Category
Dr
Makoto
Saito
Head of Antimicrobial Resistance Disease Theme
Email
Research Theme
Malaria
WWARN
Antimicrobial resistance
Makoto is an infectious disease physician and a clinical epidemiologist. Since joining WWARN/IDDO in 2015, he has worked on malaria in pregnancy, supporting the 2022 revision of the WHO malaria treatment guidelines to recommend artemether-lumefantrine for women in their first trimester.
His research interests extend broadly to the epidemiology of clinical infectious diseases, including nosocomial bacterial infections and antimicrobial resistance (AMR). Currently, his research focuses on evidence synthesis related to AMR, particularly in low- and middle-income countries, to support evidence-based actions against AMR where data is limited.
He completed his DPhil at the Nuffield Department of Medicine, Oxford (2015-2019, Clarendon Scholar, NDM Graduate Prize 2019). He earned an MD from the University of Tokyo, as well as an MSc in Tropical Medicine and International Health and an MSc in Epidemiology from the London School of Hygiene and Tropical Medicine. He is a certified epidemiologist and infectious disease specialist in Japan and a fellow of the Japanese Society of Internal Medicine. He is a Wolfson College Research Fellow in Sciences.
Key Publications
Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study
Saito, M., Phyo, A., Chu, C., Proux, S., Rijken, M., Beau, C., Win, H., Archasuksan, L., Wiladphaingern, J., Phu, N., Hien, T., Day, N., Dondorp, A., White, N., Nosten, F., & McGready, R. (2023). BMC Medicine, 21.
Pregnancy outcomes after first-trimester treatment with artemisinin derivatives versus non-artemisinin antimalarials: a systematic review and individual patient data meta-analysis
Saito, M., McGready, R., Tinto, H., Rouamba, T., Mosha, D., Rulisa, S., Kariuki, S., Desai, M., Manyando, C., Njunju, E., Sevene, E., Vala, A., Augusto, O., Clerk, C., Were, E., Mrema, S., Kisinza, W., Byamugisha, J., Kagawa, M., … Dellicour, S. (2022). The Lancet, 401(10371), 118-130.
A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border.
Saito, M., Carrara, V., Gilder, M., Min, A., Tun, N., Pimanpanarak, M., Viladpai-Nguen, J., Paw, M., Haohankhunnatham, W., Konghahong, K., Phyo, A., Chu, C., Turner, C., Lee, S., Duanguppama, J., Imwong, M., Bancone, G., Proux, S., Singhasivanon, P., … McGready, R. (2021). BMC Medicine, 19(1).
Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Saito, M., Mansoor, R., Kennon, K., Anvikar, A., Ashley, E., Chandramohan, D., Cohee, L., D’Alessandro, U., Genton, B., Gilder, M., Juma, E., Kalilani-Phiri, L., Kuepfer, I., Laufer, M., Lwin, K., Meshnick, S., Mosha, D., Muehlenbachs, A., Mwapasa, V., … Guérin, P. (2020). BMC Medicine, 18(1).
All Publications
Submicroscopic malaria in pregnancy and associated adverse pregnancy events: A case-cohort study of 4,352 women on the Thailand–Myanmar border
Gilder, M., Saito, M., Haohankhunnatham, W., Ling, C., Gornsawun, G., Bancone, G., Chu, C., Christensen, P., Imwong, M., Charunwatthana, P., Tun, N., Min, A., Carrara, V., Proux, S., White, N., Nosten, F., & McGready, R. (2025). PLoS Medicine, 22(3).
MicroRNA in neuroexosome as a potential biomarker for HIV-associated neurocognitive disorders
Arizono, K., Sedohara, A., Tuvshinjargal, K., Tanaka, T., Koga, M., Nakahara, F., Ootani, A., Kanno, Y., Ikeuchi, K., Saito, M., Adachi, E., Tsutsumi, T., & Yotsuyanagi, H. (2025). Journal of NeuroVirology, 1-19.
Enhancer of zeste homolog 1/2 dual inhibitor valemetostat outperforms enhancer of zeste homolog 2-selective inhibitors in reactivating latent HIV-1 reservoirs ex vivo
Sedohara, A., Koibuchi, T., Yamagishi, M., Koga, M., Arizono, K., Ikeuchi, K., Kikuchi, T., Saito, M., Adachi, E., Tsutsumi, T., Honma, D., Araki, K., Uchimaru, K., & Yotsuyanagi, H. (2025). Frontiers in Microbiology, 16.
Clinical impact of the use of chronic suppressive antibiotics against recurrent ventricular assist device infections.
