WWARN Clinical Trials Publication Library

A comprehensive, regularly updated compilation of all antimalarial clinical efficacy trials conducted and published since 1946. 

Medic with patients in clinic
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Credit: Mehul / Pailin

Are you a malaria researcher looking to review existing clinical efficacy trials in the field? The free-to use WWARN Clinical Trials library is a comprehensive living systematic review of human-infecting plasmodium antimalarial efficacy clinical trials, from 1946 to the present day.

Access the library

Over 1,500 Clinical Efficacy Publication 

Data over over 90 countries

Data from over 400,000 patients

 

The WWARN  Clinical Trials Publication  Library (WCTL) literature search  identifies antimalarial efficacy clinical trials on human plasmodium malaria published since 1946. Publication-level data is extracted to create a searchable  library, which is updated twice a year, to include the latest published trials. This open-access, downloadable database can be searched rapidly for relevant studies with pre-extracted publication-level data, thus speeding up evidence identification and synthesis.

The library is officially registered on the Open Science Framework, which means that our methodology is fully transparent and freely available publicly, to allow researchers to customise extraction and to increase reproducibility. 

Publication-level statistics in the library include:

  • P. Falciparum (1,188 studies), P. vivax (351 studies), both (102 studies), as well as other Plasmodium species (70)
  • Studies conducted in Africa (694), Asia (623), and South and Central America (115)
  • Children under age 5 (814 studies)
  • Pregnant women (68 studies)
  • Randomised (767) as well as single blinded (164) studies

 

A full list of variables included in the library:

1

Accession Number of Publication

2

Repeat Instrument

3

Repeat Instance

4

Authors of the Publication

5

Year of Publication

6

Title of Publication

7

Journal of Publication

8

Journal Volume

9

Issue Number

10

Pages of Article

11

Clinical Trials Registration Number

12

Region of Study

13

Country of Study

14

Language of the full text PDF

15

First Year of Patient Recruitment

16

Last Year of Patient Recruitment

17

Was the Study Randomized?

18

Was the Study Blinded?

19

Did the study recruit subjects younger than 5 years of age?

20

Did the study recruit subjects ages 5 to 15 years?

21

Did the study recruit subjects older than 15 years?

22

Did the study recruit Pregnant Women?

23

Length of Follow-up (in Days)

24

Plasmodium falciparum included in the study?

25

Plasmodium vivax included in the study?

26

Plasmodium ovale included in the study?

27

Plasmodium malariae included in the study?

28

Plasmodium knowlesi included in the study?

29

Mixed Infection (Pf+Pv) included in the study?

30

Does this study contain an ACT?

31

Number of Patients Recruited in this Treatment Arm

32

Verified Treatment Name

33

Was the drug administration supervised in this Treatment Arm?

34

Formulation of Drugs in this Treatment Arm (choice=Fixed-Dose Combination)

35

Formulation of Drugs in this Treatment Arm (choice=Loose)

36

Formulation of Drugs in this Treatment Arm (choice=Co-blister Pack)

37

Formulation of Drugs in this Treatment Arm (choice=Not Specified)

38

Manufacturer of Drugs in the Treatment Arm

39

Name of Drug 1 in this Treatment Arm

40

Name of Drug 2 in this Treatment Arm

41

Name of Drug 3 in this Treatment Arm

42

Name of Drug 4 in this Treatment Arm

43

Name of Drug 5 in this Treatment Arm

44

Name of Drug 6 in this Treatment Arm

45

Is there an ACT in this Treatment Arm?

46

Country of the study site

47

Location of the study

48

Latitude of this location

49

Longitude of this location