Professor
Philippe
Guérin
Ebola SC Member
Oxford University
After working as a physician in France and Nepal, Philippe joined Médecins Sans Frontières where he gained extensive experience of working in the field and as a researcher working on malaria and tuberculosis. He spent six years as the Scientific Director of Epicentre in Paris, a World Health Organization Collaborating Centre for Research in Epidemiology and Response to Emerging Diseases. Prior to this, he spent three years as a senior advisor at the Norwegian Institute of Public Health.
Philippe is Director of the Infectious Diseases Data Observatory (IDDO), which collates and pools clinical, laboratory and epidemiological data on select poverty-related diseases and emerging infections. IDDO is building upon the success of the WorldWide Antimalarial Resistance Network (WWARN), a scientifically independent, multi-disciplinary platform, founded in 2009 to provide the information necessary to prevent or alleviate antimalarial drug resistance and therefore reduce malaria morbidity and mortality.
Key Publications
Pregnancy outcomes after first-trimester treatment with artemisinin derivatives versus non-artemisinin antimalarials: a systematic review and individual patient data meta-analysis
Saito, M., McGready, R., Tinto, H., Rouamba, T., Mosha, D., Rulisa, S., Kariuki, S., Desai, M., Manyando, C., Njunju, E., Sevene, E., Vala, A., Augusto, O., Clerk, C., Were, E., Mrema, S., Kisinza, W., Byamugisha, J., Kagawa, M., … Dellicour, S. (2022). The Lancet, 401(10371), 118-130.
Guidelines should not pool evidence from uncomplicated and severe COVID-19
White, N., Strub-Wourgaft, N., Faiz, A., & Guerin, P. (2021). Lancet, 397(10281), 1262-1263.
Gender disparity in cases enrolled in clinical trials of visceral leishmaniasis: A systematic review and meta-analysis
Dahal, P., Singh-Phulgenda, S., Olliaro, P., & Guerin, P. (2021). PLoS Neglected Tropical Diseases, 15(3).
Non-malarial febrile illness: a systematic review of published aetiological studies and case reports from Southern Asia and South-eastern Asia, 1980-2015
Shrestha, P., Dahal, P., Ogbonnaa-Njoku, C., Das, D., Stepniewska, K., Thomas, N., Hopkins, H., Crump, J., Bell, D., Newton, P., Ashley, E., & Guérin, P. (2020). BMC Medicine, 18.
Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Saito, M., Mansoor, R., Kennon, K., Anvikar, A., Ashley, E., Chandramohan, D., Cohee, L., D’Alessandro, U., Genton, B., Gilder, M., Juma, E., Kalilani-Phiri, L., Kuepfer, I., Laufer, M., Lwin, K., Meshnick, S., Mosha, D., Muehlenbachs, A., Mwapasa, V., … Guérin, P. (2020). BMC Medicine, 18(1).
Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis
Ashley, E., Dhorda, M., Dondorp, A., Fanello, C., Guérin, P., Humphreys, G., Kennon, K., Mayxay, M., Nosten, F., Phyo, A., Sibley, C., Sondo, P., Stepniewska, K., White, N., & Woodrow, C. (2019). BMC Medicine, 1(17).
Systematic review of clinical trials assessing the therapeutic efficacy of visceral leishmaniasis treatments: A first step to assess the feasibility of establishing an individual patient data sharing platform
Bush, J., Wasunna, M., Alves, F., Alvar, J., Olliaro, P., Otieno, M., Sibley, C., Strub Wourgaft, N., & Guerin, P. (2017). PLoS Neglected Tropical Diseases, 11(9), e0005781.
Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia
Grist, E., Flegg, J., Humphreys, G., Mas, I., Ashley, E., Humphreys, G., Dhorda, M., Dondorp, A., Hien, T., Maude, R., Mayxay, M., Nosten, F., Newton, P., Price, R., Smithuis, F., White, N., Woodrow, C., Guerin, P., & Gething, P. (2016). International Journal of Health Geographics, 15(37), 1-10.
Beyond open data: realising the health benefits of sharing data
Pisani, E., Aaby, P., Breugelmans, J., Carr, D., Groves, T., Helinski, M., Kamuya, D., Kern, S., Littler, K., Marsh, V., Mboup, S., Merson, L., Sankoh, O., Serafini, M., Schneider, M., Schoenenberger, V., & Guerin, P. (2016). BMJ.
