Category
Dr
Mehul
Dhorda
Co-Lead Head of Antimalarial Resistance Theme
Head of Africa Asia Programme
Mahidol-Oxford Tropical Medicine Research Unit
Email
Research Theme
Malaria
WWARN
Dr Mehul Dhorda joined the WorldWide Antimalarial Research Network (WWARN) - now part of the IDDO network - in 2011 as a laboratory scientist and was Head of WWARN External Quality Assurance Programme, leading the laboratory activities for the WWARN Tracking Resistance to Artemisinin Collaboration Activities. He has extensive experience in molecular biology and also in clinical trials for tropical diseases in both Africa and Asia from his time spent working with Médecins Sans Frontières, Epicentre and University of Maryland School of Medicine. He serves as a member of WHO organised committees for quality assurance in malaria parasite detection and quantification. Mehul completed an MSc at Rutgers University, NJ, USA and holds a PhD in Molecular Parasitology from the Université Pierre et Marie Curie in France.
Key Publications
Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis
Ashley, E., Dhorda, M., Dondorp, A., Fanello, C., Guérin, P., Humphreys, G., Kennon, K., Mayxay, M., Nosten, F., Phyo, A., Sibley, C., Sondo, P., Stepniewska, K., White, N., & Woodrow, C. (2019). BMC Medicine, 1(17).
Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia
Grist, E., Flegg, J., Humphreys, G., Mas, I., Ashley, E., Humphreys, G., Dhorda, M., Dondorp, A., Hien, T., Maude, R., Mayxay, M., Nosten, F., Newton, P., Price, R., Smithuis, F., White, N., Woodrow, C., Guerin, P., & Gething, P. (2016). International Journal of Health Geographics, 15(37), 1-10.
Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker
Tun, K., Imwong, M., Lwin, K., Win, A., Hlaing, T., Hlaing, T., Lin, K., Kyaw, M., Plewes, K., Faiz, M., Dhorda, M., Cheah, P., Pukrittayakamee, S., Ashley, E., Anderson, T., Nair, S., McDew-White, M., Flegg, J., Grist, E., … Woodrow, C. (2015). The Lancet Infectious Diseases, 15(4), 415-421.
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.
Venkatesan, M., Gadalla, N., Stepniewska, K., Dahal, P., Nsanzabana, C., Moriera, C., Price, R., Mårtensson, A., Rosenthal, P., Dorsey, G., Sutherland, C., Guérin, P., Davis, T., Ménard, D., Adam, I., Ademowo, G., Arze, C., Baliraine, F., Berens-Riha, N., … Ogutu, B. (2014). American Journal of Tropical Medicine and Hygiene, 91(4), 833-843.
Spread of artemisinin resistance in Plasmodium falciparum malaria.
Ashley, E., Dhorda, M., Fairhurst, R., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J., Mao, S., Sam, B., Sopha, C., Chuor, C., Nguon, C., Sovannaroth, S., Pukrittayakamee, S., Jittamala, P., Chotivanich, K., Chutasmit, K., Suchatsoonthorn, C., … Tracking Resistance to Artemisinin Collaboration (TRAC). (2014). The New England Journal of Medicine, 371(5), 411-423.
Spread of artemisinin resistance in Plasmodium falciparum malaria.
Ashley, E., Dhorda, M., Fairhurst, R., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J., Mao, S., Sam, B., Sopha, C., Chuor, C., Nguon, C., Sovannaroth, S., Pukrittayakamee, S., Jittamala, P., Chotivanich, K., Chutasmit, K., Suchatsoonthorn, C., … Tracking Resistance to Artemisinin Collaboration (TRAC). (2014). The New England Journal of Medicine, 371(5), 411-423.
Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority trial.
Schramm, B., Valeh, P., Baudin, E., Mazinda, C., Smith, R., Pinoges, L., Dhorda, M., Boum, Y., Sundaygar, T., Zolia, Y., Jones, J., Comte, E., Houzé, P., Jullien, V., Carn, G., Ashley, E., & Guérin, P. (2013). Malar J, 12(1).
All Publications
Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial
Schilling, W., Mukaka, M., Callery, J., Llewelyn, M., Cruz, C., Dhorda, M., Ngernseng, T., Waithira, N., Ekkapongpisit, M., Watson, J., Chandna, A., Nelwan, E., Hamers, R., Etyang, A., Beg, M., Sow, S., Yavo, W., Allabi, A., Basnyat, B., … Tarning, J. (2024). PLoS Medicine, 21(9).
Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning
Das, D., Vongpromek, R., Assawariyathipat, T., Srinamon, K., Kennon, K., Stepniewska, K., Ghose, A., Sayeed, A., Faiz, M., Netto, R., Siqueira, A., Yerbanga, S., Ouédraogo, J., Callery, J., Peto, T., Tripura, R., Koukouikila-Koussounda, F., Ntoumi, F., Ong’echa, J., … Dhorda, M. (2022). Malaria Journal, 21.
