Category
Dr
Mehul
Dhorda
Co-Lead Head of Antimalarial Resistance Theme
Head of Africa Asia Programme
Mahidol-Oxford Tropical Medicine Research Unit
Email
Research Theme
Malaria
WWARN
Dr Mehul Dhorda joined the WorldWide Antimalarial Research Network (WWARN) - now part of the IDDO network - in 2011 as a laboratory scientist and was Head of WWARN External Quality Assurance Programme, leading the laboratory activities for the WWARN Tracking Resistance to Artemisinin Collaboration Activities. He has extensive experience in molecular biology and also in clinical trials for tropical diseases in both Africa and Asia from his time spent working with Médecins Sans Frontières, Epicentre and University of Maryland School of Medicine. He serves as a member of WHO organised committees for quality assurance in malaria parasite detection and quantification. Mehul completed an MSc at Rutgers University, NJ, USA and holds a PhD in Molecular Parasitology from the Université Pierre et Marie Curie in France.
All Publications
Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
Kloprogge, F., Jullien, V., Piola, P., Dhorda, M., Muwanga, S., Nosten, F., Day, N., White, N., Guerin, P., & Tarning, J. (2014). The Journal of Antimicrobial Chemotherapy, 69(11), 3033-3040.
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.
Venkatesan, M., Gadalla, N., Stepniewska, K., Dahal, P., Nsanzabana, C., Moriera, C., Price, R., Mårtensson, A., Rosenthal, P., Dorsey, G., Sutherland, C., Guérin, P., Davis, T., Ménard, D., Adam, I., Ademowo, G., Arze, C., Baliraine, F., Berens-Riha, N., … Ogutu, B. (2014). American Journal of Tropical Medicine and Hygiene, 91(4), 833-843.
Spread of artemisinin resistance in Plasmodium falciparum malaria.
Ashley, E., Dhorda, M., Fairhurst, R., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J., Mao, S., Sam, B., Sopha, C., Chuor, C., Nguon, C., Sovannaroth, S., Pukrittayakamee, S., Jittamala, P., Chotivanich, K., Chutasmit, K., Suchatsoonthorn, C., … Tracking Resistance to Artemisinin Collaboration (TRAC). (2014). The New England Journal of Medicine, 371(5), 411-423.
Population Pharmacokinetics of Lumefantrine in Pregnant and Nonpregnant Women With Uncomplicated Plasmodium falciparum Malaria in Uganda.
Kloprogge, F., Piola, P., Dhorda, M., Muwanga, S., Turyakira, E., Apinan, S., Lindegårdh, N., Nosten, F., Day, N., White, N., Guerin, P., & Tarning, J. (2013). CPT Pharmacometrics Syst Pharmacol, 2(11), e83.
Pharmacokinetic properties of artemether, dihydroartemisinin, lumefantrine, and quinine in pregnant women with uncomplicated plasmodium falciparum malaria in Uganda.
Tarning, J., Kloprogge, F., Dhorda, M., Jullien, V., Nosten, F., White, N., Guerin, P., & Piola, P. (2013). Antimicrob Agents Chemother, 57(10), 5096-5103.
Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority trial.
Schramm, B., Valeh, P., Baudin, E., Mazinda, C., Smith, R., Pinoges, L., Dhorda, M., Boum, Y., Sundaygar, T., Zolia, Y., Jones, J., Comte, E., Houzé, P., Jullien, V., Carn, G., Ashley, E., & Guérin, P. (2013). Malar J, 12(1).
Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
Tarning, J., Kloprogge, F., Piola, P., Dhorda, M., Muwanga, S., Turyakira, E., Nuengchamnong, N., Nosten, F., Day, N., White, N., Guerin, P., & Lindegardh, N. (2012). Malar J, 11(1).
Performance of a histidine-rich protein 2 rapid diagnostic test, Paracheck Pf®, for detection of malaria infections in Ugandan pregnant women
Dhorda, M., Piola, P., Nyehangane, D., Tumwebaze, B., Nalusaji, A., Nabasumba, C., Turyakira, E., McGready, R., Ashley, E., Guerin, P., & Snounou, G. (2012). American Journal of Tropical Medicine and Hygiene, 86(1), 93-95.
Efficacy of fixed-dose combination artesunate-amodiaquine versus artemether-lumefantrine for uncomplicated childhood Plasmodium falciparum malaria in Democratic Republic of Congo: a randomized non-inferiority trial.
Espié, E., Lima, A., Atua, B., Dhorda, M., Flévaud, L., Sompwe, E., Palma Urrutia, P., & Guerin, P. (2012). Malaria Journal, 11(1).
Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial.
Muehlenbachs, A., Nabasumba, C., McGready, R., Turyakira, E., Tumwebaze, B., Dhorda, M., Nyehangane, D., Nalusaji, A., Nosten, F., Guerin, P., & Piola, P. (2012). Malaria Journal, 1.
Transmission of Plasmodium vivax in south-western Uganda: report of three cases in pregnant women.
Dhorda, M., Nyehangane, D., Renia, L., Piola, P., Guerin, P., & Snounou, G. (2011). PloS One, 6(5).
Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial.
Piola, P., Nabasumba, C., Turyakira, E., Dhorda, M., Lindegardh, N., Nyehangane, D., Snounou, G., Ashley, E., McGready, R., Nosten, F., & Guerin, P. (2010). Lancet Infect Dis, 10(11), 762-769.
EFFICACY AND SAFETY OF QUININE VS. ARTEMETHER-LUMEFANTRINE IN UNCOMPLICATED MALARIA DURING PREGNANCY, MBARARA, UGANDA
Piola, P., Nabasumba, C., Turyakira, E., Dhorda, M., Fogg, C., Snounou, G., Ashley, E., Barnes, K., McGready, R., Nosten, F., & Guerin, P. (2009). AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 81(5), 8-8.
Prevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method.
Gerstl, S., Kiwila, G., Dhorda, M., Lonlas, S., Myatt, M., Ilunga, B., Lemasson, D., Szumilin, E., Guerin, P., & Ferradini, L. (2009). PloS One, 4(7).
Yaws outbreak in the Democratic Republic of Congo: The return of a forgotten disease
Gerstl, S., Ferradini, L., Kiwila, G., Dhorda, M., Lonlas, S., N’Danu, T., Lemasson, D., Szumilin, E., & Guerin, P. (2005). AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 73(6), 14-14.
Adaptive Geospatial Surveillance System for Antimalarial Drug Resistance
Gupta, A., Harrison, L., Nain, M., Singh-Phulgenda, S., Chhajed, R., kumar, R., Das, A., Rahi, M., Guerin, P., Anvikar, A., Dhorda, M., Flegg, J., & Bharti, P. (n.d.). In medRxiv.