The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data.
(2015). Lancet. Infectious Diseases, 6.
Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker
Tun, K., Imwong, M., Lwin, K., Win, A., Hlaing, T., Hlaing, T., Lin, K., Kyaw, M., Plewes, K., Faiz, M., Dhorda, M., Cheah, P., Pukrittayakamee, S., Ashley, E., Anderson, T., Nair, S., McDew-White, M., Flegg, J., Grist, E., … Woodrow, C. (2015). The Lancet Infectious Diseases, 15(4), 415-421.
Quality assurance of drugs used in clinical trials: proposal for adapting guidelines
Newton, P., Schellenberg, D., Ashley, E., Ravinetto, R., Green, M., ter Kuile, F., Tabernero, P., White, N., & Guerin, P. (2015). BMJ, 350.
Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data
Abdulla, S., Adam, I., Adjei, G., Adjuik, M., Alemayehu, B., Allan, R., Arinaitwe, E., Ashley, E., Barennes, H., Barnes, K., Bassat, Q., Baudin, E., Berens-Riha, N., Bjoerkman, A., Bompart, F., Bonnet, M., Borrmann, S., Bousema, T., Brasseur, P., … Gonzalez, R. (2015). BMC Medicine, 13(1).
Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data
Abdulla, S., Adam, I., Adjei, G., Adjuik, M., Alemayehu, B., Allan, R., Arinaitwe, E., Ashley, E., Barennes, H., Barnes, K., Bassat, Q., Baudin, E., Berens-Riha, N., Bjoerkman, A., Bompart, F., Bonnet, M., Borrmann, S., Bousema, T., Brasseur, P., … Gonzalez, R. (2015). BMC Medicine, 13(1).
Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis
Abdulla, S., Ashley, E., Bassat, Q., Bethell, D., Bjorkman, A., Borrmann, S., D’Alessandro, U., Dahal, P., Day, N., Diakite, M., Djimde, A., Dondorp, A., Duong, S., Edstein, Fairhurst, R., Faiz, M., Falade, C., Flegg, J., Fogg, C., … Winstanley, P. (2015). Malaria Journal, 14(1).
The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data
Adjuik, M., Allan, R., Anvikar, A., Ashley, E., Barennes, H., Barnes, K., Bassat, Q., Baudin, E., Bjorkman, A., Bompart, F., Bonnet, M., Borrmann, S., Brasseur, P., Bukirwa, H., Checchi, F., Cot, M., Dahal, P., D’Alessandro, U., Deloron, P., … Ibrahim, L. (2015). BMC Medicine, 13(1).
Spread of artemisinin resistance in Plasmodium falciparum malaria.
Ashley, E., Dhorda, M., Fairhurst, R., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J., Mao, S., Sam, B., Sopha, C., Chuor, C., Nguon, C., Sovannaroth, S., Pukrittayakamee, S., Jittamala, P., Chotivanich, K., Chutasmit, K., Suchatsoonthorn, C., … Tracking Resistance to Artemisinin Collaboration (TRAC). (2014). The New England Journal of Medicine, 371(5), 411-423.
Spread of artemisinin resistance in Plasmodium falciparum malaria.
Ashley, E., Dhorda, M., Fairhurst, R., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J., Mao, S., Sam, B., Sopha, C., Chuor, C., Nguon, C., Sovannaroth, S., Pukrittayakamee, S., Jittamala, P., Chotivanich, K., Chutasmit, K., Suchatsoonthorn, C., … Tracking Resistance to Artemisinin Collaboration (TRAC). (2014). The New England Journal of Medicine, 371(5), 411-423.
Benefits of a pharmacology antimalarial reference standard and proficiency testing program provided by the Worldwide Antimalarial Resistance Network (WWARN).
Lourens, C., Lindegardh, N., Barnes, K., Guerin, P., Sibley, C., White, N., & Tarning, J. (2014). Antimicrobial Agents and Chemotherapy, 58(7), 3889-3894.
Mind the gaps--the epidemiology of poor-quality anti-malarials in the malarious world--analysis of the WorldWide Antimalarial Resistance Network database.
Tabernero, P., Fernández, F., Green, M., Guerin, P., & Newton, P. (2014). Malaria Journal, 13, 139.
Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections.
