Professor
Philippe
Guérin
Ebola SC Member
Oxford University
After working as a physician in France and Nepal, Philippe joined Médecins Sans Frontières where he gained extensive experience of working in the field and as a researcher working on malaria and tuberculosis. He spent six years as the Scientific Director of Epicentre in Paris, a World Health Organization Collaborating Centre for Research in Epidemiology and Response to Emerging Diseases. Prior to this, he spent three years as a senior advisor at the Norwegian Institute of Public Health.
Philippe is Director of the Infectious Diseases Data Observatory (IDDO), which collates and pools clinical, laboratory and epidemiological data on select poverty-related diseases and emerging infections. IDDO is building upon the success of the WorldWide Antimalarial Resistance Network (WWARN), a scientifically independent, multi-disciplinary platform, founded in 2009 to provide the information necessary to prevent or alleviate antimalarial drug resistance and therefore reduce malaria morbidity and mortality.
All Publications
Building a data-sharing platform for schistosomiasis treatment data: opportunities and challenges
Jule, A., Garba, A., Guerin, P., Lang, T., & Olliaro, P. (2015). TROPICAL MEDICINE & INTERNATIONAL HEALTH, 20, 228-229.
Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis
Abdulla, S., Ashley, E., Bassat, Q., Bethell, D., Bjorkman, A., Borrmann, S., D’Alessandro, U., Dahal, P., Day, N., Diakite, M., Djimde, A., Dondorp, A., Duong, S., Edstein, Fairhurst, R., Faiz, M., Falade, C., Flegg, J., Fogg, C., … Winstanley, P. (2015). Malaria Journal, 14(1).
Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data
Abdulla, S., Adam, I., Adjei, G., Adjuik, M., Alemayehu, B., Allan, R., Arinaitwe, E., Ashley, E., Barennes, H., Barnes, K., Bassat, Q., Baudin, E., Berens-Riha, N., Bjoerkman, A., Bompart, F., Bonnet, M., Borrmann, S., Bousema, T., Brasseur, P., … Gonzalez, R. (2015). BMC Medicine, 13(1).
Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: A systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data
Ashley, E., Aweeka, F., Barnes, K., Bassat, Q., Borrmann, S., Dahal, P., Davis, T., Deloron, P., Denis, M., Djimde, A., Faucher, J., Genton, B., Guérin, P., Hamed, K., Hodel, E., Huang, L., Jullien, V., Karunajeewa, H., Kiechel, … Workman, L. (2015). BMC Medicine, 13(1).
The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data
Adjuik, M., Allan, R., Anvikar, A., Ashley, E., Barennes, H., Barnes, K., Bassat, Q., Baudin, E., Bjorkman, A., Bompart, F., Bonnet, M., Borrmann, S., Brasseur, P., Bukirwa, H., Checchi, F., Cot, M., Dahal, P., D’Alessandro, U., Deloron, P., … Ibrahim, L. (2015). BMC Medicine, 13(1).
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.
White, N., Ashley, E., Recht, J., Delves, M., Ruecker, A., Smithuis, F., Eziefula, A., Bousema, T., Drakeley, C., Chotivanich, K., Imwong, M., Pukrittayakamee, S., Prachumsri, J., Chu, C., Andolina, C., Bancone, G., Hien, T., Mayxay, M., Taylor, W., … Nosten, F. (2014). Malaria Journal, 13(1), 483.
Artemisinin resistance--modelling the potential human and economic costs
Lubell, Y., Dondorp, A., Guérin, P., Drake, T., Meek, S., Ashley, E., Day, N., White, N., & White, L. (2014). Malaria Journal, 13(1), 452.
Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
Kloprogge, F., Jullien, V., Piola, P., Dhorda, M., Muwanga, S., Nosten, F., Day, N., White, N., Guerin, P., & Tarning, J. (2014). The Journal of Antimicrobial Chemotherapy, 69(11), 3033-3040.
Spread of artemisinin resistance in Plasmodium falciparum malaria.
Ashley, E., Dhorda, M., Fairhurst, R., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J., Mao, S., Sam, B., Sopha, C., Chuor, C., Nguon, C., Sovannaroth, S., Pukrittayakamee, S., Jittamala, P., Chotivanich, K., Chutasmit, K., Suchatsoonthorn, C., … Tracking Resistance to Artemisinin Collaboration (TRAC). (2014). The New England Journal of Medicine, 371(5), 411-423.
Benefits of a pharmacology antimalarial reference standard and proficiency testing program provided by the Worldwide Antimalarial Resistance Network (WWARN).
Lourens, C., Lindegardh, N., Barnes, K., Guerin, P., Sibley, C., White, N., & Tarning, J. (2014). Antimicrobial Agents and Chemotherapy, 58(7), 3889-3894.
Mind the gaps - The epidemiology of poor-quality anti-malarials in the malarious world - Analysis of the WorldWide Antimalarial Resistance Network database
Tabernero, P., Fernández, F., Green, M., Guerin, P., & Newton, P. (2014). Malaria Journal, 13(1).
