Category
Dr
Makoto
Saito
Head of Antimicrobial Resistance Disease Theme
Email
Research Theme
Malaria
WWARN
Antimicrobial resistance
Makoto is an infectious disease physician and a clinical epidemiologist. Since joining WWARN/IDDO in 2015, he has worked on malaria in pregnancy, supporting the 2022 revision of the WHO malaria treatment guidelines to recommend artemether-lumefantrine for women in their first trimester.
His research interests extend broadly to the epidemiology of clinical infectious diseases, including nosocomial bacterial infections and antimicrobial resistance (AMR). Currently, his research focuses on evidence synthesis related to AMR, particularly in low- and middle-income countries, to support evidence-based actions against AMR where data is limited.
He completed his DPhil at the Nuffield Department of Medicine, Oxford (2015-2019, Clarendon Scholar, NDM Graduate Prize 2019). He earned an MD from the University of Tokyo, as well as an MSc in Tropical Medicine and International Health and an MSc in Epidemiology from the London School of Hygiene and Tropical Medicine. He is a certified epidemiologist and infectious disease specialist in Japan and a fellow of the Japanese Society of Internal Medicine. He is a Wolfson College Research Fellow in Sciences.
All Publications
Seroconversion against SARS-CoV-2 occurred after the recovery in patients with COVID-19.
Yamamoto, S., Saito, M., Nagai, E., Toriuchi, K., Nagai, H., Yotsuyanagi, H., Nakagama, Y., Kido, Y., & Adachi, E. (2021). Journal of Medical Virology, 93(2), 692-694.
Association of coagulopathy with liver dysfunction in patients with COVID-19.
Tsutsumi, T., Saito, M., Nagai, H., Yamamoto, S., Ikeuchi, K., Lim, L., Adachi, E., Koga, M., Okushin, K., Akai, H., Kunimatsu, A., & Yotsuyanagi, H. (2021). Hepatology Research : The Official Journal of the Japan Society of Hepatology, 51(2), 227-232.
Antibody response to SARS-CoV-2 in people living with HIV.
Yamamoto, S., Saito, M., Nagai, E., Toriuchi, K., Nagai, H., Yotsuyanagi, H., Nakagama, Y., Kido, Y., & Adachi, E. (2021). Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 54(1), 144-146.
An Outbreak of USA300 Methicillin-Resistant Staphylococcus aureus Among People With HIV in Japan.
Ikeuchi, K., Adachi, E., Sasaki, T., Suzuki, M., Lim, L., Saito, M., Koga, M., Tsutsumi, T., Kido, Y., Uehara, Y., & Yotsuyanagi, H. (2021). The Journal of Infectious Diseases, 223(4), 610-620.
Electrocardiographic effects of four antimalarials for pregnant women with uncomplicated malaria on the Thailand-Myanmar border: A randomised controlled trial
Saito, M., Yotyingaphiram, W., Cargill, Z., Gilder, M., Min, A., Phyo, A., San, T., Poe, H., Chu, C., White, N., Nosten, F., & McGready, R. (2021). Antimicrobial Agents and Chemotherapy, 65(4).
The human microbiome and COVID-19: A systematic review.
Yamamoto, S., Saito, M., Tamura, A., Prawisuda, D., Mizutani, T., & Yotsuyanagi, H. (2021). PloS One, 16(6), e0253293.
Comparison of Rapid Antigen Tests for COVID-19.
Yamayoshi, S., Sakai-Tagawa, Y., Koga, M., Akasaka, O., Nakachi, I., Koh, H., Maeda, K., Adachi, E., Saito, M., Nagai, H., Ikeuchi, K., Ogura, T., Baba, R., Fujita, K., Fukui, T., Ito, F., Hattori, S.-I., Yamamoto, K., Nakamoto, T., … Kawaoka, Y. (2020). Viruses, 12(12), E1420.
Infiltrative Shadows in COVID-19: Pneumonia or Pulmonary Embolism?
Nagai, H., Yamamoto, S., Saito, M., & Adachi, E. (2020). Internal Medicine (Tokyo, Japan), 59(19), 2443-2444.
Relative Bradycardia in Patients with Mild-to-Moderate Coronavirus Disease, Japan.
Ikeuchi, K., Saito, M., Yamamoto, S., Nagai, H., & Adachi, E. (2020). Emerging Infectious Diseases, 26(10), 2504-2506.
Deleterious effects of malaria in pregnancy on the developing fetus: a review on prevention and treatment with antimalarial drugs
Saito, M., Briand, V., Min, A., & McGready, R. (2020). Lancet Child and Adolescent Health, 4(10), 761-774.