Taylor, A., Flegg, J., Nsobya, S., Yeka, A., Kamya, M., Rosenthal, P., Dorsey, G., Sibley, C., Guerin, P., & Holmes, C. (2014). Malaria Journal, 13, 102.
The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
Achan, J., Adam, I., Arinaitwe, E., Ashley, E., Awab, G., Barnes, K., Bassat, Q., Borrmann, S., Bousema, T., Dahal, P., D’Alessandro, U., Davis, T., Dondorp, A., Dorsey, G., Drakeley, C., Fanello, C., Faye, B., Flegg, J., Gaye, O., … Phyo, A. (2013). PLOS MEDICINE, 10(12), 1-17.
The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
Achan, J., Adam, I., Arinaitwe, E., Ashley, E., Awab, G., Barnes, K., Bassat, Q., Borrmann, S., Bousema, T., Dahal, P., D’Alessandro, U., Davis, T., Dondorp, A., Dorsey, G., Drakeley, C., Fanello, C., Faye, B., Flegg, J., Gaye, O., … Phyo, A. (2013). PLOS MEDICINE, 10(12), 1-17.
Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives
Flegg, J., Guérin, P., Nosten, F., Ashley, E., Phyo, A., Dondorp, A., Fairhurst, R., Socheat, D., Borrmann, S., Björkman, A., Mårtensson, A., Mayxay, M., Newton, P., Bethell, D., Se, Y., Noedl, H., Diakite, M., Djimde, A., Hien, T., … Stepniewska, K. (2013). Malaria Journal, 12.
Trends in antimalarial drug use in Africa.
Flegg, J., Metcalf, C., Gharbi, M., Venkatesan, M., Shewchuk, T., Hopkins Sibley, C., & Guerin, P. (2013). Am J Trop Med Hyg, 89(5), 857-865.
All Publications
Investigating the relationship between Pfkelch13 mutations and response to artemisinin-based treatment for uncomplicated falciparum malaria: a protocol for a systematic review and individual patient data meta-analysis
van Wyk, S., Dahal, P., Vouvoungui, C., Ayuen, D., Shokraneh, F., Soma, A., Watson, J., Guerin, P., & Barnes, K. (2025). BMJ Open, 15(7), e100251.
Factors affecting integration of an early warning system for antimalarial drug resistance within a routine surveillance system in a pre-elimination setting in Sub-Saharan Africa
Kagoro, F., Allen, E., Raman, J., Mabuza, A., Magagula, R., Kok, G., Malatje, G., Guerin, P., Dhorda, M., Maude, R., & Barnes, K. (2025). PLoS ONE, 20(6).
Efficacy of artemisinin-based combination therapy (ACT) in people living with HIV (PLHIV) diagnosed with uncomplicated Plasmodium falciparum malaria in Africa: a WWARN systematic review.
Takyi, A., Soma, A., Przybylska, M., Harriss, E., Barnes, K., Dahal, P., Guérin, P., Stepniewska, K., & Carrara, V. (2025). Malaria Journal, 24(1), 153.
Safety and efficacy of single-dose primaquine to interrupt Plasmodium falciparum malaria transmission in children compared with adults: a systematic review and individual patient data meta-analysis.
Yilma, D., Stepniewska, K., Bousema, T., Drakeley, C., Eachempati, P., Guerin, P., Mårtensson, A., Mwaiswelo, R., Taylor, W., Barnes, K., & WWARN Paediatric Primaquine for P falciparum Transmission Blocking Study Group. (2025). The Lancet. Infectious Diseases, S1473 - 3099(25)00078.
Defining the noma research agenda
Galli, A., Comparet, M., Dagne, D., Baratti-Mayer, D., Cao, T., Guérin, P., Guevara, M., Hetzel, M., Jeantet, C., Mpinga, E., Muendane, V., Okanlawon, M., Placella, E., Ribes, M., Sherlock, M., Utzinger, J., & Steinmann, P. (2025). PLoS Neglected Tropical Diseases, 19(4).
Wrangling Real-World Data: Optimizing Clinical Research Through Factor Selection with LASSO Regression.
Howard, K., Anderson, W., Podichetty, J., Gould, R., Boyce, D., Dasher, P., Evans, L., Kao, C., Kumar, V., Hamilton, C., Mathé, E., Guerin, P., Dodd, K., Mehta, A., Ortman, C., Patil, N., Rhodes, J., Robinson, M., Stone, H., & Heavner, S. (2025). International Journal of Environmental Research and Public Health, 22(4), 464.
