Professor
Philippe
Guérin
Membre - Comité de pilotage sur le virus Ebola (Ebola SC)
L'Université d’Oxford
Après avoir travaillé comme médecin en France et au Népal, Philippe a rejoint Médecins Sans Frontières où il a acquis une vaste expérience en tant que chercheur travaillant sur le terrain et sur le paludisme et la tuberculose. Il a été pendant six ans directeur scientifique d'Epicentre à Paris, un centre collaborateur de l'Organisation mondiale de la santé pour la recherche en épidémiologie et la réponse aux maladies émergentes. Auparavant, il a été conseiller principal à l'Institut norvégien de santé publique pendant trois ans.
Philippe est directeur de l'Observatoire de données sur les maladies infectieuses (IDDO), dont la mission est de rassembler et d'agréger des données cliniques, laboratoire et épidémiologiques sur certaines maladies sélectionnées liées à la pauvreté et sur les infections émergentes. IDDO s’appuie sur le succès du réseau WWARN (WorldWide Antimalarial Resistance Network), une plateforme scientifiquement indépendante et multidisciplinaire, créée en 2009 pour fournir les informations nécessaires pour empêcher ou alléger la résistance aux médicaments antipaludiques et de cette manière réduire la mortalité, et la morbidité du paludisme.
All Publications
Evaluating drug resistance in visceral leishmaniasis: the challenges
Hendrickx, S., Guerin, P., Caljon, G., Croft, S., & Maes, L. (2016). Parasitology, 145(4), 453-463.
Artemether-lumefantrine and dihydroartemisinin-piperaquine exert inverse selective pressure on Plasmodium Falciparum drug sensitivity-associated haplotypes in Uganda
Taylor, A., Flegg, J., Holmes, C., Guérin, P., Sibley, C., Conrad, M., Dorsey, G., & Rosenthal, P. (2016). Open Forum Infect Dis, 4(1), ofw229.
Efficacy of artemether-lumefantrine in relation to drug exposure in children with and without severe acute malnutrition: an open comparative intervention study in Mali and Niger.
Denoeud-Ndam, L., Dicko, A., Baudin, E., Guindo, O., Grandesso, F., Diawara, H., Sissoko, S., Sanogo, K., Traoré, S., Keita, S., Barry, A., de Smet, M., Lasry, E., Smit, M., Wiesner, L., Barnes, K., Djimde, A., Guerin, P., Grais, R., … Etard, J. (2016). BMC Medicine, 14(167).
Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia
Grist, E., Flegg, J., Humphreys, G., Mas, I., Ashley, E., Humphreys, G., Dhorda, M., Dondorp, A., Hien, T., Maude, R., Mayxay, M., Nosten, F., Newton, P., Price, R., Smithuis, F., White, N., Woodrow, C., Guerin, P., & Gething, P. (2016). International Journal of Health Geographics, 15(37), 1-10.
Beyond open data: realising the health benefits of sharing data
Pisani, E., Aaby, P., Breugelmans, J., Carr, D., Groves, T., Helinski, M., Kamuya, D., Kern, S., Littler, K., Marsh, V., Mboup, S., Merson, L., Sankoh, O., Serafini, M., Schneider, M., Schoenenberger, V., & Guerin, P. (2016). BMJ.
Selection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate-amodiaquine fixed dose combination or artemether-lumefantrine in Liberia
Otienoburu, S., Maïga-Ascofaré, O., Schramm, B., Jullien, V., Jones, J., Zolia, Y., Houzé, P., Ashley, E., Kiechel, Guérin, P., Le Bras, J., & Houzé, S. (2016). Malaria Journal, 15(452), 1-6.
The schistosomiasis clinical trials landscape: A systematic review of antischistosomal treatment efficacy studies and a case for sharing individual participant-level data (IPD)
Julé, A., Vaillant, M., Lang, T., Guérin, P., & Olliaro, P. (2016). PLoS Neglected Tropical Diseases, 7(6).
Combating poor-quality anti-malarial medicines: a call to action
Bassat, Q., Tanner, M., Guerin, P., Stricker, K., & Hamed, K. (2016). Malaria Journal, 15, 302.
Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: A systematic review and meta-analysis of individual patient data
Abdulla, S., Achan, J., Yeka, A., D’Alessandro, U., Adam, I., Alemayehu, B., Allan, R., Temu, E., Allen, E., Barnes, K., Anvikar, A., Valecha, N., Arinaitwe, E., Ashley, E., Carrara, V., McGready, R., Nosten, F., Lee, S., White, N., … Kapulu, M. (2016). BMC Medicine, 14(1).
