Professor
Nicholas
White
Professor of Tropical Medicine
Nick White is a Professor of Tropical Medicine at Mahidol University Thailand and at the University of Oxford, and a consultant physician in acute general medicine at the John Radcliffe Hospital, Oxford, UK. He was Chair of the WWARN Board until 2016, and remains a member of the IDDO Board.
He also co-chaired the World Health Organization antimalarial treatment guidelines committee and the WHO Global Malaria Programme case management cluster. Prof White has served on the editorial advisory boards of international journals including The Lancet and PLoS Medicine. He has contributed to over 1000 peer reviewed scientific publications and has written over 50 book chapters.
Nick White began his work in Thailand in 1980 with the Wellcome Trust Mahidol Oxford Tropical Medicine Research Unit, a collaborative research programme between Mahidol and Oxford Universities. In 1986 he was appointed as Director of the Thailand Unit, and more recently Chair of the Wellcome Trust SE Asian Tropical Medicine Research Programmes.
Nick White’s contribution to tropical medicine and global health was recognised with a UK Knighthood in 2017. His research interests include the epidemiology, pathophysiology and treatment of malaria, melioidosis, typhoid, leptospirosis, dengue, haemorrhagic fever, Japanese encephalitis and tuberculosis.
All Publications
Correction to: The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR.
Phommasone, K., van Leth, F., Imwong, M., Henriques, G., Pongvongsa, T., Adhikari, B., Peto, T., Promnarate, C., Dhorda, M., Sirithiranont, P., Mukaka, M., Peerawaranun, P., Day, N., Cobelens, F., Dondorp, A., Newton, P., White, N., von Seidlein, L., & Mayxay, M. (2020). Malaria Journal, 19(1), 32.
The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR
Phommasone, K., Van Leth, F., Imwong, M., Henriques, G., Pongvongsa, T., Adhikari, B., Peto, T., Promnarate, C., Dorda, M., Sirithiranont, P., Mukaka, M., Peerawaranun, P., Day, N., Cobelens, F., Dondorp, A., Newton, P., White, N., Von Seidlein, L., & Mayxay, M. (2020). Malaria Journal, 19.
Concentration-dependent mortality of chloroquine in overdose
Watson, J., Tarning, J., Hoglund, R., Baud, F., Mégarbane, B., Clemessy, J.-L., & White, N. (2020).
Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial
Horby, P., Mafham, M., Linsell, L., Bell, J., Staplin, N., Emberson, J., Wiselka, M., Ustianowski, A., Elmahi, E., Prudon, B., Whitehouse, A., Felton, T., Williams, J., Faccenda, J., Underwood, J., Baillie, K., Chappell, L., Faust, S., Jaki, T., … Landray, M. (2020).
Resolving the cause of recurrent Plasmodium vivax malaria probabilistically
Taylor, A., Watson, J., Chu, C., Puaprasert, K., Duanguppama, J., Day, N., Nosten, F., Neafsey, D., Buckee, C., Imwong, M., & White, N. (2019). Nature Communications, 10(1).
Efficacy and tolerability of artemisinin- and quenine-based treatments for uncomplicated falciparum malaria during pregnanc: A WWARN individual patient data meta-analysis
Saito, M., Mansoor, R., Kennon, K., Anvikar, A., Ashley, E., Chandramohan, D., Cohee, L., D’Alessandro, U., Genton, B., Juma, E., Kalilani-Phiri, L., Kuepfer, I., Laufer, M., Lwin, K., Meshnick, S., Mosha, D., Mwapasa, V., Mwebaza, N., Nambozi, M., … Guerin, P. (2019). American Journal of Tropical Medicine and Hygiene, 101(S5), 81.
The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: a systematic review and individual patient data meta-analysis
Commons, R., Simpson, J., Thriemer, K., Abreha, T., Adam, I., Anstey, N., Assefa, A., Awab, G., Baird, J., Barber, B., Chu, C., Dahal, P., Daher, A., Davis, T., Dondorp, A., Grigg, M., Humphreys, G., Hwang, J., Karunajeewa, H., … Price, R. (2019). PLOS Medicine, 16(10).
Investigating causal pathways in severe falciparum malaria: A pooled retrospective analysis of clinical studies.
Leopold, S., Watson, J., Jeeyapant, A., Simpson, J., Phu, N., Hien, T., Day, N., Dondorp, A., & White, N. (2019). PLoS Medicine, 16(8).
Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns
Shetty, A., Jacob, C., Huang, F., Li, Y., Agrawal, S., Saunders, D., Lon, C., Fukuda, M., Ringwald, P., Ashley, E., Han, K., Hlaing, T., Nyunt, M., Silva, J., Stewart, K., Plowe, C., O’Connor, T., Takala-Harrison, S., & White, N. (2019). Nature Communications, 10.
Optimal duration of follow-up for assessing antimalarial efficacy in pregnancy: a retrospective analysis of a cohort followed up until delivery on the Thailand-Myanmar border
Saito, M., Mansoor, R., Wiladphaingern, J., Paw, M., Pimanpanarak, M., Proux, S., Guérin, P., White, N., Nosten, F., & McGready, R. (2019). Open Forum Infectious Diseases, 6(7).
Treatment-seeking behaviour for febrile illnesses and its implications for malaria control and elimination in Savannakhet Province, Lao PDR (Laos): a mixed method study
Adhikari, B., Phommasone, K., Pongvongsa, T., Koummarasy, P., Soundala, X., Henriques, G., Sirithiranont, P., Parker, D., Von Seidlein, L., White, N., Day, N., Dondorp, A., Newton, P., Cheah, P., Pell, C., & Mayxay, M. (2019). BMC Health Services Research, 19.
