Category
Dr
Makoto
Saito
Head of Antimicrobial Resistance Disease Theme
Email
Research Theme
Malaria
WWARN
Antimicrobial resistance
Makoto is an infectious disease physician and a clinical epidemiologist. Since joining WWARN/IDDO in 2015, he has worked on malaria in pregnancy, supporting the 2022 revision of the WHO malaria treatment guidelines to recommend artemether-lumefantrine for women in their first trimester.
His research interests extend broadly to the epidemiology of clinical infectious diseases, including nosocomial bacterial infections and antimicrobial resistance (AMR). Currently, his research focuses on evidence synthesis related to AMR, particularly in low- and middle-income countries, to support evidence-based actions against AMR where data is limited.
He completed his DPhil at the Nuffield Department of Medicine, Oxford (2015-2019, Clarendon Scholar, NDM Graduate Prize 2019). He earned an MD from the University of Tokyo, as well as an MSc in Tropical Medicine and International Health and an MSc in Epidemiology from the London School of Hygiene and Tropical Medicine. He is a certified epidemiologist and infectious disease specialist in Japan and a fellow of the Japanese Society of Internal Medicine. He is a Wolfson College Research Fellow in Sciences.
All Publications
Multicenter, single-blind, randomized controlled study of the efficacy and safety of favipiravir and nafamostat mesilate in patients with COVID-19 pneumonia
Ikeda, M., Okugawa, S., Kashiwabara, K., Moritoyo, T., Kanno, Y., Jubishi, D., Hashimoto, H., Okamoto, K., Tsushima, K., Uchida, Y., Mitsumura, T., Igari, H., Tsutsumi, T., Araoka, H., Yatera, K., Yamamoto, Y., Nakamura, Y., Otani, A., Yamashita, M., … Moriya, K. (2023). International Journal of Infectious Diseases, 128, 355-363.
Humoral immune evasion of the omicron subvariants BQ.1.1 and XBB.
Uraki, R., Ito, M., Furusawa, Y., Yamayoshi, S., Iwatsuki-Horimoto, K., Adachi, E., Saito, M., Koga, M., Tsutsumi, T., Yamamoto, S., Otani, A., Kiso, M., Sakai-Tagawa, Y., Ueki, H., Yotsuyanagi, H., Imai, M., & Kawaoka, Y. (2023). The Lancet. Infectious Diseases, 23(1), 30-32.
Outbreaks of COVID-19 in a tuberculosis treatment sanatorium on the Thailand-Myanmar border: a retrospective cohort analysis.
Aung, H., Swe, L., Saito, M., Lesseps, S., Janurian, N., Tun, W., Maung Maung, B., Than, A., Watthanaworawit, W., Kaewphanderm, N., Gornsawun, G., Pyae Phyo, A., & Nosten, F. (2023). Wellcome Open Research, 8, 272.
Outbreaks of COVID-19 in a tuberculosis treatment sanatorium on the Thailand-Myanmar border: a retrospective cohort analysis
Aung, H., Swe, L., Saito, M., Lesseps, S., Janurian, N., Tun, W., Maung Maung, B., Than, A., Watthanaworawit, W., Kaewphanderm, N., Gornsawun, G., Pyae Phyo, A., & Nosten, F. (2023).
Changes in rapid plasma reagin titers in patients with syphilis before and after treatment: A retrospective cohort study in an HIV/AIDS referral hospital in Tokyo.
Ikeuchi, K., Fukushima, K., Tanaka, M., Yajima, K., Saito, M., & Imamura, A. (2023). PloS One, 18(9), e0292044.
In Vitro Efficacy of Antiviral Agents against Omicron Subvariant BA.4.6.
Takashita, E., Yamayoshi, S., Halfmann, P., Wilson, N., Ries, H., Richardson, A., Bobholz, M., Vuyk, W., Maddox, R., Baker, D., Friedrich, T., O’Connor, D., Uraki, R., Ito, M., Sakai-Tagawa, Y., Adachi, E., Saito, M., Koga, M., Tsutsumi, T., … Kawaoka, Y. (2022). The New England Journal of Medicine, 387(22), 2094-2097.
