Category
Dr
James
Watson
Associate Director
Co-Lead Malaria Chemoprevention Theme
Email
Research Theme
Malaria
Chagas
WWARN
James Watson joined IDDO in March 2023 as Associate Director.
He is a Sir Henry Dale Fellow funded by the Wellcome Trust working on improving the diagnosis and treatment of severe falciparum malaria.
James is a statistician by training and previously worked at the Mahidol Oxford Tropical Medicine Research Unit in Bangkok for seven years before moving to the Oxford University Clinical Research Unit in Viet Nam.
His research interests also include the radical cure of Plasmodium vivax malaria, SARS-CoV-2 antivirals, Chagas disease, snakebite and adaptive trial design.
All Publications
Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open-label, randomised, controlled, adaptive platform trial
Luvira, V., Schilling, W., Jittamala, P., Watson, J., Boyd, S., Siripoon, T., Ngamprasertchai, T., Almeida, P., Ekkapongpisit, M., Cruz, C., Callery, J., Singh, S., Tuntipaiboontana, R., Kruabkontho, V., Ngernseng, T., Tubprasert, J., Abdad, M., Keayarsa, S., Madmanee, W., … White, N. (2024). BMC Infectious Disease, 24(1).
Modelling the within-host dynamics ofPlasmodium vivaxhypnozoite activation: an analysis of the SPf66 vaccine trial
Mehra, S., Nosten, F., Luxemburger, C., White, N., & Watson, J. (2024). In medRxiv.
Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV)
Wongnak, P., Schilling, W., Jittamala, P., Boyd, S., Luvira, V., Siripoon, T., Ngamprasertchai, T., Batty, E., Singh, S., Kouhathong, J., Pagornrat, W., Khanthagan, P., Hanboonkunupakarn, B., Poovorawan, K., Mayxay, M., Chotivanich, K., Imwong, M., Pukrittayakamee, S., Ashley, E., … Watson, J. (2024). In medRxiv.
Methaemoglobin as a surrogate marker of primaquine antihypnozoite activity inPlasmodium vivaxmalaria: a systematic review and individual patient data meta-analysis
Fadilah, I., Commons, R., Chau, N., Chu, C., Day, N., Koh, G., Green, J., Lacerda, M., Llanos-Cuentas, A., Nelwan, E., Nosten, F., Pasaribu, A., Sutanto, I., Taylor, W., Thriemer, K., Price, R., White, N., Baird, K., & Watson, J. (2024). In medRxiv.
Transmission-blocking activity of artesunate, chloroquine and methylene blue onPlasmodium vivaxgametocytes
Chaumeau, V., Wasisakun, P., Watson, J., Oo, T., Aryalamloed, S., Sue, M., Htoo, G., Tha, N., Archusuksan, L., Sawasdichai, S., Gornsawun, G., Mehra, S., White, N., & Nosten, F. (2024). In bioRxiv.
Within-host modelling of primaquine-induced haemolysis in hemizygote glucose-6-phosphate dehydrogenase deficient healthy volunteers
Watson, J., Mehdipour, P., Moss, R., Jittamala, P., Zaloumis, S., Price, D., Dini, S., Hanboonkunupakarn, B., Leungsinsiri, P., Poovorawan, K., Chotivanich, K., Bancone, G., Commons, R., Day, N., Pukrittayakamee, S., Taylor, W., White, N., & Simpson, J. (2024). In medRxiv.
Phase 2 pilot trial to optimise pharmacometric evaluations in Chagas disease (CHARM: CHAgas disease PharMacometrics)
Cruz, C., Watson, J., Molina Romero, I., & White, N. (2024).
Quantifying anti-trypanosomal treatment effects in chronic indeterminate Chagas disease: an individual patient data meta-analysis of two proof of concept trials
Watson, J., Cruz, C., Barreira, F., Forsyth, C., Schijman, A., Peploe, R., Assmus, F., Naylor, C., Lee, J., Mehra, S., Tarning, J., Torrico, F., Gascon, J., Ortiz, L., Ribeiro, I., Sosa-Estani, S., Tipple, C., Hugonnet, S., Guérin, P., … White, N. (2024). In medRxiv.
Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)
Jittamala, P., Boyd, S., Schilling, W., Watson, J., Ngamprasertchai, T., Siripoon, T., Luvira, V., Batty, E., Wongnak, P., Esper, L., Almeida, P., Cruz, C., Ascencao, F., Aguiar, R., Ghanchi, N., Callery, J., Singh, S., Kruabkontho, V., Ngernseng, T., … White, N. (2024). In medRxiv.
Rectal artesunate suppositories for the pre-referral treatment of suspected severe malaria
Watson, J., Peto, T., & White, N. (2023). PLoS Medicine, 20(11).
Antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial
Schilling, W., Jittamala, P., Watson, J., Boyd, S., Luvira, V., Siripoon, T., Ngamprasertchai, T., Batty, E., Cruz, C., Callery, J., Singh, S., Saroj, M., Kruabkontho, V., Ngernseng, T., Tanglakmankhong, N., Tubprasert, J., Abdad, M., Madmanee, W., Kouhathong, J., … White, N. (2023). Lancet Infectious Diseases, 24(1), 36-45.
Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis
Commons, R., Rajasekhar, M., Edler, P., Abreha, T., Awab, G., Baird, J., Barber, B., Chu, C., Cui, L., Daher, A., Gonzalez-Ceron, L., Grigg, M., Hwang, J., Karunajeewa, H., Lacerda, M., Ladeia-Andrade, S., Lidia, K., Llanos-Cuentas, A., Longley, R., … Price, R. (2023). Lancet Infectious Diseases, 24(2), 172-183.
Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis
Rajasekhar, M., Simpson, J., Ley, B., Edler, P., Chu, C., Abreha, T., Awab, G., Baird, J., Bancone, G., Barber, B., Grigg, M., Hwang, J., Karunajeewa, H., Lacerda, M., Ladeia-Andrade, S., Llanos-Cuentas, A., Pukrittayakamee, S., Rijal, K., Saravu, K., … Price, R. (2023). Lancet Infectious Diseases, 24(2), 184-195.
Evidence based optimal dosing of intravenous artesunate in children with severe falciparum malaria
Haghiri, A., Price, D., Fitzpatrick, P., Dini, S., Rajasekhar, M., Fanello, C., Tarning, J., Watson, J., White, N., & Simpson, J. (2023). Clinical Pharmacology and Therapeutics.
Définition d’un jeu universel de critères de décision de base pour les essais cliniques sur les morsures de serpent: traduction par Jean-Philippe Chippaux de l’article de Abouyannis M, et al. A global core outcome measurement set for snakebite clinical trials
Abouyannis, M., Esmail, H., Hamaluba, M., Ngama, M., Mwangudzah, H., Mumba, N., Yeri, B., Mwalukore, S., Alphan, H., Aggarwal, D., Alcoba, G., Cammack, N., Chippaux, J.-P., Coldiron, M., Gutiérrez, J., Habib, A., Harrison, R., Isbister, G., Lavonas, E., … Lalloo, D. (2023). Médecine Tropicale et Santé Internationale, 3(3).
Clinical antiviral efficacy of remdesivir in coronavirus disease 2019: an open-label, randomized controlled adaptive platform trial (PLATCOV)
Jittamala, P., Schilling, W., Watson, J., Luvira, V., Siripoon, T., Ngamprasertchai, T., Almeida, P., Ekkapongpisit, M., Cruz, C., Callery, J., Boyd, S., Anunsittichai, O., Hongsuwan, M., Singhaboot, Y., Pagornrat, W., Tuntipaiboontana, R., Kruabkontho, V., Ngernseng, T., Tubprasert, J., … White, N. (2023). The Journal of Infectious Diseases, 228(10), 1318-1325.
The CARAMAL study could not assess the effectiveness of rectal artesunate in treating suspected severe malaria
Watson, J., Peto, T., & White, N. (2023). BMC Medicine, 21(1).
Which trial do we need? A global, adaptive, platform trial to reduce death and disability from tuberculous meningitis.
Thwaites, G., Watson, J., Thuong Thuong, N., Huynh, J., Walker, T., & Phu, N. (2023). Clinical Microbiology and Infection : The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 29(7), 826-828.
Which trial do we need? A global, adaptive, platform trial to reduce death and disability from tuberculous meningitis
Thwaites, G., Watson, J., Thuong, N., Huynh, J., Walker, T., & Phu, N. (2023). Clinical Microbiology and Infection, 29(7), 826-828.
Lineage-informative microhaplotypes for spatio-temporal surveillance of Plasmodium vivax malaria parasites.
Siegel, S., Amato, R., Trimarsanto, H., Sutanto, E., Kleinecke, M., Murie, K., Whitton, G., Taylor, A., Watson, J., Imwong, M., Assefa, A., Rahim, A., Chau, N., Hien, T., Green, J., Koh, G., White, N., Day, N., Kwiatkowski, D., … Auburn, S. (2023). MedRxiv, 4(03-29), 2023.03.13.23287179.
Pharmacometrics of high dose ivermectin in early COVID-19: an open label, randomized, controlled adaptive platform trial (PLATCOV)
Schilling, W., Jittamala, P., Watson, J., Ekkapongpisit, M., Siripoon, T., Ngamprasertchai, T., Luvira, V., Pongwilai, S., Cruz, C., Callery, J., Boyd, S., Kruabkontho, V., Ngernseng, T., Tubprasert, J., Abdad, M., Piaraksa, N., Suwannasin, K., Hanboonkunupakarn, P., Hanboonkunupakarn, B., … White, N. (2023). ELife, 12.
WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria
Peto, T., Watson, J., White, N., & Dondorp, A. (2023). Transactions of The Royal Society of Tropical Medicine and Hygiene, 117(7), 536-538.
A global core outcome measurement set for snakebite clinical trials
Abouyannis, M., Esmail, H., Hamaluba, M., Ngama, M., Mwangudzah, H., Mumba, N., Yeri, B., Mwalukore, S., Alphan, H., Aggarwal, D., Alcoba, G., Cammack, N., Chippaux, J.-P., Coldiron, M., Gutierrez, J., Habib, A., Harrison, R., Ibister, G., Lavonas, E., … Lalloo, D. (2023). Lancet Global Health, 11(2), E296 - E300.
Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open- label, randomised, controlled adaptive platform trial
Luvira, V., Schilling, W., Jittamala, P., Watson, J., Boyd, S., Siripoon, T., Ngamprasertchai, T., Almeida, P., Ekkapongpisit, M., Cruz, C., Callery, J., Singh, S., Tuntipaiboontana, R., Kruabkontho, V., Ngernseng, T., Tubprasert, J., Abdad, M., Keayarsa, S., Madmanee, W., … White, N. (2023). In Research Square.
Pharmacometric assessment of primaquine induced haemolysis in glucose-6-phosphate dehydrogenase deficiency
Pukrittayakamee, S., Jittamala, P., Watson, J., Hanboonkunupakarn, B., Leungsinsiri, P., Poovorawan, K., Chotivanich, K., Bancone, G., Chu, C., Imwong, M., Day, N., Taylor, W., & White, N. (2023). In medRxiv.