Professor
Nicholas
White
Professor of Tropical Medicine
Nick White is a Professor of Tropical Medicine at Mahidol University Thailand and at the University of Oxford, and a consultant physician in acute general medicine at the John Radcliffe Hospital, Oxford, UK. He was Chair of the WWARN Board until 2016, and remains a member of the IDDO Board.
He also co-chaired the World Health Organization antimalarial treatment guidelines committee and the WHO Global Malaria Programme case management cluster. Prof White has served on the editorial advisory boards of international journals including The Lancet and PLoS Medicine. He has contributed to over 1000 peer reviewed scientific publications and has written over 50 book chapters.
Nick White began his work in Thailand in 1980 with the Wellcome Trust Mahidol Oxford Tropical Medicine Research Unit, a collaborative research programme between Mahidol and Oxford Universities. In 1986 he was appointed as Director of the Thailand Unit, and more recently Chair of the Wellcome Trust SE Asian Tropical Medicine Research Programmes.
Nick White’s contribution to tropical medicine and global health was recognised with a UK Knighthood in 2017. His research interests include the epidemiology, pathophysiology and treatment of malaria, melioidosis, typhoid, leptospirosis, dengue, haemorrhagic fever, Japanese encephalitis and tuberculosis.
All Publications
Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.
Mok, S., Ashley, E., Ferreira, P., Zhu, L., Lin, Z., Yeo, T., Chotivanich, K., Imwong, M., Pukrittayakamee, S., Dhorda, M., Nguon, C., Lim, P., Amaratunga, C., Suon, S., Hien, T., Htut, Y., Faiz, M., Onyamboko, M., Mayxay, M., … Bozdech, Z. (2015). Science (New York, N.Y.), 347(6220), 431-435.
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.
White, N., Ashley, E., Recht, J., Delves, M., Ruecker, A., Smithuis, F., Eziefula, A., Bousema, T., Drakeley, C., Chotivanich, K., Imwong, M., Pukrittayakamee, S., Prachumsri, J., Chu, C., Andolina, C., Bancone, G., Hien, T., Mayxay, M., Taylor, W., … Nosten, F. (2014). Malaria Journal, 13(1), 483.
Artemisinin resistance--modelling the potential human and economic costs
Lubell, Y., Dondorp, A., Guérin, P., Drake, T., Meek, S., Ashley, E., Day, N., White, N., & White, L. (2014). Malaria Journal, 13(1), 452.
Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
Kloprogge, F., Jullien, V., Piola, P., Dhorda, M., Muwanga, S., Nosten, F., Day, N., White, N., Guerin, P., & Tarning, J. (2014). The Journal of Antimicrobial Chemotherapy, 69(11), 3033-3040.
Cost of treating inpatient falciparum malaria on the Thai-Myanmar border
Kyaw, S., Drake, T., Ruangveerayuth, R., Chierakul, W., White, N., Newton, P., & Lubell, Y. (2014). Malaria Journal, 13(1), 416.
Falsified medicines in Africa: all talk, no action
Newton, P., Tabernero, P., Dwivedi, P., Culzoni, M., Monge, M., Swamidoss, I., Mildenhall, D., Green, M., Jähnke, R., de Oliveira, M., Simao, J., White, N., & Fernández, F. (2014). Lancet Global Health, 2(9), e509 - e510.
Spread of artemisinin resistance in Plasmodium falciparum malaria.
Ashley, E., Dhorda, M., Fairhurst, R., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J., Mao, S., Sam, B., Sopha, C., Chuor, C., Nguon, C., Sovannaroth, S., Pukrittayakamee, S., Jittamala, P., Chotivanich, K., Chutasmit, K., Suchatsoonthorn, C., … Tracking Resistance to Artemisinin Collaboration (TRAC). (2014). The New England Journal of Medicine, 371(5), 411-423.
Benefits of a pharmacology antimalarial reference standard and proficiency testing program provided by the Worldwide Antimalarial Resistance Network (WWARN).
Lourens, C., Lindegardh, N., Barnes, K., Guerin, P., Sibley, C., White, N., & Tarning, J. (2014). Antimicrobial Agents and Chemotherapy, 58(7), 3889-3894.
Thiamin supplementation does not reduce the frequency of adverse events after anti-malarial therapy among patients with falciparum malaria in southern Laos.
Mayxay, M., Khanthavong, M., Cox, L., Sichanthongthip, O., Imwong, M., Pongvongsa, T., Hongvanthong, B., Phompida, S., Vanisaveth, V., White, N., & Newton, P. (2014). Malaria Journal, 13, 275.
Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries
Tanomsing, N., Mayxay, M., Newton, P., Nosten, F., Dolecek, C., Hien, T., White, N., Day, N., Dondorp, A., & Imwong, M. (2014). PLoS ONE, 9(4), e93942.
Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives
Flegg, J., Guérin, P., Nosten, F., Ashley, E., Phyo, A., Dondorp, A., Fairhurst, R., Socheat, D., Borrmann, S., Björkman, A., Mårtensson, A., Mayxay, M., Newton, P., Bethell, D., Se, Y., Noedl, H., Diakite, M., Djimde, A., Hien, T., … Stepniewska, K. (2013). Malaria Journal, 12.