Mind the gaps--the epidemiology of poor-quality anti-malarials in the malarious world--analysis of the WorldWide Antimalarial Resistance Network database.
Tabernero, P., Fernández, F., Green, M., Guerin, P., & Newton, P. (2014). Malaria Journal, 13, 139.
Preventing the global spread of artemesinin resistance: Can we subvert evolution?
Guerin, P. (2014). International Journal of Infectious Diseases, 21, 16.
Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections.
Taylor, A., Flegg, J., Nsobya, S., Yeka, A., Kamya, M., Rosenthal, P., Dorsey, G., Sibley, C., Guerin, P., & Holmes, C. (2014). Malaria Journal, 13, 102.
International health research monitoring: Exploring a scientific and a cooperative approach using participatory action research
Chantler, T., Cheah, P., Miiro, G., Hantrakum, V., Nanvubya, A., Ayuo, E., Kivaya, E., Kidola, J., Kaleebu, P., Parker, M., Njuguna, P., Ashley, E., Guerin, P., & Lang, T. (2014). BMJ Open.
Pharmacovigilance for single low-dose primaquine: a practical approach
Poirot, E., Stergachis, A., ter Kuile, F., Guerin, P., Chen, I., & Gosling, R. (2014). Malaria Journal, 13(Suppl 1), P72 - P72.
The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
Achan, J., Adam, I., Arinaitwe, E., Ashley, E., Awab, G., Barnes, K., Bassat, Q., Borrmann, S., Bousema, T., Dahal, P., D’Alessandro, U., Davis, T., Dondorp, A., Dorsey, G., Drakeley, C., Fanello, C., Faye, B., Flegg, J., Gaye, O., … Phyo, A. (2013). PLOS MEDICINE, 10(12), 1-17.
Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives
Flegg, J., Guérin, P., Nosten, F., Ashley, E., Phyo, A., Dondorp, A., Fairhurst, R., Socheat, D., Borrmann, S., Björkman, A., Mårtensson, A., Mayxay, M., Newton, P., Bethell, D., Se, Y., Noedl, H., Diakite, M., Djimde, A., Hien, T., … Stepniewska, K. (2013). Malaria Journal, 12.
Population Pharmacokinetics of Lumefantrine in Pregnant and Nonpregnant Women With Uncomplicated Plasmodium falciparum Malaria in Uganda.
Kloprogge, F., Piola, P., Dhorda, M., Muwanga, S., Turyakira, E., Apinan, S., Lindegårdh, N., Nosten, F., Day, N., White, N., Guerin, P., & Tarning, J. (2013). CPT Pharmacometrics Syst Pharmacol, 2(11), e83.
Trends in antimalarial drug use in Africa.
Flegg, J., Metcalf, C., Gharbi, M., Venkatesan, M., Shewchuk, T., Hopkins Sibley, C., & Guerin, P. (2013). Am J Trop Med Hyg, 89(5), 857-865.
Surveillance of travellers: an additional tool for tracking antimalarial drug resistance in endemic countries
Gharbi, M., Flegg, J., Pradines, B., Berenger, A., Ndiaye, M., Djimdé, A., Roper, C., Hubert, V., Kendjo, E., Venkatesan, M., Brasseur, P., Gaye, O., Offianan, A., Penali, L., Le Bras, J., & Guérin, P. (2013). PLoS ONE, 8(10), ARTN e77775.
Pharmacokinetic properties of artemether, dihydroartemisinin, lumefantrine, and quinine in pregnant women with uncomplicated plasmodium falciparum malaria in Uganda.
Tarning, J., Kloprogge, F., Dhorda, M., Jullien, V., Nosten, F., White, N., Guerin, P., & Piola, P. (2013). Antimicrob Agents Chemother, 57(10), 5096-5103.
Infections in children admitted with complicated severe acute malnutrition in Niger
Page, A., De Rekeneire, N., Sayadi, S., Aberrane, S., Janssens, A., Rieux, C., Djibo, A., Manuguerra, J., Ducou-Le-Pointe, H., Grais, R., Schaefer, M., Guerin, P., & Baron, E. (2013). PLoS ONE, 8(7), ARTN e68699.
High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.
Woodrow, C., Dahlström, S., Cooksey, R., Flegg, J., Le Nagard, H., Mentré, F., Murillo, C., Ménard, D., Nosten, F., Sriprawat, K., Musset, L., Quashie, N., Lim, P., Fairhurst, R., Nsobya, S., Sinou, V., Noedl, H., Pradines, B., Johnson, J., … Le Bras, J. (2013). Antimicrobial Agents and Chemotherapy, 57(7), 3121-3130.
The Deinococcus radiodurans DR1245 protein, a DdrB partner homologous to YbjN proteins and reminiscent of type III secretion system chaperones.
Norais, C., Servant, P., Bouthier-de-la-Tour, C., Coureux, P.-D., Ithurbide, S., Vannier, F., Guerin, P., Dulberger, C., Satyshur, K., Keck, J., Armengaud, J., Cox, M., & Sommer, S. (2013). PloS One, 8(2), e56558.