Molecular surveillance for operationally relevant genetic polymorphisms in Plasmodium falciparum in Southern Chad, 2016–2017
Das, S., Kérah-Hinzoumbé, C., Kebféné, M., Srisutham, S., Nagorngar, T.-Y., Saralamba, N., Vongpromek, R., Khomvarn, T., Sibley, C., Guérin, P., Imwong, M., & Dhorda, M. (2022). Malaria Journal, 21(1).
Boosting the impact of seasonal malaria chemoprevention (SMC) through simultaneous screening and treatment of household members of children receiving SMC in Burkina Faso: a protocol for a randomized open label trial.
Sondo, P., Tahita, M., Ilboudo, H., Rouamba, T., Derra, K., Tougri, G., Ouédraogo, F., Konseibo, B., Roamba, E., Otienoburu, S., Kaboré, B., Kennon, K., Ouédraogo, K., Zongo, W.-T.-N., Bocoum, F., Stepniewska, K., Dhorda, M., Guérin, P., & Tinto, H. (2022). Archives of Public Health = Archives Belges de Sante Publique, 80(1), 41.
Evolution of multidrug resistance in Plasmodium falciparum: A longitudinal study of genetic resistance markers in the Greater Mekong subregion
Imwong, M., Suwannasin, K., Srisutham, S., Vongpromek, R., Promnarate, C., Saejeng, A., Phyo, A., Proux, S., Pongvongsa, T., Chea, N., Miotto, O., Tripura, R., Nguyen Hoang, C., Dysoley, L., Ho Dang Trung, N., Peto, T., Callery, J., van der Pluijm, R., Amaratunga, C., … Dondorp, A. (2021). Antimicrobial Agents and Chemotherapy, 65(12).
The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response
Zhu, L., Pluijm, R., Kucharski, M., Nayak, S., Tripathi, J., Nosten, F., Faiz, A., Amaratunga, C., Lek, D., Ashley, E., Smithuis, F., Phyo, A., Lin, K., Imwong, M., Mayxay, M., Dhorda, M., Chau, N., Thuy, N., Newton, P., … Bozdech, Z. (2021).
A systematic literature review of microscopy methods reported in malaria clinical trials
Das, D., Dahal, P., Dhorda, M., Citarella, B., Kennon, K., Stepniewska, K., Felger, I., Chappuis, F., & Guerin, P. (2020). American Journal of Tropical Medicine and Hygiene, 104(3), 836-841.
Chloroquine/ hydroxychloroquine prevention of coronavirus disease (COVID-19) in the healthcare setting; protocol for a randomised, placebo-controlled prophylaxis study (COPCOV)
Schilling, W., Callery, J., Taylor, W., Mukaka, M., Ekkapongpisit, M., Watson, J., Chandna, A., Panapipat, S., Tubprasert, J., Yuentrakul, P., Waithira, N., Cope, T., Dhorda, M., Cruz, C., von Seidlein, L., Milton, J., LLewelyn, M., Adler, A., Chotivanich, K., … White, N. (2020). Wellcome Open Research, 5, 241-241.
Towards harmonization of microscopy methods for malaria clinical research studies
Dhorda, M., Ba, E., Kevin Baird, J., Barnwell, J., Bell, D., Carter, J., Dondorp, A., Ekawati, L., Gatton, M., González, I., Guérin, P., Incardona, S., Lilley, K., Menard, D., Nosten, F., Obare, P., Ogutu, B., Olliaro, P., Price, R., … Sokhna, C. (2020). Malaria Journal, 19(1).
Mass drug administrations with dihydroartemisinin-piperaquine and single low dose primaquine to eliminate Plasmodium falciparum have only a transient impact on Plasmodium vivax: Findings from randomised controlled trials
Phommasone, K., van Leth, F., Peto, T., Landier, J., Nguyen, T.-N., Tripura, R., Pongvongsa, T., Lwin, K., Kajeechiwa, L., Thwin, M., Parker, D., Wiladphaingern, J., Nosten, S., Proux, S., Nguon, C., Davoeung, C., Rekol, H., Adhikari, B., Promnarate, C., … von Seidlein, L. (2020). PLoS ONE, 15(2).
Correction to: The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR.
Phommasone, K., van Leth, F., Imwong, M., Henriques, G., Pongvongsa, T., Adhikari, B., Peto, T., Promnarate, C., Dhorda, M., Sirithiranont, P., Mukaka, M., Peerawaranun, P., Day, N., Cobelens, F., Dondorp, A., Newton, P., White, N., von Seidlein, L., & Mayxay, M. (2020). Malaria Journal, 19(1), 32.
Malaria control in India: a national perspective in a regional and global fight to eliminate malaria
Guerin, P., Dhorda, M., Ganguly, N., & Sibley, C. (2019). Journal of Vector Borne Diseases, 56(1), 41-45.
Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis
Ashley, E., Dhorda, M., Dondorp, A., Fanello, C., Guérin, P., Humphreys, G., Kennon, K., Mayxay, M., Nosten, F., Phyo, A., Sibley, C., Sondo, P., Stepniewska, K., White, N., & Woodrow, C. (2019). BMC Medicine, 1(17).
