Professor
Philippe
Guérin
Membre - Comité de pilotage sur le virus Ebola (Ebola SC)
L'Université d’Oxford
Après avoir travaillé comme médecin en France et au Népal, Philippe a rejoint Médecins Sans Frontières où il a acquis une vaste expérience en tant que chercheur travaillant sur le terrain et sur le paludisme et la tuberculose. Il a été pendant six ans directeur scientifique d'Epicentre à Paris, un centre collaborateur de l'Organisation mondiale de la santé pour la recherche en épidémiologie et la réponse aux maladies émergentes. Auparavant, il a été conseiller principal à l'Institut norvégien de santé publique pendant trois ans.
Philippe est directeur de l'Observatoire de données sur les maladies infectieuses (IDDO), dont la mission est de rassembler et d'agréger des données cliniques, laboratoire et épidémiologiques sur certaines maladies sélectionnées liées à la pauvreté et sur les infections émergentes. IDDO s’appuie sur le succès du réseau WWARN (WorldWide Antimalarial Resistance Network), une plateforme scientifiquement indépendante et multidisciplinaire, créée en 2009 pour fournir les informations nécessaires pour empêcher ou alléger la résistance aux médicaments antipaludiques et de cette manière réduire la mortalité, et la morbidité du paludisme.
Key Publications
High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.
Woodrow, C., Dahlström, S., Cooksey, R., Flegg, J., Le Nagard, H., Mentré, F., Murillo, C., Ménard, D., Nosten, F., Sriprawat, K., Musset, L., Quashie, N., Lim, P., Fairhurst, R., Nsobya, S., Sinou, V., Noedl, H., Pradines, B., Johnson, J., … Le Bras, J. (2013). Antimicrobial Agents and Chemotherapy, 57(7), 3121-3130.
Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority trial.
Schramm, B., Valeh, P., Baudin, E., Mazinda, C., Smith, R., Pinoges, L., Dhorda, M., Boum, Y., Sundaygar, T., Zolia, Y., Jones, J., Comte, E., Houzé, P., Jullien, V., Carn, G., Ashley, E., & Guérin, P. (2013). Malar J, 12(1).
Tolerability and safety of artesunate-amodiaquine and artemether-lumefantrine fixed dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria: two open-label, randomized trials in Nimba County, Liberia.
Schramm, B., Valeh, P., Baudin, E., Mazinda, C., Smith, R., Pinoges, L., Sundaygar, T., Zolia, Y., Jones, J., Comte, E., Bruneel, A., Branger, M., Jullien, V., Carn, G., Kiechel, Ashley, E., & Guérin, P. (2013). Malar J, 12(1).
Spatiotemporal mathematical modelling of mutations of the dhps gene in African Plasmodium falciparum.
Flegg, J., Patil, A., Venkatesan, M., Roper, C., Naidoo, I., Hay, S., Sibley, C., & Guerin, P. (2013). Malar J, 12(1).
All Publications
Effect of adherence to primaquine on the risk of Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Mehdipour, P., Rajasekhar, M., Dini, S., Zaloumis, S., Abreha, T., Adam, I., Awab, G., Baird, J., Brasil, L., Chu, C., Cui, L., Daher, A., do Socorro M Gomes, M., Gonzalez-Ceron, L., Hwang, J., Karunajeewa, H., Lacerda, M., Ladeia-Andrade, S., Leslie, T., … Commons, R. (2023). Malaria Journal, 22(1).
Enhanced effect of seasonal malaria chemoprevention when coupled with nutrients supplementation for preventing malaria in children under 5 years old in Burkina Faso: a randomized open label trial.
Sondo, P., Kaboré, B., Rouamba, T., Compaoré, E., Tibiri, Y., Kaboré, H.-E., Derra, K., Tahita, M., Ilboudo, H., Tougri, G., Bouda, I., Dakyo, T., Kafando, H., Ouédraogo, F., Rouamba, E., Hien, S.-V., Kazienga, A., Compaoré, C., Bambara, E., … Tinto, H. (2023). Malaria Journal, 22(1), 315.
Host, parasite and drug determinants of clinical outcomes following treatment of visceral leishmaniasis: a protocol for individual participant data meta-analysis.
Kumar, R., Dahal, P., Singh-Phulgenda, S., Siddiqui, N., Munir, A., Naylor, C., Wilson, J., Buck, G., Rahi, M., Malaviya, P., Alves, F., Sundar, S., Ritmeijer, K., Stepniewska, K., Guérin, P., & Pandey, K. (2023). BMJ Open, 13(10), e074679.
Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis
Commons, R., Rajasekhar, M., Edler, P., Abreha, T., Awab, G., Baird, J., Barber, B., Chu, C., Cui, L., Daher, A., Gonzalez-Ceron, L., Grigg, M., Hwang, J., Karunajeewa, H., Lacerda, M., Ladeia-Andrade, S., Lidia, K., Llanos-Cuentas, A., Longley, R., … Price, R. (2023). Lancet Infectious Diseases, 24(2), 172-183.
Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis
Rajasekhar, M., Simpson, J., Ley, B., Edler, P., Chu, C., Abreha, T., Awab, G., Baird, J., Bancone, G., Barber, B., Grigg, M., Hwang, J., Karunajeewa, H., Lacerda, M., Ladeia-Andrade, S., Llanos-Cuentas, A., Pukrittayakamee, S., Rijal, K., Saravu, K., … Price, R. (2023). Lancet Infectious Diseases, 24(2), 184-195.
Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial Resistance Network individual patient data meta-analysis
Price, R. (2023). Malaria Journal, 22(1).
Sudan Ebola virus (SUDV) outbreak in Uganda, 2022: lessons learnt and future priorities for sub-Saharan Africa
Bwire, G., Sartorius, B., Guerin, P., Tegegne, M., Okware, S., & Talisuna, A. (2023). BMC Medicine, 21(1).
A path to real-world evidence in critical care using open-source data harmonization tools
Heavner, S., Anderson, W., Kashyap, R., Dasher, P., Mathé, E., Merson, L., Guerin, P., Weaver, J., Robinson, M., Schito, M., Kumar, V., & Nagy, P. (2023). Critical Care Explorations, 5(4).
Correction: A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?
Jittamala, P., Monteiro, W., Smit, M., Pedrique, B., Specht, S., Chaccour, C., Dard, C., Giudice, P., Khieu, V., Maruani, A., Failoc-Rojas, V., Sáez-de-Ocariz, M., Soriano-Arandes, A., Piquero-Casals, J., Faisant, A., Brenier-Pinchart, M.-P., Wimmersberger, D., Coulibaly, J., Keiser, J., … Kobylinski, K. (2023). PLoS Neglected Tropical Diseases, 17(1), e0011053.
Systematic review and geospatial modelling of molecular markers of resistance to artemisinins and sulfadoxine-pyrimethamine in Plasmodium falciparum in India
Nain, M., Dhorda, M., Flegg, J., Gupta, A., Harrison, L., Phulgenda, S., Otienoburu, S., Harriss, E., Bharti, P., Behera, B., Rahi, M., Guerin, P., & Sharma, A. (2023). TROPICAL MEDICINE & INTERNATIONAL HEALTH, 28, 211-212.
Blood transfusion in care of patients with Visceral Leishmaniasis: a review of practices in therapeutic efficacy studies
Dahal, P., Singh-Phulgenda, S., Wilson, J., Cota, G., Ritmeijer, K., Musa, A., Alves, F., Stepniewska, K., & Guerin, P. (2023). In medRxiv.
Lymphatic filariasis treatment studies: The case for an individual participant-level data platform
Uddin, A., Freitas, L., Khan, M., Halder, J., Singh-Phulgenda, S., Raja, D., Balakrishnan, V., Rahi, M., Harriss, E., Guerin, P., Basanez, M.-G., Kumar, A., Walker, M., & Srividya, A. (2023). TROPICAL MEDICINE & INTERNATIONAL HEALTH, 28, 202-202.
Ophthalmological complications in visceral leishmaniasis and post kala-azar dermal leishmaniasis: A systematic review of published literature
Singh-Phulgenda, S., Dahal, P., Kumar, R., Munir, A., Naylor, C., Rahi, M., Harriss, E., Siddiqui, N., Alves, F., Musa, A., Stepniewska, K., Sundar, S., Guerin, P., & Pandey, K. (2023). TROPICAL MEDICINE & INTERNATIONAL HEALTH, 28, 227-228.
Definitions matter: heterogeneity of COVID-19 disease severity criteria and incomplete reporting compromise meta- analysis (vol 2, e000561, 2022)
Guerin, P., McLean, A., Rashan, S., Lawal, A., Watson, J., & Strub-Wourgaft, N. (2023). PLOS GLOBAL PUBLIC HEALTH, 3(4).
Design, conduct, analysis, and reporting of therapeutic efficacy studies in Visceral Leishmaniasis: A systematic review of published reports, 2000-2021
Dahal, P., Singh-Phulgenda, S., Naylor, C., Brack, M., Chatterjee, M., Alves, F., Guerin, P., & Stepniewska, K. (2023). In medRxiv.