Prevalence of asymptomatic parasitaemia among household members of children under seasonal malaria chemoprevention coverage and comparison of the performance of standard rapid diagnostic tests versus ultrasensitive RDT for the detection of asymptomatic parasitaemia in Nanoro, Burkina Faso
Kambou, S., Millogo, K., Sondo, P., Kabore, B., Kouevi, A., Bouda, I., Rouamba, T., Derra, K., Tahita, M., Ilboudo, H., Rouamba, E., Tougri, G., Otienoburu, S., Dhorda, M., Bamba, S., Guerin, P., & Tinto, H. (2024). Parasitology Research, 123(11).
Primaquine for uncomplicated Plasmodium vivax malaria in children younger than 15 years: a systematic review and individual patient data meta-analysis.
Commons, R., Rajasekhar, M., Allen, E., Yilma, D., Chotsiri, P., Abreha, T., Adam, I., Awab, G., Barber, B., Brasil, L., Chu, C., Cui, L., Edler, P., Gomes, M., Gonzalez-Ceron, L., Grigg, M., Hamid, M., Hwang, J., Karunajeewa, H., … WorldWide Antimalarial Resistance Network Paediatric Primaquine Vivax Study Group. (2024). The Lancet. Child & Adolescent Health, 8(11), 798-808.
Non-malarial febrile illness: a systematic review of published aetiological studies and case reports from China, 1980–2015
Ip, D., Ng, Y., Tam, Y., Thomas, N., Dahal, P., Stepniewska, K., Newton, P., Guérin, P., & Hopkins, H. (2024). BMC Infectious Diseases, 24(1).
Blood transfusion in the care of patients with visceral leishmaniasis: a review of practices in therapeutic efficacy studies.
Dahal, P., Singh-Phulgenda, S., Wilson, J., Cota, G., Ritmeijer, K., Musa, A., Alves, F., Stepniewska, K., & Guerin, P. (2024). Transactions of the Royal Society of Tropical Medicine and Hygiene, 118(8), 481-490.
Design, Conduct, Analysis, and Reporting of Therapeutic Efficacy Studies in Visceral Leishmaniasis: A Systematic Review of Published Reports, 2000-2021.
Dahal, P., Singh-Phulgenda, S., Naylor, C., Brack, M., Chatterjee, M., Alves, F., Guerin, P., & Stepniewska, K. (2024). The American Journal of Tropical Medicine and Hygiene, 111(2), 365-376.
Systematic Review and Geospatial Modeling of Molecular Markers of Resistance to Artemisinins and Sulfadoxine-Pyrimethamine in Plasmodium falciparum in India.
Nain, M., Dhorda, M., Flegg, J., Gupta, A., Harrison, L., Singh-Phulgenda, S., Otienoburu, S., Harriss, E., Bharti, P., Behera, B., Rahi, M., Guerin, P., & Sharma, A. (2024). The American Journal of Tropical Medicine and Hygiene, 110(5), 910-920.
Comparison of WHO versus national COVID-19 therapeutic guidelines across the world: not exactly a perfect match
Cokljat, M., Cruz, C., Carrara, V., Puttaraska, K., Capriglioni, C., Insaurralde, S., Rousseau-Portalis, M., Roldan, A., Watson, J., Tarning, J., White, N., & Guerin, P. (2024). BMJ Global Health, 9(4), e014188.
Post-kala-azar dermal leishmaniasis (PKDL) drug efficacy study landscape: A systematic scoping review of clinical trials and observational studies to assess the feasibility of establishing an individual participant-level data (IPD) platform
Singh-Phulgenda, S., Kumar, R., Dahal, P., Munir, A., Rashan, S., Chhajed, R., Naylor, C., Maguire, B., Siddiqui, N., Harriss, E., Rahi, M., Alves, F., Sundar, S., Stepniewska, K., Musa, A., Guerin, P., & Pandey, K. (2024). PLoS Neglected Tropical Diseases, 18(4).
Spatio-temporal spread of artemisinin resistance in Southeast Asia
Flegg, J., Kandanaarachchi, S., Guerin, P., Dondorp, A., Nosten, F., Otienoburu, S., & Golding, N. (2024). PLoS Computational Biology, 20(4).
Does acute malnutrition in young children increase the risk of treatment failure following artemisinin-based combination therapy? A WWARN individual patient data meta-analysis.
