Professor
Philippe
Guérin
Membre - Comité de pilotage sur le virus Ebola (Ebola SC)
L'Université d’Oxford
Après avoir travaillé comme médecin en France et au Népal, Philippe a rejoint Médecins Sans Frontières où il a acquis une vaste expérience en tant que chercheur travaillant sur le terrain et sur le paludisme et la tuberculose. Il a été pendant six ans directeur scientifique d'Epicentre à Paris, un centre collaborateur de l'Organisation mondiale de la santé pour la recherche en épidémiologie et la réponse aux maladies émergentes. Auparavant, il a été conseiller principal à l'Institut norvégien de santé publique pendant trois ans.
Philippe est directeur de l'Observatoire de données sur les maladies infectieuses (IDDO), dont la mission est de rassembler et d'agréger des données cliniques, laboratoire et épidémiologiques sur certaines maladies sélectionnées liées à la pauvreté et sur les infections émergentes. IDDO s’appuie sur le succès du réseau WWARN (WorldWide Antimalarial Resistance Network), une plateforme scientifiquement indépendante et multidisciplinaire, créée en 2009 pour fournir les informations nécessaires pour empêcher ou alléger la résistance aux médicaments antipaludiques et de cette manière réduire la mortalité, et la morbidité du paludisme.
All Publications
Building a data-sharing platform for schistosomiasis treatment data: opportunities and challenges
Jule, A., Garba, A., Guerin, P., Lang, T., & Olliaro, P. (2015). TROPICAL MEDICINE & INTERNATIONAL HEALTH, 20, 228-229.
Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data
Abdulla, S., Adam, I., Adjei, G., Adjuik, M., Alemayehu, B., Allan, R., Arinaitwe, E., Ashley, E., Barennes, H., Barnes, K., Bassat, Q., Baudin, E., Berens-Riha, N., Bjoerkman, A., Bompart, F., Bonnet, M., Borrmann, S., Bousema, T., Brasseur, P., … Gonzalez, R. (2015). BMC Medicine, 13(1).
Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: A systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data
Ashley, E., Aweeka, F., Barnes, K., Bassat, Q., Borrmann, S., Dahal, P., Davis, T., Deloron, P., Denis, M., Djimde, A., Faucher, J., Genton, B., Guérin, P., Hamed, K., Hodel, E., Huang, L., Jullien, V., Karunajeewa, H., Kiechel, … Workman, L. (2015). BMC Medicine, 13(1).
Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis
Abdulla, S., Ashley, E., Bassat, Q., Bethell, D., Bjorkman, A., Borrmann, S., D’Alessandro, U., Dahal, P., Day, N., Diakite, M., Djimde, A., Dondorp, A., Duong, S., Edstein, Fairhurst, R., Faiz, M., Falade, C., Flegg, J., Fogg, C., … Winstanley, P. (2015). Malaria Journal, 14(1).
The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data
Adjuik, M., Allan, R., Anvikar, A., Ashley, E., Barennes, H., Barnes, K., Bassat, Q., Baudin, E., Bjorkman, A., Bompart, F., Bonnet, M., Borrmann, S., Brasseur, P., Bukirwa, H., Checchi, F., Cot, M., Dahal, P., D’Alessandro, U., Deloron, P., … Ibrahim, L. (2015). BMC Medicine, 13(1).
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.
White, N., Ashley, E., Recht, J., Delves, M., Ruecker, A., Smithuis, F., Eziefula, A., Bousema, T., Drakeley, C., Chotivanich, K., Imwong, M., Pukrittayakamee, S., Prachumsri, J., Chu, C., Andolina, C., Bancone, G., Hien, T., Mayxay, M., Taylor, W., … Nosten, F. (2014). Malaria Journal, 13(1), 483.
Artemisinin resistance--modelling the potential human and economic costs
Lubell, Y., Dondorp, A., Guérin, P., Drake, T., Meek, S., Ashley, E., Day, N., White, N., & White, L. (2014). Malaria Journal, 13(1), 452.
Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
Kloprogge, F., Jullien, V., Piola, P., Dhorda, M., Muwanga, S., Nosten, F., Day, N., White, N., Guerin, P., & Tarning, J. (2014). The Journal of Antimicrobial Chemotherapy, 69(11), 3033-3040.
Spread of artemisinin resistance in Plasmodium falciparum malaria.
Ashley, E., Dhorda, M., Fairhurst, R., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J., Mao, S., Sam, B., Sopha, C., Chuor, C., Nguon, C., Sovannaroth, S., Pukrittayakamee, S., Jittamala, P., Chotivanich, K., Chutasmit, K., Suchatsoonthorn, C., … Tracking Resistance to Artemisinin Collaboration (TRAC). (2014). The New England Journal of Medicine, 371(5), 411-423.
Benefits of a pharmacology antimalarial reference standard and proficiency testing program provided by the Worldwide Antimalarial Resistance Network (WWARN).
Lourens, C., Lindegardh, N., Barnes, K., Guerin, P., Sibley, C., White, N., & Tarning, J. (2014). Antimicrobial Agents and Chemotherapy, 58(7), 3889-3894.