FIELD EVALUATION OF AUTOMATED DIGITAL MALARIA MICROSCOPY: EASYSCAN GO
Vongpromek, R., Proux, S., Ekawati, L., Archasuksan, L., Bachman, C., Bell, D., Sutanto, I., & Dhorda, M. (2019). TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 113, S14 - S15.
Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine (vol 91, pg 833, 2014)
Venkatesan, M., Gadalla, N., Stepniewska, K., Dahal, P., Nsanzabana, C., Moriera, C., Price, R., Martensson, A., Rosenthal, P., Dorsey, G., Sutherland, C., Guerin, P., Davis, T., Menard, D., Adam, I., Ademowo, G., Arze, C., Baliraine, F., Berens-Riha, N., … Ogutu, B. (2019). AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 3.
An inventory of supranational antimicrobial resistance surveillance networks involving low- and middle-income countries since 2000
Ashley, E., Recht, J., Chua, A., Dance, D., Dhorda, M., Thomas, N., Ranganathan, N., Turner, P., Guerin, P., White, N., & Day, N. (2018). Journal of Antimicrobial Chemotherapy.
Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia
Grist, E., Flegg, J., Humphreys, G., Mas, I., Ashley, E., Humphreys, G., Dhorda, M., Dondorp, A., Hien, T., Maude, R., Mayxay, M., Nosten, F., Newton, P., Price, R., Smithuis, F., White, N., Woodrow, C., Guerin, P., & Gething, P. (2016). International Journal of Health Geographics, 15(37), 1-10.
Abundance of megalin and Dab2 is reduced in syncytiotrophoblast during placental malaria, which may contribute to low birth weight
Lybbert, J., Gullingsrud, J., Chesnokov, O., Turyakira, E., Dhorda, M., Guerin, P., Piola, P., Muehlenbachs, A., & Oleinikov, A. (2016). Scientific Reports, 6, Article 24508.
Microscopy for the detection, identification and quantification of malaria parasites on stained thick and thin blood films in research settings
Dhorda, M., Guerin, P., Baird, J., Carter, J., & Olliaro, P. (2015). World Health Organization, Geneva.
Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker
Tun, K., Imwong, M., Lwin, K., Win, A., Hlaing, T., Hlaing, T., Lin, K., Kyaw, M., Plewes, K., Faiz, M., Dhorda, M., Cheah, P., Pukrittayakamee, S., Ashley, E., Anderson, T., Nair, S., McDew-White, M., Flegg, J., Grist, E., … Woodrow, C. (2015). The Lancet Infectious Diseases, 15(4), 415-421.
Genetic architecture of artemisinin-resistant Plasmodium falciparum
Miotto, O., Amato, R., Ashley, E., MacInnis, B., Almagro-Garcia, J., Amaratunga, C., Lim, P., Mead, D., Oyola, S., Dhorda, M., Imwong, M., Woodrow, C., Manske, M., Stalker, J., Drury, E., Campino, S., Amenga-Etego, L., Thanh, T.-N., Tran, H., … Kwiatkowski, D. (2015). Nature Genetics, 47(3), 226-234.
LARGE-SCALE SCANS FOR GENOMIC REGIONS UNDER POSITIVE SELECTION IN SOUTHEAST ASIAN PLASMODIUM FALCIPARUM REVEAL GENES OF PUBLIC HEALTH IMPORTANCE
Jacob, C., Arze, C., Saunders, D., Lanteri, C., Fairhurst, R., Amaratunga, C., Tan, J., Miller, B., Miotto, O., MacInnis, B., Lim, P., Suon, S., Yi, P., Sreng, S., Jittamala, P., Chotivanich, K., Imwong, M., Chutasmit, K., Suchatsoonthorn, C., … Plowe, C. (2015). AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 93(4), 560-560.
HUMORAL IMMUNITY CONTRIBUTES TO CLEARANCE OF ARTEMISININ-RESISTANT PARASITES IN SOUTHEAST ASIA
Travassos, M., Bailey, J., Takala-Harrison, S., Manwani, B., Berry, A., Pablo, J., Jasinskas, A., Nakajima, R., Adams, M., Ashley, E., Dhorda, M., Nosten, F., Phyo, A., Newton, P., Mayxay, M., Dondorp, A., Tran, T., Han, K.-T., Kway, M., … Plowe, C. (2015). AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 93(4), 289-289.
Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.
Mok, S., Ashley, E., Ferreira, P., Zhu, L., Lin, Z., Yeo, T., Chotivanich, K., Imwong, M., Pukrittayakamee, S., Dhorda, M., Nguon, C., Lim, P., Amaratunga, C., Suon, S., Hien, T., Htut, Y., Faiz, M., Onyamboko, M., Mayxay, M., … Bozdech, Z. (2015). Science (New York, N.Y.), 347(6220), 431-435.
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.
White, N., Ashley, E., Recht, J., Delves, M., Ruecker, A., Smithuis, F., Eziefula, A., Bousema, T., Drakeley, C., Chotivanich, K., Imwong, M., Pukrittayakamee, S., Prachumsri, J., Chu, C., Andolina, C., Bancone, G., Hien, T., Mayxay, M., Taylor, W., … Nosten, F. (2014). Malaria Journal, 13(1), 483.