuile, F., Tinto, H., Tomko, S., White, N., & Barnes, K. (2022). American Journal of Tropical Medicine and Hygiene, 106(6), 1568-1570.
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Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis
Dahal, P., Simpson, J., Abdulla, S., Ashley, E., Carrara, V., Fanello, C., Hien, H., & Price, R. (2022). Malaria Journal, 21.
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The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: an individual patient data meta-analysis
Watson, J., Commons, R., Tarning, J., Simpson, J., Cuentas, A., Lacerda, M., Green, J., Koh, G., Chu, C., H Nosten, F., Price, R., Day, N., & White, N. (2022). In medRxiv.
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The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network
Hossain, M., Commons, R., Douglas, N., Thriemer, K., Alemayehu, B., Amaratunga, C., Anvikar, A., Ashley, E., Asih, P., Carrara, V., Lon, C., D’Alessandro, U., Davis, T., Dondorp, A., Edstein, M., Fairhurst, R., Ferreira, M., Hwang, J., Janssens, B., … Price, R. (2020). PLOS Medicine, 17(11).
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Towards harmonization of microscopy methods for malaria clinical research studies
Dhorda, M., Ba, E., Kevin Baird, J., Barnwell, J., Bell, D., Carter, J., Dondorp, A., Ekawati, L., Gatton, M., González, I., Guérin, P., Incardona, S., Lilley, K., Menard, D., Nosten, F., Obare, P., Ogutu, B., Olliaro, P., Price, R., … Sokhna, C. (2020). Malaria Journal, 19(1).
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Efficacy of single dose primaquine with artemisinin combination therapy on P. falciparum gametocytes and transmission: A WWARN individual patient meta-analysis
Stepniewska, K., Humphreys, G., Gonçalves, B., Craig, E., Gosling, R., Guerin, P., Price, R., Barnes, K., Raman, J., Smit, M., D’Alessandro, U., Stone, W., Bjorkman, A., Samuels, A., Arroyo-Arroyo, M., Bastiaens, G., Brown, J., Dicko, A., El-Sayed, B., … Bousema, T. (2020). Journal of Infectious Diseases, 225(7), 1215-1226.
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Estimating the proportion of plasmodium vivax recurrences caused by relapse: A systematic review and meta-analysis
Commons, R., Simpson, J., Watson, J., White, N., & Price, R. (2020). American Journal of Tropical Medicine and Hygiene.
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Baseline results of a living systematic review for COVID-19 clinical trial registrations
Maguire, B., McLean, A., Rashan, S., Antonio, E., Bagaria, J., Bentounsi, Z., Brack, M., Caldwell, F., Carrara, V., Citarella, B., Dahal, P., Feteh, V., Guérin, M., Kennon, K., Bilton Lahaut, K., Makuka, G., Ngu, R., Obiesie, S., Richmond, C., … Guérin, P. (2020). Wellcome Open Research, 5.
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The worldwide antimalarial resistance network clinical trials publication library: A live, open-access database of plasmodium treatment efficacy trials
Takata, J., Sondo, P., Humphreys, G., Burrow, R., Maguire, B., Hossain, M., Das, D., Commons, R., Price, R., & Guerin, P. (2020). American Journal of Tropical Medicine and Hygiene.
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Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting
Dahal, P., Stepniewska, K., Guerin, P., D’Alessandro, U., Price, R., & Simpson, J. (2019). BMC Medical Research Methodology, 19.
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