Category
Dr
James
Watson
Associate Director
Co-Lead Malaria Chemoprevention Theme
Email
Research Theme
Malaria
Chagas
WWARN
James Watson joined IDDO in March 2023 as Associate Director.
He is a Sir Henry Dale Fellow funded by the Wellcome Trust working on improving the diagnosis and treatment of severe falciparum malaria.
James is a statistician by training and previously worked at the Mahidol Oxford Tropical Medicine Research Unit in Bangkok for seven years before moving to the Oxford University Clinical Research Unit in Viet Nam.
His research interests also include the radical cure of Plasmodium vivax malaria, SARS-CoV-2 antivirals, Chagas disease, snakebite and adaptive trial design.
All Publications
Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision
Watson, J., Ndila, C., Uyoga, S., Macharia, A., Nyutu, G., Shebe, M., Ngetsa, C., Mturi, N., Peshu, N., Tsofa, B., Rockett, K., Leopold, S., Kingston, H., George, E., Maitland, K., Day, N., Dondorp, A., Bejon, P., Williams, T., … White, N. (2021). ELife, 10.
Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision.
Watson, J., Ndila, C., Uyoga, S., Macharia, A., Nyutu, G., Mohammed, S., Ngetsa, C., Mturi, N., Peshu, N., Tsofa, B., Rockett, K., Leopold, S., Kingston, H., George, E., Maitland, K., Day, N., Dondorp, A., Bejon, P., Williams, T., … White, N. (2021). ELife, 10.
Definitions matter: heterogeneity of COVID-19 disease severity criteria and incomplete reporting compromise meta-analysis
Guérin, P., McLean, A., Rashan, S., Lawal, A., Watson, J., Strub-Wourgaft, N., & White, N. (2021).
Tafenoquine for the prevention of Plasmodium vivax malaria relapse
Watson, J., Nekkab, N., & White, M. (2021). Lancet Microbe, 2(5), E175 - E176.
Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria
Awab, G., Aaram, F., Jamornthanyawat, N., Suwannasin, K., Pagornrat, W., Watson, J., Woodrow, C., Dondorp, A., Day, N., Imwong, M., & White, N. (2021). ELife, 10.
Prediction of disease severity in young children presenting with acute febrile illness in resource-limited settings: a protocol for a prospective observational study
Chandna, A., Aderie, E., Ahmad, R., Arguni, E., Ashley, E., Cope, T., Dat, V., Day, N., Dondorp, A., Illanes, V., De Jesus, J., Jimenez, C., Kain, K., Suy, K., Koshiaris, C., Lasry, E., Mayxay, M., Mondal, D., Perera, R., … Lubell, Y. (2021). BMJ Open, 11(1).
Optimal design for phase 2 studies of SARS-CoV-2 antiviral drugs
Watson, J., Kissler, S., Day, N., Grad, Y., & White, N. (2021).
Improving the diagnosis of severe malaria in African children using platelet counts and plasma Pf HRP2 concentrations
Watson, J., Uyoga, S., Wanjiku, P., Makale, J., Nyutu, G., Mturi, N., George, E., Woodrow, C., Day, N., Bejon, P., Opoka, R., Dondorp, A., John, C., Maitland, K., Williams, T., & White, N. (2021). In medRxiv.
The prognostic and diagnostic value of intraleukocytic malaria pigment: an individual patient data pooled meta-analysis of 32,000 patients with severe falciparum malaria in Africa and Asia
Srinamon, K., Watson, J., Silamut, K., Intharabut, B., Phu, N., Diep, P., Lyke, K., Fanello, C., Seidlein, L., Chotivanich, K., Dondorp, A., Day, N., & White, N. (2021). In medRxiv.
Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
White, N., Watson, J., & Baird, K. (2021). In Authorea Preprints.
The WHO guideline on drugs to prevent COVID-19: small numbers- big conclusions.
Schilling, W., Callery, J., Chandna, A., Hamers, R., Watson, J., & White, N. (2021). Wellcome Open Research, 6, 71.
Time-to-death is a potential confounder in observational studies of blood transfusion in severe malaria.
Watson, J., Leopold, S., Dondorp, A., & White, N. (2021). The Lancet. Haematology, 8(1), e12.
The WHO guideline on drugs to prevent COVID-19: small numbers- big conclusions.
Schilling, W., Callery, J., Chandna, A., Hamers, R., Watson, J., & White, N. (2021). Wellcome Open Research, 6, 71.
Questioning the claimed superiority of malaria parasite ex vivo viability reduction over observed parasite clearance rate?
White, N., & Watson, J. (2020). The Journal of Infectious Diseases, 224(4), 738-739.
Is malaria parasite ex-vivo viability reduction really "superior" to observed parasite clearance rate?
White, N., & Watson, J. (2020). The Journal of Infectious Diseases.
A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar
Watson, J., Lamb, T., Holmes, J., Warrell, D., Thwin, K., Aung, Z., Oo, M., Nwe, M., Smithuis, F., & Ashley, E. (2020). PLoS Neglected Tropical Diseases, 14(11).
Correction: COVID-19 prevention and treatment: A critical analysis of chloroquine and hydroxychloroquine clinical pharmacology.
PLOS Medicine Staff. (2020). PLoS Medicine, 17(10), e1003445.
Chloroquine/ hydroxychloroquine prevention of coronavirus disease (COVID-19) in the healthcare setting; protocol for a randomised, placebo-controlled prophylaxis study (COPCOV)
Schilling, W., Callery, J., Taylor, W., Mukaka, M., Ekkapongpisit, M., Watson, J., Chandna, A., Panapipat, S., Tubprasert, J., Yuentrakul, P., Waithira, N., Cope, T., Dhorda, M., Cruz, C., von Seidlein, L., Milton, J., LLewelyn, M., Adler, A., Chotivanich, K., … White, N. (2020). Wellcome Open Research, 5, 241-241.
A cautionary note on the use of unsupervised machine learning algorithms to characterise malaria parasite population structure from genetic distance matrices
Watson, J., Taylor, A., Ashley, E., Dondorp, A., Buckee, C., White, N., & Holmes, C. (2020). PLoS Genetics, 16(10).
Effect of hydroxychloroquine in hospitalized patients with COVID-19
Horby, P., Mafham, M., Linsell, L., Bell, J., Staplin, N., Emberson, J., Tarning, J., Watson, J., White, N., Juszczak, E., Haynes, R., & Landray, M. (2020). New England Journal of Medicine, 383(21), 2030-2040.
Correction to: Graphing and reporting heterogeneous treatment effects through reference classes.
Watson, J., & Holmes, C. (2020). Trials, 21(1), 865.
COVID-19 prevention and treatment: A critical analysis of chloroquine and hydroxychloroquine clinical pharmacology
White, N., Watson, J., Hoglund, R., Chan, X., Cheah, P., & Tarning, J. (2020). PLOS Medicine, 17(9).
Concentration-dependent mortality of chloroquine in overdose
Watson, J., Tarning, J., Hoglund, M., Baud, F., Megarbane, B., Clemessy, J.-L., & White, N. (2020). ELife, 9.
Non-adherence in non-inferiority trials: pitfalls and recommendations
Mo, Y., Lim, C., Watson, J., White, N., & Cooper, B. (2020). BMJ, 370.
Estimating the proportion of plasmodium vivax recurrences caused by relapse: A systematic review and meta-analysis
Commons, R., Simpson, J., Watson, J., White, N., & Price, R. (2020). American Journal of Tropical Medicine and Hygiene.