Yamamoto, S., Okamoto, K., Kumamaru, H., Saito, M., Ito, H., Yamashita, M., Kanno, Y., Ikeda, M., Harada, S., Okugwa, S., Kimura, M., Kinoshita, O., Ono, M., Tsutsumi, T., & Moriya, K. (2024). Microbiology Spectrum, 12(11), e0039824.
Hepatitis B Virus Reactivation after Switch to Cabotegravir/Rilpivirine in Patient with Low Hepatitis B Surface Antibody.
Adachi, E., Sedohara, A., Arizono, K., Takahashi, K., Otani, A., Kanno, Y., Saito, M., Koga, M., & Yotsuyanagi, H. (2024). Emerging Infectious Diseases, 30(8), 1668-1671.
Attenuation of hepatitis A antibody after immunization with hepatitis A vaccine (Aimmugen) in people living with HIV.
Koga, M., Saito, M., Kubota, M., Senkoji, T., Adachi, E., Ikeuchi, K., Kikuchi, T., Otani, A., Takahashi, K., Tsutsumi, T., & Yotsuyanagi, H. (2024). Hepatology Research : The Official Journal of the Japan Society of Hepatology, 54(5), 487-494.
Comparison of lumefantrine, mefloquine, and piperaquine concentrations between capillary plasma and venous plasma samples in pregnant women with uncomplicated falciparum and vivax malaria
Saito, M., Wilaisrisak, P., Pimanpanarak, M., Viladpai-Nguen, J., Paw, M., Koesukwiwat, U., Tarning, J., White, N., Nosten, F., & McGready, R. (2024). Antimicrobial Agents and Chemotherapy, 68(5).
Favorable Virological Outcome, Characteristics of Injection Site Reactions, Decrease in Renal Function Biomarkers in Asian People with HIV Receiving Long-Acting Cabotegravir Plus Rilpivirine.
Adachi, E., Saito, M., Otani, A., Koga, M., & Yotsuyanagi, H. (2024). AIDS Research and Human Retroviruses, 40(4), 216-222.
Characterization of mutations in hepatitis B virus DNA isolated from Japanese HBsAg-positive blood donors in 2021 and 2022.
Sedohara, A., Takahashi, K., Arai, K., Arizono, K., Tuvshinjargal, K., Saito, M., Nakahara, F., Tsutsumi, T., Ikeuchi, K., Adachi, E., & Yotsuyanagi, H. (2024). Archives of Virology, 169(5), 103.
Community-acquired Staphylococcus aureus bacteremia among people who inject drugs: a national cohort study in England, 2017–2020
McGuire, E., Collin, S., Brown, C., & Saito, M. (2024). Clinical Infectious Diseases, 78(6), 1443-1450.
Brief communications: changes in inflammatory biomarkers and lipid profiles after switching to long-acting cabotegravir plus rilpivirine.
Adachi, E., Saito, M., Otani, A., Koga, M., & Yotsuyanagi, H. (2024). AIDS Research and Therapy, 21(1), 1.
Injection drug use and sexually transmitted infections among men who have sex with men: A retrospective cohort study at an HIV/AIDS referral hospital in Tokyo, 2013-2022.
Ikeuchi, K., Saito, M., Adachi, E., Koga, M., Okushin, K., Tsutsumi, T., & Yotsuyanagi, H. (2023). Epidemiology and Infection, 151, e195.
Antiviral efficacy against and replicative fitness of an XBB.1.9.1 clinical isolate.
Uraki, R., Ito, M., Kiso, M., Yamayoshi, S., Iwatsuki-Horimoto, K., Sakai-Tagawa, Y., Imai, M., Koga, M., Yamamoto, S., Adachi, E., Saito, M., Tsutsumi, T., Otani, A., Fukushi, S., Watanabe, S., Suzuki, T., Kikuchi, T., Yotsuyanagi, H., Maeda, K., & Kawaoka, Y. (2023). IScience, 26(11), 108147.
Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study
Saito, M., Phyo, A., Chu, C., Proux, S., Rijken, M., Beau, C., Win, H., Archasuksan, L., Wiladphaingern, J., Phu, N., Hien, T., Day, N., Dondorp, A., White, N., Nosten, F., & McGready, R. (2023). BMC Medicine, 21.
Characteristics and in-hospital mortality of patients with COVID-19 from the first to fifth waves of the pandemic in 2020 and 2021 in the Japanese Medical Data Vision database
Suzuki, T., Taniguchi, Y., Komiyama, J., Kuno, T., Adomi, M., Abe, T., Inokuchi, R., Miyawaki, A., Imai, S., Saito, M., Ohbe, H., Aso, S., Kamio, T., Tamiya, N., & Iwagami, M. (2023). Heliyon, 9(9).