Pharmacokinetic-pharmacodynamic assessment of the hepatic and bone-marrow toxicities of the new trypanoside fexinidazole
Watson, J., Strub-Wourgraft, N., Tarral, A., Ribeiro, I., Tarning, J., & White, N. (2019). Antimicrobial Agents and Chemotherapy, 63(4), e02515 - 18.
Collider bias and the apparent protective effect of glucose-6-phosphate dehydrogenase deficiency on cerebral malaria
Watson, J., Leopold, S., Simpson, J., Day, N., Dondorp, A., & White, N. (2019). ELife, 8.
Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis
Ashley, E., Dhorda, M., Dondorp, A., Fanello, C., Guérin, P., Humphreys, G., Kennon, K., Mayxay, M., Nosten, F., Phyo, A., Sibley, C., Sondo, P., Stepniewska, K., White, N., & Woodrow, C. (2019). BMC Medicine, 1(17).
Estimating the probable cause of recurrence in Plasmodium vivax malaria: relapse, reinfection or recrudescence?
Taylor, A., Watson, J., Chu, C., Puaprasert, K., Duanguppama, J., Day, N., Nosten, F., Neafsey, D., Buckee, C., Imwong, M., & White, N. (2018).
Perceptions of asymptomatic malaria infection and their implications for malaria control and elimination in Laos
Adhikari, B., Phommasone, K., Pongvongsa, T., Soundala, X., Koummarasy, P., Henriques, G., Peto, T., Seidlein, L., White, N., Day, N., Dondorp, A., Newton, P., Cheah, P., Mayxay, M., & Pell, C. (2018). PloS One, 13(12), e0208912.
A pharmacokinetic-pharmacodynamic assessment of the hepatic and bone-marrow toxicities of the new trypanoside fexinidazole
Watson, J., Strub-Wourgraft, N., Tarral, A., Ribeiro, I., Tarning, J., & White, N. (2018).
The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
Zhu, L., Tripathi, J., Rocamora, F., Miotto, O., Van Der Pluijm, R., Voss, T., Mok, S., Kwiatkowski, D., Nosten, F., Day, N., White, N., Dondorp, A., & Bozdech, Z. (2018). Nature Communications, 9.
The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review
Haeusler, I., Chan, X., Guérin, P., & White, N. (2018). BMC Medicine, 16(200), 1-13.
The dynamic of asymptomatic Plasmodium falciparum infections following mass drug administrations with dihydroarteminisin-piperaquine plus a single low dose of primaquine in Savannakhet Province, Laos
Pongvongsa, T., Phommasone, K., Adhikari, B., Henriques, G., Chotivanich, K., Hanboonkunupakarn, B., Mukaka, M., Peerawaranun, P., Von Seidlein, L., Day, N., White, N., Dondorp, A., Imwong, M., Newton, P., Singhasivanon, P., Mayxay, M., & Pukrittayakamee, S. (2018). Malaria Journal, 17(1), 405.
Chloroquine versus hihydroartemisinin-piperaquine with standard high-dose Primaquine given either for 7 days or 14 days in Plasmodium vivax malaria
Chu, C., Phyo, A., Turner, C., Win, H., Poe, N., Yotyingaphiram, W., Thinraow, S., Wilairisak, P., Raksapraidee, R., Carrara, V., Paw, M., Wiladphaingern, J., Proux, S., Bancone, G., Sriprawat, K., Lee, S., Jeeyapant, A., Watson, J., Tarning, J., … White, N. (2018). Clinical Infectious Diseases, 68(8), 1311-1319.
Genetic polymorphisms in the circumsporozoite protein of Plasmodium malariae show a geographical bias
Saralamba, N., Mayxay, M., Newton, P., Smithuis, F., Nosten, F., Archasuksan, L., Pukrittayakamee, S., White, N., Day, N., Dondorp, A., & Imwong, M. (2018). Malaria Journal, 17(1), 269.
Comparison of glucose-6 phosphate dehydrogenase status by fluorescent spot test and rapid diagnostic test in Lao PDR and Cambodia
Henriques, G., Phommasone, K., Tripura, R., Peto, T., Raut, S., Snethlage, C., Sambo, I., Sanann, N., Nguon, C., Adhikari, B., Pongvongsa, T., Imwong, M., von Seidlein, L., Day, N., White, N., Dondorp, A., Newton, P., Ley, B., & Mayxay, M. (2018). Malaria Journal, 17(1), 1.
Comparison of the cumulative efficacy and safety of chloroquine, artesunate, and chloroquine-primaquine in plasmodium vivax malaria
Chu, C., Phyo, A., Lwin, K., Win, H., San, T., Aung, A., Raksapraidee, R., Carrara, V., Bancone, G., Watson, J., Moore, K., Wiladphaingern, J., Proux, S., Sriprawat, K., Winterberg, M., Cheah, P., Chue, A., Tarning, J., Imwong, M., … White, N. (2018). Clinical Infectious Diseases, 67(10), 1543-1549.
Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis
Kloprogge, F., Newton, P., Mayxay, M., Nosten, F., Ashley, E., McGready, R., van Vugt, V., Proux, S., Price, R., Stepniewska, K., White, N., Guerin, P., & Tarning, J. (2018). PLoS Medicine.