Post-kala-azar dermal leishmaniasis (PKDL) drug efficacy study landscape: a systematic scoping review of clinical trials and observational studies to assess the feasibility of establishing an individual participant-level data (IPD) platform
Singh-Phulgenda, S., Kumar, R., Dahal, P., Munir, A., Rashan, S., Chhajed, R., Naylor, C., Maguire, B., Siddiqui, N., Harriss, E., Rahi, M., Alves, F., Sundar, S., Stepniewska, K., Musa, A., Guerin, P., & Pandey, K. (2023). In medRxiv.
Characterisation of populations at risk of sub-optimal dosing of artemisinin-based combination therapy in Africa
Takyi, A., Carrara, V., Dahal, P., Przybylska, M., Harriss, E., Insaidoo, G., Barnes, K., Guerin, P., & Stepniewska, K. (2023). In medRxiv.
Host, parasite and drug determinants of treatment outcomes in visceral leishmaniasis: An individual patient data meta-analysis using the infectious diseases data observatory data platform
Dahal, P., Kumar, R., Singh-Phulgenda, S., Munir, A., Siddiqui, N., Buck, G., Naylor, C., Brack, M., Rahi, M., Malaviya, P., Wassuna, M., Chappuis, F., Ritmeijer, K., Costa, C., Romero, G., Syriopoulou, V., Musa, A., Alves, F., Stepniewska, K., … Pandey, K. (2023). TROPICAL MEDICINE & INTERNATIONAL HEALTH, 28, 192-193.
Haemoglobin dynamics following treatment of visceral leishmaniasis: An individual patient data metaanalysis using the infectious diseases data observatory data platform
Dahal, P., Munir, A., Kumar, R., Singh-Phulgenda, S., Siddiqui, N., Buck, G., Naylor, C., Brack, M., Rahi, M., Malaviya, P., Wassuna, M., Chappuis, F., Ritmeijer, K., Costa, C., Romero, G., Syriopoulou, V., Alves, F., Stepniewska, K., Sundar, S., … Guerin, P. (2023). TROPICAL MEDICINE & INTERNATIONAL HEALTH, 28, 178-179.
Pregnancy outcomes after first-trimester treatment with artemisinin derivatives versus non-artemisinin antimalarials: a systematic review and individual patient data meta-analysis
Saito, M., McGready, R., Tinto, H., Rouamba, T., Mosha, D., Rulisa, S., Kariuki, S., Desai, M., Manyando, C., Njunju, E., Sevene, E., Vala, A., Augusto, O., Clerk, C., Were, E., Mrema, S., Kisinza, W., Byamugisha, J., Kagawa, M., … Dellicour, S. (2022). The Lancet, 401(10371), 118-130.
Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data
Stepniewska, K., Allen, E., Humphreys, G., Poirot, E., Craig, E., Kennon, K., Yilma, D., Bousema, T., Guerin, P., White, N., Price, R., Raman, J., Martensson, A., Mwaiswelo, R., Bancone, G., Bastiaens, G., Bjorkman, A., Brown, J., D’Alessandro, U., … Chen, I. (2022). BMC Medicine, 20.
Spatiotemporal spread of Plasmodium falciparum mutations for resistance to sulfadoxine-pyrimethamine across Africa, 1990-2020.
Flegg, J., Humphreys, G., Montanez, B., Strickland, T., Jacome-Meza, Z., Barnes, K., Raman, J., Guerin, P., Hopkins Sibley, C., & Dahlström Otienoburu, S. (2022). PLoS Computational Biology, 18(8), e1010317.
Definitions matter: heterogeneity of COVID-19 disease severity criteria and incomplete reporting compromise meta-analysis
Guérin, P., McLean, A., Rashan, S., Lawal, A., Watson, J., Strub-Wourgaft, N., & White, N. (2022). PLOS Global Public Health, 2(7).
Antimicrobial resistance patterns in bacteria causing febrile illness in Africa, South Asia, and Southeast Asia: a systematic review of published etiological studies from 1980-2015
Roberts, T., Dahal, P., Shrestha, P., Schilling, W., Shrestha, R., Ngu, R., Huong, V., van Doorn, H., Phimolsarnnousith, V., Miliya, T., Crump, J., Bell, D., Newton, P., Dittrich, S., Hopkins, H., Stepniewska, K., Guerin, P., Ashley, E., & Turner, P. (2022). International Journal of Infectious Diseases, 122.
Making data map-worthy-enhancing routine malaria data to support surveillance and mapping of Plasmodium falciparum anti-malarial resistance in a pre-elimination sub-Saharan African setting: a molecular and spatiotemporal epidemiology study.
Kagoro, F., Allen, E., Mabuza, A., Workman, L., Magagula, R., Kok, G., Davies, C., Malatje, G., Guérin, P., Dhorda, M., Maude, R., Raman, J., & Barnes, K. (2022). Malaria Journal, 21(1), 207.