Pregnancy outcomes after first-trimester treatment with artemisinin derivatives versus non-artemisinin antimalarials: a systematic review and individual patient data meta-analysis
Saito, M., McGready, R., Tinto, H., Rouamba, T., Mosha, D., Rulisa, S., Kariuki, S., Desai, M., Manyando, C., Njunju, E., Sevene, E., Vala, A., Augusto, O., Clerk, C., Were, E., Mrema, S., Kisinza, W., Byamugisha, J., Kagawa, M., … Dellicour, S. (2022). The Lancet, 401(10371), 118-130.
Favorable Outcome Following Sotrovimab Monoclonal Antibody in a Patient with Prolonged SARS-CoV-2 Omicron Infection with HIV/AIDS.
Adachi, E., Saito, M., Koga, M., Tsutsumi, T., & Yotsuyanagi, H. (2022). Internal Medicine (Tokyo, Japan), 61(22), 3459-3462.
Casirivimab/Imdevimab for Active COVID-19 Pneumonia Which Persisted for Nine Months in a Patient with Follicular Lymphoma during Anti-CD20 Therapy.
Nagai, H., Saito, M., Adachi, E., Sakai-Tagawa, Y., Yamayoshi, S., Kiso, M., Kawamata, T., Koga, M., Kawaoka, Y., Tsutsumi, T., & Yotsuyanagi, H. (2022). Japanese Journal of Infectious Diseases, 75(6), 608-611.
Characterization of the SARS-CoV-2 B.1.621 (Mu) variant.
Halfmann, P., Kuroda, M., Armbrust, T., Theiler, J., Balaram, A., Moreno, G., Accola, M., Iwatsuki-Horimoto, K., Valdez, R., Stoneman, E., Braun, K., Yamayoshi, S., Somsen, E., Baczenas, J., Mitamura, K., Hagihara, M., Adachi, E., Koga, M., McLaughlin, M., … Kawaoka, Y. (2022). Science Translational Medicine, 14(657), eabm4908.
Anti-spike protein antibody titer at the time of breakthrough infection of SARS-CoV-2 omicron.
Adachi, E., Nagai, E., Saito, M., Isobe, M., Konuma, T., Koga, M., Tsutsumi, T., Nannya, Y., & Yotsuyanagi, H. (2022). Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, 28(7), 1015-1017.
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2.
Uraki, R., Kiso, M., Iida, S., Imai, M., Takashita, E., Kuroda, M., Halfmann, P., Loeber, S., Maemura, T., Yamayoshi, S., Fujisaki, S., Wang, Z., Ito, M., Ujie, M., Iwatsuki-Horimoto, K., Furusawa, Y., Wright, R., Chong, Z., Ozono, S., … Kawaoka, Y. (2022). Nature, 607(7917), 119-127.
Association between pre-admission anticoagulation and in-hospital death, venous thromboembolism, and major bleeding among hospitalized COVID-19 patients in Japan.
Adomi, M., Kuno, T., Komiyama, J., Taniguchi, Y., Abe, T., Miyawaki, A., Imai, S., Morita, K., Saito, M., Ohbe, H., Kamio, T., Tamiya, N., & Iwagami, M. (2022). Pharmacoepidemiology and Drug Safety, 31(6), 680-688.
Transient depletion of T cells during COVID-19 and seasonal influenza in people living with HIV.
Adachi, E., Saito, M., Nagai, H., Ikeuchi, K., Koga, M., Tsutsumi, T., & Yotsuyanagi, H. (2022). Journal of Medical Virology, 94(5), 1789-1791.
Correlation analysis between gut microbiota alterations and the cytokine response in patients with coronavirus disease during hospitalization
Mizutani, T., Ishizaka, A., Koga, M., Ikeuchi, K., Saito, M., Adachi, E., Yamayoshi, S., Iwatsuki-Horimoto, K., Yasuhara, A., Kiyono, H., Matano, T., Suzuki, Y., Tsutsumi, T., Kawaoka, Y., & Yotsuyanagi, H. (2022). Microbiology Spectrum, 10(2).
Predictors associated with a better response to the Japanese aluminum-free hepatitis A vaccine, Aimmugen® , for people living with HIV.
Koga, M., Senkoji, T., Kubota, M., Ishizaka, A., Mizutani, T., Sedohara, A., Ikeuchi, K., Kikuchi, T., Adachi, E., Saito, M., Koibuchi, T., Hosomichi, K., Ohashi, J., Kawana-Tachikawa, A., Matano, T., Tsutsumi, T., & Yotsuyanagi, H. (2022). Hepatology Research : The Official Journal of the Japan Society of Hepatology, 52(3), 227-234.