Gargle Lavage as a Safe and Sensitive Alternative to Swab Samples to Diagnose COVID-19: A Case Report in Japan.
Saito, M., Adachi, E., Yamayoshi, S., Koga, M., Iwatsuki-Horimoto, K., Kawaoka, Y., & Yotsuyanagi, H. (2020). Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 71(15), 893-894.
Cases of coronavirus disease-2019 in HIV-infected transgender women.
Adachi, E., Saito, M., Ikeuchi, K., Hoshina, T., & Yotsuyanagi, H. (2020). AIDS (London, England), 34(9), 1435-1436.
Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Saito, M., Mansoor, R., Kennon, K., Anvikar, A., Ashley, E., Chandramohan, D., Cohee, L., D’Alessandro, U., Genton, B., Gilder, M., Juma, E., Kalilani-Phiri, L., Kuepfer, I., Laufer, M., Lwin, K., Meshnick, S., Mosha, D., Muehlenbachs, A., Mwapasa, V., … Guérin, P. (2020). BMC Medicine, 18(1).
Indications and classes of outpatient antibiotic prescriptions in Japan: A descriptive study using the national database of electronic health insurance claims, 2012-2015.
Hashimoto, H., Saito, M., Sato, J., Goda, K., Mitsutake, N., Kitsuregawa, M., Nagai, R., & Hatakeyama, S. (2020). International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 91, 1-8.
Efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a protocol for systematic review and individual patient data (IPD) meta-analysis
Saito, M., Mansoor, R., Kennon, K., McGready, R., Nosten, F., Guérin, P., & Stepniewska, K. (2019). BMJ Open, 9(8).
Optimal duration of follow-up for assessing antimalarial efficacy in pregnancy: a retrospective analysis of a cohort followed up until delivery on the Thailand-Myanmar border
Saito, M., Mansoor, R., Wiladphaingern, J., Paw, M., Pimanpanarak, M., Proux, S., Guérin, P., White, N., Nosten, F., & McGready, R. (2019). Open Forum Infectious Diseases, 6(7).
Antimalarial drugs for treating and preventing malaria in pregnant and lactating women
Saito, M., Gilder, M., McGready, R., & Nosten, F. (2018). Expert Opinion on Drug Safety, 17(11), 1129-1144.
Challenges to primary healthcare services in the management of non-communicable diseases in marginalised populations on the Thailand–Myanmar border: a pilot survey
Saito, M., Keereevijit, A., San, T., Thein, Y., Gilder, M., & McGready, R. (2018). Tropical Doctor, 48(4), 273-277.
Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review
Saito, M., Gilder, M., Nosten, F., Guérin, P., & McGready, R. (2017). Malaria Journal, 16(491), 1-10.
Systematic literature review and meta-analysis of the efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: methodological challenges
Saito, M., Gilder, M., Nosten, F., McGready, R., & Guérin, P. (2017). Malaria Journal, 16(488), 1-17.
Dose-dependent effect of daptomycin on the artificial prolongation of prothrombin time in coagulation abnormalities: in vitro verification.
Hashimoto, H., Saito, M., Kanda, N., Yamamoto, T., Mieno, M., & Hatakeyama, S. (2017). BMC Pharmacology & Toxicology, 18(1), 74.
Dose-dependent artificial prolongation of prothrombin time by interaction between daptomycin and test reagents in patients receiving warfarin: a prospective in vivo clinical study.
Saito, M., Hatakeyama, S., Hashimoto, H., Suzuki, T., Jubishi, D., Kaneko, M., Kume, Y., Yamamoto, T., Suzuki, H., & Yotsuyanagi, H. (2017). Annals of Clinical Microbiology and Antimicrobials, 16(1), 27.
Acute Rheumatic Fever with Erythema Marginatum.
Saito, M., & Hatakeyama, S. (2016). The New England Journal of Medicine, 375(25), 2480.
A pathologically proven case of adult-onset HIV-related lymphocytic interstitial pneumonia with acute exacerbation treated with steroid and antiretroviral therapy.
Saito, M., Hatakeyama, S., Wakabayashi, Y., Yanagimoto, S., Takemura, T., & Yotsuyanagi, H. (2015). Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, 21(12), 868-872.
Clinical Features of Imported Loiasis: A Case Series from the Hospital for Tropical Diseases, London.
Saito, M., Armstrong, M., Boadi, S., Lowe, P., Chiodini, P., & Doherty, T. (2015). The American Journal of Tropical Medicine and Hygiene, 93(3), 607-611.