Incidence of sexually transmitted hepatitis C virus infection among men who have sex with men in Japan from 2009 to 2023
Adachi, E., Saito, M., Kikuchi, T., Ikeuchi, K., Koga, M., Tsutsumi, T., & Yotsuyanagi, H. (2023). Journal of Medical Virology, 95(8).
Transient decrease in T cells and atypical lymphocyte proliferation after the onset of mpox.
Adachi, E., Saito, M., Otani, A., Koga, M., & Yotsuyanagi, H. (2023). Journal of Medical Virology, 95(8), e29021.
Mpox associated with Panton-Valentin leucocidin-producing methicillin-resistant Staphylococcus aureus among people with HIV.
Adachi, E., Ikeuchi, K., Otani, A., Saito, M., Koga, M., & Yotsuyanagi, H. (2023). Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, 29(7), 710-712.
Differences among epitopes recognized by neutralizing antibodies induced by SARS-CoV-2 infection or COVID-19 vaccination
Yamamoto, S., Yamayoshi, S., Ito, M., Sakai-Tagawa, Y., Nakachi, I., Baba, R., Kamimoto, S., Ogura, T., Hagiwara, S., Kato, H., Nakajima, H., Uwamino, Y., Yagi, K., Sugaya, N., Nagai, H., Saito, M., Adachi, E., Koga, M., Tsutsumi, T., … Kawaoka, Y. (2023). IScience, 26(7).
Outbreaks of COVID-19 in a tuberculosis treatment sanatorium on the Thailand-Myanmar border: a retrospective cohort analysis
Aung, H., Swe, L., Saito, M., Lesseps, S., Janurian, N., Tun, W., Maung Maung, B., Than, A., Watthanaworawit, W., Kaewphanderm, N., Gornsawun, G., Pyae Phyo, A., & Nosten, F. (2023). Wellcome Open Research, 8.
Efficacy of antivirals and mRNA vaccination against an XBF clinical isolate
Uraki, R., Ito, M., Kiso, M., Yamayoshi, S., Iwatsuki-Horimoto, K., Sakai-Tagawa, Y., Imai, M., Koga, M., Yamamoto, S., Adachi, E., Saito, M., Tsutsumi, T., Otani, A., Kashima, Y., Kikuchi, T., Theiler, J., Yotsuyanagi, H., Suzuki, Y., Korber, B., & Kawaoka, Y. (2023). Lancet Regional Health – Western Pacific, 34.
Severe falciparum and vivax malaria on the Thailand-Myanmar border: a review of 1503 cases
Chu, C., Stolbrink, M., Stolady, D., Saito, M., Beau, C., Choun, K., Wah, T., Mu, N., Htoo, K., Nu, B., Keereevijit, A., Wiladpaingern, J., Carrara, V., Phyo, A., Lwin, K., Luxemburger, C., Proux, S., Charunwatthana, P., McGready, R., … Nosten, F. (2023). Clinical Infectious Diseases, 77(5), 721-728.
A multicenter randomized controlled trial to evaluate the efficacy and safety of nelfinavir in patients with mild COVID-19
Miyazaki, T., Hosogaya, N., Fukushige, Y., Takemori, S., Morimoto, S., Yamamoto, H., Hori, M., Ozawa, Y., Shiko, Y., Inaba, Y., Kurokawa, T., Hanaoka, H., Iwanami, S., Kim, K., Iwami, S., Watashi, K., Miyazawa, K., Umeyama, T., Yamagoe, S., … Kohno, S. (2023). Microbiology Spectrum, 11(3).
Efficacy of antivirals and bivalent mRNA vaccines against SARS-CoV-2 isolate CH.1.1.
Uraki, R., Ito, M., Kiso, M., Yamayoshi, S., Iwatsuki-Horimoto, K., Sakai-Tagawa, Y., Furusawa, Y., Imai, M., Koga, M., Yamamoto, S., Adachi, E., Saito, M., Tsutsumi, T., Otani, A., Kashima, Y., Kikuchi, T., Yotsuyanagi, H., Suzuki, Y., & Kawaoka, Y. (2023). The Lancet. Infectious Diseases, 23(5), 525-526.
Antiviral and bivalent vaccine efficacy against an omicron XBB.1.5 isolate.
Uraki, R., Ito, M., Kiso, M., Yamayoshi, S., Iwatsuki-Horimoto, K., Furusawa, Y., Sakai-Tagawa, Y., Imai, M., Koga, M., Yamamoto, S., Adachi, E., Saito, M., Tsutsumi, T., Otani, A., Kikuchi, T., Yotsuyanagi, H., Halfmann, P., Pekosz, A., & Kawaoka, Y. (2023). The Lancet. Infectious Diseases, 23(4), 402-403.