Ethical challenges in designing and conducting medicine quality surveys
Parker, M., Tabernero, P., Ravinetto, R., Phanouvong, S., Yeung, S., Kitutu, F., Cheah, P., Mayxay, M., Guerin, P., & Newton, P. (2016). Tropical Medicine and International Health, 21(6), 799-806.
Avoiding data dumpsters - Toward equitable and useful data sharing.
Merson, L., Gaye, O., & Guerin, P. (2016). New England Journal of Medicine, 374, 2414-2415.
A link between poor quality antimalarials and malaria drug resistance?
Newton, P., Caillet, C., & Guerin, P. (2016). Expert Review of Anti-Infective Therapy, 14(6), 531-533.
Abundance of megalin and Dab2 is reduced in syncytiotrophoblast during placental malaria, which may contribute to low birth weight
Lybbert, J., Gullingsrud, J., Chesnokov, O., Turyakira, E., Dhorda, M., Guerin, P., Piola, P., Muehlenbachs, A., & Oleinikov, A. (2016). Scientific Reports, 6, Article 24508.
Fake anti-malarials: start with the facts.
Kaur, H., Clarke, S., Lalani, M., Phanouvong, S., Guérin, P., McLoughlin, A., Wilson, B., Deats, M., Plançon, A., Hopkins, H., Miranda, D., & Schellenberg, D. (2016). Malaria Journal, 15, 86.
Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations.
Duru, V., Khim, N., Leang, R., Kim, S., Domergue, A., Kloeung, N., Ke, S., Chy, S., Eam, R., Khean, C., Loch, K., Ken, M., Lek, D., Beghain, J., Ariey, F., Guerin, P., Huy, R., Mercereau-Puijalon, O., Witkowski, B., & Menard, D. (2015). BMC Medicine, 13, 305.
Understanding the mechanisms and drivers of antimicrobial resistance.
Holmes, A., Moore, L., Sundsfjord, A., Steinbakk, M., Regmi, S., Karkey, A., Guerin, P., & Piddock, L. (2015). Lancet (London, England), 387(10014), 176-187.
Artemisinin resistance in Myanmar – Authors' reply
Imwong, M., Tun, K., Hlaing, T., Grist, E., Guerin, P., Smithuis, F., Dondorp, A., Day, N., Nosten, F., White, N., & Woodrow, C. (2015). The Lancet Infectious Diseases, 15(9), 1002-1003.
Microscopy for the detection, identification and quantification of malaria parasites on stained thick and thin blood films in research settings
Dhorda, M., Guerin, P., Baird, J., Carter, J., & Olliaro, P. (2015). World Health Organization, Geneva.
Past and new challenges for malaria control and elimination: the role of operational research for innovation in designing interventions.
Guyant, P., Corbel, V., Guérin, P., Lautissier, A., Nosten, F., Boyer, S., Coosemans, M., Dondorp, A., Sinou, V., Yeung, S., & White, N. (2015). Malaria Journal, 14, 279.
The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data.
(2015). Lancet. Infectious Diseases, 6.
Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker
Tun, K., Imwong, M., Lwin, K., Win, A., Hlaing, T., Hlaing, T., Lin, K., Kyaw, M., Plewes, K., Faiz, M., Dhorda, M., Cheah, P., Pukrittayakamee, S., Ashley, E., Anderson, T., Nair, S., McDew-White, M., Flegg, J., Grist, E., … Woodrow, C. (2015). The Lancet Infectious Diseases, 15(4), 415-421.
Quality assurance of drugs used in clinical trials: proposal for adapting guidelines
Newton, P., Schellenberg, D., Ashley, E., Ravinetto, R., Green, M., ter Kuile, F., Tabernero, P., White, N., & Guerin, P. (2015). BMJ, 350.
The Largest Ebola Outbreak– What Have We Learned So Far
Das, D., Guerin, P., Leroy, S., Abu Sayeed, A., & Faiz, M. (2015). Journal of Medicine, 16(1), 1-4.
Opportunities in visceral leishmaniasis: analysis of large, pooled data sets
Guerin, P. (2015). TROPICAL MEDICINE & INTERNATIONAL HEALTH, 20, 34-34.
Mapping fever aetiologies in malaria-endemic areas: an interactive, open-access, on-line map
Hopkins, H., Thomas, N., Crump, J., Gonzalez, I., Guerin, P., Newton, P., Schellenberg, D., Bell, D., & Reyburn, H. (2015). TROPICAL MEDICINE & INTERNATIONAL HEALTH, 20, 179-179.