Professor
Nicholas
White
Professor of Tropical Medicine
Nick White is a Professor of Tropical Medicine at Mahidol University Thailand and at the University of Oxford, and a consultant physician in acute general medicine at the John Radcliffe Hospital, Oxford, UK. He was Chair of the WWARN Board until 2016, and remains a member of the IDDO Board.
He also co-chaired the World Health Organization antimalarial treatment guidelines committee and the WHO Global Malaria Programme case management cluster. Prof White has served on the editorial advisory boards of international journals including The Lancet and PLoS Medicine. He has contributed to over 1000 peer reviewed scientific publications and has written over 50 book chapters.
Nick White began his work in Thailand in 1980 with the Wellcome Trust Mahidol Oxford Tropical Medicine Research Unit, a collaborative research programme between Mahidol and Oxford Universities. In 1986 he was appointed as Director of the Thailand Unit, and more recently Chair of the Wellcome Trust SE Asian Tropical Medicine Research Programmes.
Nick White’s contribution to tropical medicine and global health was recognised with a UK Knighthood in 2017. His research interests include the epidemiology, pathophysiology and treatment of malaria, melioidosis, typhoid, leptospirosis, dengue, haemorrhagic fever, Japanese encephalitis and tuberculosis.
All Publications
Guidelines should not pool evidence from uncomplicated and severe COVID-19
White, N., Strub-Wourgaft, N., Faiz, A., & Guerin, P. (2021). Lancet, 397(10281), 1262-1263.
A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?
Jittamala, P., Monteiro, W., Smit, M., Pedrique, B., Specht, S., Chaccour, C., Dard, C., Del Giudice, P., Khieu, V., Maruani, A., Failoc-Rojas, V., Sáez-de-Ocariz, M., Soriano-Arandes, A., Piquero-Casals, J., Faisant, A., Brenier-Pinchart, M.-P., Wimmersberger, D., Coulibaly, J., Keiser, J., … Kobylinski, K. (2021). PLOS Neglected Tropical Diseases, 15(3).
Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria
Awab, G., Aaram, F., Jamornthanyawat, N., Suwannasin, K., Pagornrat, W., Watson, J., Woodrow, C., Dondorp, A., Day, N., Imwong, M., & White, N. (2021). ELife, 10.
Electrocardiographic effects of four antimalarials for pregnant women with uncomplicated malaria on the Thailand-Myanmar border: A randomised controlled trial
Saito, M., Yotyingaphiram, W., Cargill, Z., Gilder, M., Min, A., Phyo, A., San, T., Poe, H., Chu, C., White, N., Nosten, F., & McGready, R. (2021). Antimicrobial Agents and Chemotherapy, 65(4).
Optimal design for phase 2 studies of SARS-CoV-2 antiviral drugs
Watson, J., Kissler, S., Day, N., Grad, Y., & White, N. (2021).
Improving the diagnosis of severe malaria in African children using platelet counts and plasma Pf HRP2 concentrations
Watson, J., Uyoga, S., Wanjiku, P., Makale, J., Nyutu, G., Mturi, N., George, E., Woodrow, C., Day, N., Bejon, P., Opoka, R., Dondorp, A., John, C., Maitland, K., Williams, T., & White, N. (2021). In medRxiv.
The prognostic and diagnostic value of intraleukocytic malaria pigment: an individual patient data pooled meta-analysis of 32,000 patients with severe falciparum malaria in Africa and Asia
Srinamon, K., Watson, J., Silamut, K., Intharabut, B., Phu, N., Diep, P., Lyke, K., Fanello, C., Seidlein, L., Chotivanich, K., Dondorp, A., Day, N., & White, N. (2021). In medRxiv.
Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
White, N., Watson, J., & Baird, K. (2021). In Authorea Preprints.
The WHO guideline on drugs to prevent COVID-19: small numbers- big conclusions.
Schilling, W., Callery, J., Chandna, A., Hamers, R., Watson, J., & White, N. (2021). Wellcome Open Research, 6, 71.
Time-to-death is a potential confounder in observational studies of blood transfusion in severe malaria.
Watson, J., Leopold, S., Dondorp, A., & White, N. (2021). The Lancet. Haematology, 8(1), e12.
The WHO guideline on drugs to prevent COVID-19: small numbers- big conclusions.
Schilling, W., Callery, J., Chandna, A., Hamers, R., Watson, J., & White, N. (2021). Wellcome Open Research, 6, 71.
Questioning the claimed superiority of malaria parasite ex vivo viability reduction over observed parasite clearance rate?