Comparison of patient characteristics and in-hospital mortality between patients with COVID-19 in 2020 and those with influenza in 2017-2020: a multicenter, retrospective cohort study in Japan.
Taniguchi, Y., Kuno, T., Komiyama, J., Adomi, M., Suzuki, T., Abe, T., Ishimaru, M., Miyawaki, A., Saito, M., Ohbe, H., Miyamoto, Y., Imai, S., Kamio, T., Tamiya, N., & Iwagami, M. (2022). The Lancet Regional Health. Western Pacific, 20, 100365.
Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant.
Takashita, E., Kinoshita, N., Yamayoshi, S., Sakai-Tagawa, Y., Fujisaki, S., Ito, M., Iwatsuki-Horimoto, K., Chiba, S., Halfmann, P., Nagai, H., Saito, M., Adachi, E., Sullivan, D., Pekosz, A., Watanabe, S., Maeda, K., Imai, M., Yotsuyanagi, H., Mitsuya, H., … Kawaoka, Y. (2022). The New England Journal of Medicine, 386(10), 995-998.
Prevalence of HIV infection among non-elderly individuals with hepatitis C in Japan: a population-based cohort study using a health insurance claim data.
Ikeuchi, K., Okushin, K., Saito, M., Adachi, E., Tsutsumi, T., Takura, T., & Yotsuyanagi, H. (2022). BMC Infectious Diseases, 22(1), 167.
Placental histopathology in preterm birth with confirmed maternal infection: A systematic literature review
Min, A., Saito, M., Simpson, J., Kennedy, S., Nosten, F., & McGready, R. (2021). PLOS ONE, 16(8).
Association of HLA-DRB1*09:01 with severe COVID-19.
Anzurez, A., Naka, I., Miki, S., Nakayama-Hosoya, K., Isshiki, M., Watanabe, Y., Nakamura-Hoshi, M., Seki, S., Matsumura, T., Takano, T., Onodera, T., Adachi, Y., Moriyama, S., Terahara, K., Tachikawa, N., Yoshimura, Y., Sasaki, H., Horiuchi, H., Miyata, N., … Kawana-Tachikawa, A. (2021). HLA, 98(1), 37-42.
Characterization of a new SARS-CoV-2 variant that emerged in Brazil.
Imai, M., Halfmann, P., Yamayoshi, S., Iwatsuki-Horimoto, K., Chiba, S., Watanabe, T., Nakajima, N., Ito, M., Kuroda, M., Kiso, M., Maemura, T., Takahashi, K., Loeber, S., Hatta, M., Koga, M., Nagai, H., Yamamoto, S., Saito, M., Adachi, E., … Kawaoka, Y. (2021). Proceedings of the National Academy of Sciences of the United States of America, 118(27), e2106535118.
A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border.
Saito, M., Carrara, V., Gilder, M., Min, A., Tun, N., Pimanpanarak, M., Viladpai-Nguen, J., Paw, M., Haohankhunnatham, W., Konghahong, K., Phyo, A., Chu, C., Turner, C., Lee, S., Duanguppama, J., Imwong, M., Bancone, G., Proux, S., Singhasivanon, P., … McGready, R. (2021). BMC Medicine, 19(1).
Longitudinal antibody repertoire in "mild" versus "severe" COVID-19 patients reveals immune markers associated with disease severity and resolution.
Ravichandran, S., Lee, Y., Grubbs, G., Coyle, E., Klenow, L., Akasaka, O., Koga, M., Adachi, E., Saito, M., Nakachi, I., Ogura, T., Baba, R., Ito, M., Kiso, M., Yasuhara, A., Yamada, S., Sakai-Tagawa, Y., Iwatsuki-Horimoto, K., Imai, M., … Khurana, S. (2021). Science Advances, 7(10), eabf2467.
Antibody titers against SARS-CoV-2 decline, but do not disappear for several months
Yamayoshi, S., Yasuhara, A., Ito, M., Akasaka, O., Nakamura, M., Nakachi, I., Koga, M., Mitamura, K., Yagi, K., Maeda, K., Kato, H., Nojima, M., Pattinson, D., Ogura, T., Baba, R., Fujita, K., Nagai, H., Yamamoto, S., Saito, M., … Kawaoka, Y. (2021). EClinicalMedicine, 32.