WWARN ACT Malaria and Malnutrition Study Group. (2024). The Lancet. Global Health, 12(4), e631 - e640.
Estimating the proportion of relapse following treatment of Visceral Leishmaniasis: meta-analysis using Infectious Diseases Data Observatory (IDDO) systematic review.
Chhajed, R., Dahal, P., Singh-Phulgenda, S., Brack, M., Naylor, C., Sundar, S., Alves, F., Stepniewska, K., & Guerin, P. (2024). The Lancet Regional Health. Southeast Asia, 22, 100317.
A randomised controlled trial to compare the efficacy, safety, and tolerability of low dose, short course primaquine in adults with uncomplicated P. vivax malaria in two hospitals in India
Ahmad, S., Verma, R., Commons, R., Nitika, Singh-Phulgenda, S., Chhajed, R., Bharti, P., Behera, B., Naser, S., Pal, S., Ranjit, P., Baharia, R., Solanki, B., Upadhyay, K., Guerin, P., Sharma, A., Price, R., Rahi, M., & Thriemer, K. (2024). Trials, 25(1).
Factors Affecting Integration of an Early Warning System for Antimalarial Drug Resistance within a Routine Surveillance System in a Pre-elimination Setting in Sub-Saharan Africa
Kagoro, F., Allen, E., Raman, J., Mabuza, A., Magagula, R., Kok, G., Malatje, G., Guerin, P., Dhorda, M., Maude, R., & Barnes, K. (2024). In medRxiv.
The lymphatic filariasis treatment study landscape: A systematic review of study characteristics and the case for an individual participant data platform.
Freitas, L., Khan, M., Uddin, A., Halder, J., Singh-Phulgenda, S., Raja, J., Balakrishnan, V., Harriss, E., Rahi, M., Brack, M., Guérin, P., Basáñez, M.-G., Kumar, A., Walker, M., & Srividya, A. (2024). PLoS Neglected Tropical Diseases, 18(1), e0011882.
Quantifying anti-trypanosomal treatment effects in chronic indeterminate Chagas disease: an individual patient data meta-analysis of two proof of concept trials
Watson, J., Cruz, C., Barreira, F., Forsyth, C., Schijman, A., Peploe, R., Assmus, F., Naylor, C., Lee, J., Mehra, S., Tarning, J., Torrico, F., Gascon, J., Ortiz, L., Ribeiro, I., Sosa-Estani, S., Tipple, C., Hugonnet, S., Guérin, P., … White, N. (2024). In medRxiv.
Safety and efficacy of primaquine in patients with Plasmodium vivax malaria from South Asia: a systematic review and individual patient data meta-analysis
Verma, R., Commons, R., Gupta, A., Rahi, M., Nitika, Bharti, P., Thriemer, K., Rajasekhar, M., Singh-Phulgenda, S., Adhikari, B., Alam, M., Ghimire, P., Khan, W., Kumar, R., Leslie, T., Ley, B., Llanos-Cuentas, A., Pukrittayakamee, S., Rijal, K., … Sharma, A. (2023). BMJ Global Health, 8(12).
PA-340 A systematic review of the efficacy of artemisinin-based combination therapy (ACT) in people living with HIV (PLHIV) diagnosed with uncomplicated Plasmodium falciparum malaria in Africa
Takyi, A., Soma, A., Przybylska, M., Harriss, E., Carrara, V., Barnes, K., Dahal, P., Guérin, P., & Stepniewska, K. (2023). a67.1 - a6a67.
Haematological dynamics following treatment of visceral leishmaniasis: a protocol for systematic review and individual participant data (IPD) meta-analysis.
Munir, A., Dahal, P., Kumar, R., Singh-Phulgenda, S., Siddiqui, N., Naylor, C., Wilson, J., Buck, G., Rahi, M., Alves, F., Malaviya, P., Sundar, S., Ritmeijer, K., Stepniewska, K., Pandey, K., Guérin, P., & Musa, A. (2023). BMJ Open, 13(12), e074841.
Characterisation of populations at risk of sub-optimal dosing of artemisinin-based combination therapy in Africa
Takyi, A., Carrara, V., Dahal, P., Przybylska, M., Harriss, E., Insaidoo, G., Barnes, K., Guerin, P., & Stepniewska, K. (2023). PLOS Global Public Health, 3(12), e0002059.