Mind the gaps - The epidemiology of poor-quality anti-malarials in the malarious world - Analysis of the WorldWide Antimalarial Resistance Network database
Tabernero, P., Fernández, F., Green, M., Guerin, P., & Newton, P. (2014). Malaria Journal, 13(1).
Mind the gaps--the epidemiology of poor-quality anti-malarials in the malarious world--analysis of the WorldWide Antimalarial Resistance Network database.
Tabernero, P., Fernández, F., Green, M., Guerin, P., & Newton, P. (2014). Malaria Journal, 13, 139.
Preventing the global spread of artemesinin resistance: Can we subvert evolution?
Guerin, P. (2014). International Journal of Infectious Diseases, 21, 16.
Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections.
Taylor, A., Flegg, J., Nsobya, S., Yeka, A., Kamya, M., Rosenthal, P., Dorsey, G., Sibley, C., Guerin, P., & Holmes, C. (2014). Malaria Journal, 13, 102.
International health research monitoring: Exploring a scientific and a cooperative approach using participatory action research
Chantler, T., Cheah, P., Miiro, G., Hantrakum, V., Nanvubya, A., Ayuo, E., Kivaya, E., Kidola, J., Kaleebu, P., Parker, M., Njuguna, P., Ashley, E., Guerin, P., & Lang, T. (2014). BMJ Open.
Pharmacovigilance for single low-dose primaquine: a practical approach
Poirot, E., Stergachis, A., ter Kuile, F., Guerin, P., Chen, I., & Gosling, R. (2014). Malaria Journal, 13(Suppl 1), P72 - P72.
The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
Achan, J., Adam, I., Arinaitwe, E., Ashley, E., Awab, G., Barnes, K., Bassat, Q., Borrmann, S., Bousema, T., Dahal, P., D’Alessandro, U., Davis, T., Dondorp, A., Dorsey, G., Drakeley, C., Fanello, C., Faye, B., Flegg, J., Gaye, O., … Phyo, A. (2013). PLOS MEDICINE, 10(12), 1-17.
Population Pharmacokinetics of Lumefantrine in Pregnant and Nonpregnant Women With Uncomplicated Plasmodium falciparum Malaria in Uganda.
Kloprogge, F., Piola, P., Dhorda, M., Muwanga, S., Turyakira, E., Apinan, S., Lindegårdh, N., Nosten, F., Day, N., White, N., Guerin, P., & Tarning, J. (2013). CPT Pharmacometrics Syst Pharmacol, 2(11), e83.
Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives
Flegg, J., Guérin, P., Nosten, F., Ashley, E., Phyo, A., Dondorp, A., Fairhurst, R., Socheat, D., Borrmann, S., Björkman, A., Mårtensson, A., Mayxay, M., Newton, P., Bethell, D., Se, Y., Noedl, H., Diakite, M., Djimde, A., Hien, T., … Stepniewska, K. (2013). Malaria Journal, 12.
Trends in antimalarial drug use in Africa.
Flegg, J., Metcalf, C., Gharbi, M., Venkatesan, M., Shewchuk, T., Hopkins Sibley, C., & Guerin, P. (2013). Am J Trop Med Hyg, 89(5), 857-865.
Surveillance of travellers: an additional tool for tracking antimalarial drug resistance in endemic countries
Gharbi, M., Flegg, J., Pradines, B., Berenger, A., Ndiaye, M., Djimdé, A., Roper, C., Hubert, V., Kendjo, E., Venkatesan, M., Brasseur, P., Gaye, O., Offianan, A., Penali, L., Le Bras, J., & Guérin, P. (2013). PLoS ONE, 8(10), ARTN e77775.
Pharmacokinetic properties of artemether, dihydroartemisinin, lumefantrine, and quinine in pregnant women with uncomplicated plasmodium falciparum malaria in Uganda.
Tarning, J., Kloprogge, F., Dhorda, M., Jullien, V., Nosten, F., White, N., Guerin, P., & Piola, P. (2013). Antimicrob Agents Chemother, 57(10), 5096-5103.
Infections in children admitted with complicated severe acute malnutrition in Niger
Page, A., De Rekeneire, N., Sayadi, S., Aberrane, S., Janssens, A., Rieux, C., Djibo, A., Manuguerra, J., Ducou-Le-Pointe, H., Grais, R., Schaefer, M., Guerin, P., & Baron, E. (2013). PLoS ONE, 8(7), ARTN e68699.
High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.
Woodrow, C., Dahlström, S., Cooksey, R., Flegg, J., Le Nagard, H., Mentré, F., Murillo, C., Ménard, D., Nosten, F., Sriprawat, K., Musset, L., Quashie, N., Lim, P., Fairhurst, R., Nsobya, S., Sinou, V., Noedl, H., Pradines, B., Johnson, J., … Le Bras, J. (2013). Antimicrobial Agents and Chemotherapy, 57(7), 3121-3130.
The Deinococcus radiodurans DR1245 protein, a DdrB partner homologous to YbjN proteins and reminiscent of type III secretion system chaperones.
Norais, C., Servant, P., Bouthier-de-la-Tour, C., Coureux, P.-D., Ithurbide, S., Vannier, F., Guerin, P., Dulberger, C., Satyshur, K., Keck, J., Armengaud, J., Cox, M., & Sommer, S. (2013). PloS One, 8(2), e56558.