Professor
Nicholas
White
Professor of Tropical Medicine
Nick White is a Professor of Tropical Medicine at Mahidol University Thailand and at the University of Oxford, and a consultant physician in acute general medicine at the John Radcliffe Hospital, Oxford, UK. He was Chair of the WWARN Board until 2016, and remains a member of the IDDO Board.
He also co-chaired the World Health Organization antimalarial treatment guidelines committee and the WHO Global Malaria Programme case management cluster. Prof White has served on the editorial advisory boards of international journals including The Lancet and PLoS Medicine. He has contributed to over 1000 peer reviewed scientific publications and has written over 50 book chapters.
Nick White began his work in Thailand in 1980 with the Wellcome Trust Mahidol Oxford Tropical Medicine Research Unit, a collaborative research programme between Mahidol and Oxford Universities. In 1986 he was appointed as Director of the Thailand Unit, and more recently Chair of the Wellcome Trust SE Asian Tropical Medicine Research Programmes.
Nick White’s contribution to tropical medicine and global health was recognised with a UK Knighthood in 2017. His research interests include the epidemiology, pathophysiology and treatment of malaria, melioidosis, typhoid, leptospirosis, dengue, haemorrhagic fever, Japanese encephalitis and tuberculosis.
All Publications
The impact of malaria-protective red blood cell polymorphisms on parasite biomass in children with severe Plasmodium falciparum malaria
Uyoga, S., Watson, J., Wanjiku, P., Rop, J., Makale, J., Macharia, A., Kariuki, S., Nyutu, G., Shebe, M., Mosobo, M., Mturi, N., Rockett, K., Woodrow, C., Dondorp, A., Maitland, K., White, N., & Williams, T. (2022). Nature Communications, 13(1).
Pharmacometric and electrocardiographic evaluation of chloroquine and azithromycin in healthy volunteers
Chotsiri, P., Tarning, J., Hoglund, R., Watson, J., & White, N. (2022). Clinical Pharmacology & Therapeutics, 112(4), 824-835.
Cooperation in countering artemisinin resistance in Africa: learning from COVID-19
Rosenthal, P., Björkman, A., Dhorda, M., Djimde, A., Dondorp, A., Gaye, O., Guerin, P., Juma, E., Kwiatkowski, D., Merson, L., Ntoumi, F., Price, R., Raman, J., Roos, D., Ter Kuile, F., Tinto, H., Tomko, S., White, N., & Barnes, K. (2022). American Journal of Tropical Medicine and Hygiene, 106(6), 1568-1570.
Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
Zhu, L., van der Pluijm, R., Kucharski, M., Nayak, S., Tripathi, J., White, N., Day, N., Faiz, A., Phyo, A., Amaratunga, C., Lek, D., Ashley, E., Nosten, F., Smithuis, F., Ginsburg, H., von Seidlein, L., Lin, K., Imwong, M., Chotivanich, K., … Bozdech, Z. (2022). Communications Biology, 5.
Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
White, N., Watson, J., & Baird, J. (2022). British Journal of Clinical Pharmacology, 88(6), 2657-2664.
The fragmented COVID-19 therapeutics research landscape: a living systematic review of clinical trial registrations evaluating priority pharmacological interventions
McLean, A., Rashan, S., Tran, L., Arena, L., Lawal, A., Maguire, B., Adele, S., Antonio, E., Brack, M., Caldwell, F., Carrara, V., Charles, R., Citarella, B., Epie, T., Feteh, V., Kennon, K., Makuka, G., Ngu, R., Nwosu, A.-P., … Guérin, P. (2022). In Wellcome Open Research.
Pharmacometric assessment of the in vivo antiviral activity of ivermectin in early symptomatic COVID-19
Schilling, W., Jittamala, P., Watson, J., Ekkapongpisit, M., Siripoon, T., Ngamprasertchai, T., Luvira, V., Pongwilai, S., Cruz, C., Callery, J., Boyd, S., Kruabkontho, V., Ngernseng, T., Tubprasert, J., Abdad, M., Piaraksa, N., Suwannasin, K., Hanboonkunupakarn, P., Hanboonkunupakarn, B., … White, N. (2022). In medRxiv.
The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: an individual patient data meta-analysis
Watson, J., Commons, R., Tarning, J., Simpson, J., Cuentas, A., Lacerda, M., Green, J., Koh, G., Chu, C., H Nosten, F., Price, R., Day, N., & White, N. (2022). In medRxiv.
The impact of malaria-protective red blood cell polymorphisms on parasite biomass in children with severe Plasmodium falciparum malaria
Uyoga, S., Watson, J., Wanjiku, P., Rop, J., Makale, J., Macharia, A., Kariuki, S., Nyutu, G., Shebe, M., Mosobo, M., Mturi, N., Rockett, K., Woodrow, C., Dondorp, A., Maitland, K., White, N., & Williams, T. (2022). In medRxiv.
Asexual stage synchronicity in symptomatic and asymptomatic falciparum malaria
Watson, J., & White, N. (2022). In medRxiv.
Clinical antiviral efficacy of remdesivir and casirivimab/imdevimab against the SARS-CoV-2 Delta and Omicron variants
Jittamala, P., Schilling, W., Watson, J., Luvira, V., Siripoon, T., Ngamprasertchai, T., Almeida, P., Ekkapongpisit, M., Cruz, C., Callery, J., Boyd, S., Anunsittichai, O., Hongsuwan, M., Singhaboot, Y., Pagornrat, W., Tuntipaiboontana, R., Kruabkontho, V., Ngernseng, T., Tubprasert, J., … White, N. (2022). In medRxiv.