White, N., & Watson, J. (2020). The Journal of Infectious Diseases, 224(4), 738-739.
Is malaria parasite ex-vivo viability reduction really "superior" to observed parasite clearance rate?
White, N., & Watson, J. (2020). The Journal of Infectious Diseases.
The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network
Hossain, M., Commons, R., Douglas, N., Thriemer, K., Alemayehu, B., Amaratunga, C., Anvikar, A., Ashley, E., Asih, P., Carrara, V., Lon, C., D’Alessandro, U., Davis, T., Dondorp, A., Edstein, M., Fairhurst, R., Ferreira, M., Hwang, J., Janssens, B., … Price, R. (2020). PLOS Medicine, 17(11).
Chloroquine/ hydroxychloroquine prevention of coronavirus disease (COVID-19) in the healthcare setting; protocol for a randomised, placebo-controlled prophylaxis study (COPCOV)
Schilling, W., Callery, J., Taylor, W., Mukaka, M., Ekkapongpisit, M., Watson, J., Chandna, A., Panapipat, S., Tubprasert, J., Yuentrakul, P., Waithira, N., Cope, T., Dhorda, M., Cruz, C., von Seidlein, L., Milton, J., LLewelyn, M., Adler, A., Chotivanich, K., … White, N. (2020). Wellcome Open Research, 5, 241-241.
A cautionary note on the use of unsupervised machine learning algorithms to characterise malaria parasite population structure from genetic distance matrices
Watson, J., Taylor, A., Ashley, E., Dondorp, A., Buckee, C., White, N., & Holmes, C. (2020). PLoS Genetics, 16(10).
Effect of hydroxychloroquine in hospitalized patients with COVID-19
Horby, P., Mafham, M., Linsell, L., Bell, J., Staplin, N., Emberson, J., Tarning, J., Watson, J., White, N., Juszczak, E., Haynes, R., & Landray, M. (2020). New England Journal of Medicine, 383(21), 2030-2040.
COVID-19 prevention and treatment: A critical analysis of chloroquine and hydroxychloroquine clinical pharmacology
White, N., Watson, J., Hoglund, R., Chan, X., Cheah, P., & Tarning, J. (2020). PLOS Medicine, 17(9).
Concentration-dependent mortality of chloroquine in overdose
Watson, J., Tarning, J., Hoglund, M., Baud, F., Megarbane, B., Clemessy, J.-L., & White, N. (2020). ELife, 9.
Non-adherence in non-inferiority trials: pitfalls and recommendations
Mo, Y., Lim, C., Watson, J., White, N., & Cooper, B. (2020). BMJ, 370.
Estimating the proportion of plasmodium vivax recurrences caused by relapse: A systematic review and meta-analysis
Commons, R., Simpson, J., Watson, J., White, N., & Price, R. (2020). American Journal of Tropical Medicine and Hygiene.
Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Saito, M., Mansoor, R., Kennon, K., Anvikar, A., Ashley, E., Chandramohan, D., Cohee, L., D’Alessandro, U., Genton, B., Gilder, M., Juma, E., Kalilani-Phiri, L., Kuepfer, I., Laufer, M., Lwin, K., Meshnick, S., Mosha, D., Muehlenbachs, A., Mwapasa, V., … Guérin, P. (2020). BMC Medicine, 18(1).
A cautionary note on the use of unsupervised machine learning algorithms to characterise malaria parasite population structure from genetic distance matrices
Watson, J., Taylor, A., Ashley, E., Dondorp, A., Buckee, C., White, N., & Holmes, C. (2020).
Concomitant bacteremia in adults with severe falciparum malaria
Phu, N., Day, N., Tuan, P., Mai, N., Chau, T., Van Chuong, L., Vinh, H., Loc, P., Sinh, D., Hoa, N., Waller, D., Wain, J., Jeyapant, A., Watson, J., Farrar, J., Hien, T., Parry, C., & White, N. (2020). Clinical Infectious Diseases, 71(9), e465 - e470.
Mass drug administrations with dihydroartemisinin-piperaquine and single low dose primaquine to eliminate Plasmodium falciparum have only a transient impact on Plasmodium vivax: Findings from randomised controlled trials
Phommasone, K., van Leth, F., Peto, T., Landier, J., Nguyen, T.-N., Tripura, R., Pongvongsa, T., Lwin, K., Kajeechiwa, L., Thwin, M., Parker, D., Wiladphaingern, J., Nosten, S., Proux, S., Nguon, C., Davoeung, C., Rekol, H., Adhikari, B., Promnarate, C., … von Seidlein, L. (2020). PLoS ONE, 15(2).