Population Pharmacokinetics of Lumefantrine in Pregnant and Nonpregnant Women With Uncomplicated Plasmodium falciparum Malaria in Uganda.
Kloprogge, F., Piola, P., Dhorda, M., Muwanga, S., Turyakira, E., Apinan, S., Lindegårdh, N., Nosten, F., Day, N., White, N., Guerin, P., & Tarning, J. (2013). CPT Pharmacometrics Syst Pharmacol, 2(11), e83.
Pharmacokinetic properties of artemether, dihydroartemisinin, lumefantrine, and quinine in pregnant women with uncomplicated plasmodium falciparum malaria in Uganda.
Tarning, J., Kloprogge, F., Dhorda, M., Jullien, V., Nosten, F., White, N., Guerin, P., & Piola, P. (2013). Antimicrob Agents Chemother, 57(10), 5096-5103.
Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand.
Newton, P., Stepniewska, K., Dondorp, A., Silamut, K., Chierakul, W., Krishna, S., Davis, T., Suputtamongkol, Y., Angus, B., Pukrittayakamee, S., Ruangveerayuth, R., Hanson, J., Day, N., & White, N. (2013). Malar J, 12(1).
A major genome region underlying artemisinin resistance in malaria.
Cheeseman, I., Miller, B., Nair, S., Nkhoma, S., Tan, A., Tan, J., Al Saai, S., Phyo, A., Moo, C., Lwin, K., McGready, R., Ashley, E., Imwong, M., Stepniewska, K., Yi, P., Dondorp, A., Mayxay, M., Newton, P., White, N., … Anderson, T. (2012). Science, 336(6077), 79-82.
No evidence for spread of Plasmodium falciparum artemisinin resistance to Savannakhet Province, Southern Laos.
Mayxay, M., Khanthavong, M., Chanthongthip, O., Imwong, M., Lee, S., Stepniewska, K., Soonthornsata, B., Pongvongsa, T., Phompida, S., Hongvanthong, B., Ringwald, P., White, N., & Newton, P. (2012). Am J Trop Med Hyg, 86(3), 403-408.
Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
Tarning, J., Kloprogge, F., Piola, P., Dhorda, M., Muwanga, S., Turyakira, E., Nuengchamnong, N., Nosten, F., Day, N., White, N., Guerin, P., & Lindegardh, N. (2012). Malar J, 11(1).
Optimal sampling designs for accurate estimation of parasite clearance in the context of artemisinin resistance
Flegg, J., Guerin, P., Nosten, F., Dondorp, A., Fairhurst, R., Socheat, D., Borrmann, S., Björkman, A., Mårtensson, A., Mayxay, M., Newton, P., Bethell, D., Se, Y., Noedl, H., Djimde, A., White, N., & Stepniewska, K. (2012). Malaria Journal, 11(Suppl 1), P39 - P39.
Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern Laos.
Mayxay, M., Khanthavong, M., Chanthongthip, O., Imwong, M., Pongvongsa, T., Hongvanthong, B., Phompida, S., Vanisaveth, V., White, N., & Newton, P. (2012). Malar J, 11(1).
The primacy of public health considerations in defining poor quality medicines.
Newton, P., Amin, A., Bird, C., Passmore, P., Dukes, G., Tomson, G., Simons, B., Bate, R., Guerin, P., & White, N. (2011). PLoS Medicine, 8(12).
Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi
Soukaloun, D., Lee, S., Chamberlain, K., Taylor, A., Mayxay, M., Sisouk, K., Soumphonphakdy, B., Latsavong, K., Akkhavong, K., Phommachanh, D., Sengmeuang, V., Luangxay, K., McDonagh, T., White, N., & Newton, P. (2011). PLoS Neglected Tropical Diseases, 5(2), ARTN e971.
Clinically unapparent infantile thiamin deficiency in Vientiane, Laos
Khounnorath, S., Chamberlain, K., Taylor, A., Soukaloun, D., Mayxay, M., Lee, S., Phengdy, B., Luangxay, K., Sisouk, K., Soumphonphakdy, B., Latsavong, K., Akkhavong, K., White, N., & Newton, P. (2011). PLoS Neglected Tropical Diseases, 5(2), ARTN e969.
Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator.
Flegg, J., Guerin, P., White, N., & Stepniewska, K. (2011). Malaria Journal, 10(1), 339.
Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription.
Mok, S., Imwong, M., Mackinnon, M., Sim, J., Ramadoss, R., Yi, P., Mayxay, M., Chotivanich, K., Liong, K., Russell, B., Socheat, D., Newton, P., Day, N., White, N., Preiser, P., Nosten, F., Dondorp, A., & Bozdech, Z. (2011). BMC Genomics, 12(1), 391.
Likely health outcomes for untreated acute febrile illness in the tropics in decision and economic models; a Delphi survey.
Lubell, Y., Staedke, S., Greenwood, B., Molyneux, M., Newton, P., Reyburn, H., Snow, R., D’Alessandro, U., English, M., Day, N., Kremsner, P., Dondorp, A., Mbacham, W., Dorsey, G., Owusu-Agyei, S., Maitland, K., Krishna, S., Newton, C., Pasvol, G., … Whitty, C. (2011). PloS One, 6(2).