Severe malaria, pascalian therapeutics, and the US Food and Drug Administration (FDA)
White, N., Watson, J., & Simpson, J. (2022). Clinical Infectious Diseases, 75(2), 358-358.
Falciparum malaria mortality in sub-Saharan Africa in the pretreatment era
Watson, J., White, N., & Dondorp, A. (2021). Trends in Parasitology, 38(1), 11-14.
Evolution of multidrug resistance in Plasmodium falciparum: A longitudinal study of genetic resistance markers in the Greater Mekong subregion
Imwong, M., Suwannasin, K., Srisutham, S., Vongpromek, R., Promnarate, C., Saejeng, A., Phyo, A., Proux, S., Pongvongsa, T., Chea, N., Miotto, O., Tripura, R., Nguyen Hoang, C., Dysoley, L., Ho Dang Trung, N., Peto, T., Callery, J., van der Pluijm, R., Amaratunga, C., … Dondorp, A. (2021). Antimicrobial Agents and Chemotherapy, 65(12).
The WHO guideline on drugs to prevent COVID-19: small numbers- big conclusions
Schilling, W., Callery, J., Chandna, A., Hamers, R., Watson, J., & White, N. (2021). Wellcome Open Research, 6, 71-71.
Clustering of malaria in households in the Greater Mekong Subregion: operational implications for reactive case detection
Mukaka, M., Peerawaranun, P., Parker, D., Kajeechiwa, L., Nosten, F., Nguyen, T.-N., Hien, T., Tripura, R., Peto, T., Phommasone, K., Mayxay, M., Newton, P., Imwong, M., Day, N., Dondorp, A., White, N., & von Seidlein, L. (2021). Malaria Journal, 20.
Determinants of primaquine and carboxyprimaquine exposures in children and adults with Plasmodium vivax malaria
Chu, C., Watson, J., Phyo, A., Win, H., Yotyingaphiram, W., Thinraow, S., Soe, N., Aung, A., Wilaisrisak, P., Kraft, K., Imwong, M., Hanpithakpong, W., Blessborn, D., Tarning, J., Proux, S., Ling, C., Nosten, F., & White, N. (2021). Antimicrobial Agents and Chemotherapy, 65(11).
WHO COVID-19 therapeutic guidelines – authors' reply
White, N., Strub-Wourgaft, N., Faiz, A., & Guerin, P. (2021). Lancet, 398(10295), 118-118.
Determinants of primaquine and carboxyprimaquine exposures in children and adults with Plasmodium vivax malaria
Chu, C., Watson, J., Phyo, A., Win, H., Yotyingaphiram, W., Thinraow, S., Soe, N., Aung, A., Wilaisrisak, P., Puaprasert, K., Imwong, M., Hanpithakpong, W., Blessborn, D., Tarning, J., Proux, S., Ling, C., Nosten, F., & White, N. (2021). In medRxiv.
Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision.
Watson, J., Ndila, C., Uyoga, S., Macharia, A., Nyutu, G., Mohammed, S., Ngetsa, C., Mturi, N., Peshu, N., Tsofa, B., Rockett, K., Leopold, S., Kingston, H., George, E., Maitland, K., Day, N., Dondorp, A., Bejon, P., Williams, T., … White, N. (2021). ELife, 10.
Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision
Watson, J., Ndila, C., Uyoga, S., Macharia, A., Nyutu, G., Shebe, M., Ngetsa, C., Mturi, N., Peshu, N., Tsofa, B., Rockett, K., Leopold, S., Kingston, H., George, E., Maitland, K., Day, N., Dondorp, A., Bejon, P., Williams, T., … White, N. (2021). ELife, 10.
Definitions matter: heterogeneity of COVID-19 disease severity criteria and incomplete reporting compromise meta-analysis
Guérin, P., McLean, A., Rashan, S., Lawal, A., Watson, J., Strub-Wourgaft, N., & White, N. (2021).
A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border.
Saito, M., Carrara, V., Gilder, M., Min, A., Tun, N., Pimanpanarak, M., Viladpai-Nguen, J., Paw, M., Haohankhunnatham, W., Konghahong, K., Phyo, A., Chu, C., Turner, C., Lee, S., Duanguppama, J., Imwong, M., Bancone, G., Proux, S., Singhasivanon, P., … McGready, R. (2021). BMC Medicine, 19(1).
The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response
Zhu, L., Pluijm, R., Kucharski, M., Nayak, S., Tripathi, J., Nosten, F., Faiz, A., Amaratunga, C., Lek, D., Ashley, E., Smithuis, F., Phyo, A., Lin, K., Imwong, M., Mayxay, M., Dhorda, M., Chau, N., Thuy, N., Newton, P., … Bozdech, Z. (2021).
The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response
Zhu, L., van der Pluijm, R., Kucharski, M., Nayak, S., Tripathi, J., Nosten, F., Faiz, A., Amaratunga, C., Lek, D., Ashley, E., Smithuis, F., Phyo, A., Lin, K., Imwong, M., Mayxay, M., Dhorda, M., Chau, N., Thuy, N., Newton, P., … Bozdech, Z. (2021).