Professor
Nicholas
White
Professor of Tropical Medicine
Nick White is a Professor of Tropical Medicine at Mahidol University Thailand and at the University of Oxford, and a consultant physician in acute general medicine at the John Radcliffe Hospital, Oxford, UK. He was Chair of the WWARN Board until 2016, and remains a member of the IDDO Board.
He also co-chaired the World Health Organization antimalarial treatment guidelines committee and the WHO Global Malaria Programme case management cluster. Prof White has served on the editorial advisory boards of international journals including The Lancet and PLoS Medicine. He has contributed to over 1000 peer reviewed scientific publications and has written over 50 book chapters.
Nick White began his work in Thailand in 1980 with the Wellcome Trust Mahidol Oxford Tropical Medicine Research Unit, a collaborative research programme between Mahidol and Oxford Universities. In 1986 he was appointed as Director of the Thailand Unit, and more recently Chair of the Wellcome Trust SE Asian Tropical Medicine Research Programmes.
Nick White’s contribution to tropical medicine and global health was recognised with a UK Knighthood in 2017. His research interests include the epidemiology, pathophysiology and treatment of malaria, melioidosis, typhoid, leptospirosis, dengue, haemorrhagic fever, Japanese encephalitis and tuberculosis.
All Publications
Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)
Jittamala, P., Boyd, S., Schilling, W., Watson, J., Ngamprasertchai, T., Siripoon, T., Luvira, V., Batty, E., Wongnak, P., Esper, L., Almeida, P., Cruz, C., Ascencao, F., Aguiar, R., Ghanchi, N., Callery, J., Singh, S., Kruabkontho, V., Ngernseng, T., … White, N. (2024). In medRxiv.
Rectal artesunate suppositories for the pre-referral treatment of suspected severe malaria
Watson, J., Peto, T., & White, N. (2023). PLoS Medicine, 20(11).
Effect of adherence to primaquine on the risk of Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Mehdipour, P., Rajasekhar, M., Dini, S., Zaloumis, S., Abreha, T., Adam, I., Awab, G., Baird, J., Brasil, L., Chu, C., Cui, L., Daher, A., do Socorro M Gomes, M., Gonzalez-Ceron, L., Hwang, J., Karunajeewa, H., Lacerda, M., Ladeia-Andrade, S., Leslie, T., … Commons, R. (2023). Malaria Journal, 22(1).
Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis
Commons, R., Rajasekhar, M., Edler, P., Abreha, T., Awab, G., Baird, J., Barber, B., Chu, C., Cui, L., Daher, A., Gonzalez-Ceron, L., Grigg, M., Hwang, J., Karunajeewa, H., Lacerda, M., Ladeia-Andrade, S., Lidia, K., Llanos-Cuentas, A., Longley, R., … Price, R. (2023). Lancet Infectious Diseases, 24(2), 172-183.
Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis
Rajasekhar, M., Simpson, J., Ley, B., Edler, P., Chu, C., Abreha, T., Awab, G., Baird, J., Bancone, G., Barber, B., Grigg, M., Hwang, J., Karunajeewa, H., Lacerda, M., Ladeia-Andrade, S., Llanos-Cuentas, A., Pukrittayakamee, S., Rijal, K., Saravu, K., … Price, R. (2023). Lancet Infectious Diseases, 24(2), 184-195.
Evidence based optimal dosing of intravenous artesunate in children with severe falciparum malaria
Haghiri, A., Price, D., Fitzpatrick, P., Dini, S., Rajasekhar, M., Fanello, C., Tarning, J., Watson, J., White, N., & Simpson, J. (2023). Clinical Pharmacology and Therapeutics.
Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study
Saito, M., Phyo, A., Chu, C., Proux, S., Rijken, M., Beau, C., Win, H., Archasuksan, L., Wiladphaingern, J., Phu, N., Hien, T., Day, N., Dondorp, A., White, N., Nosten, F., & McGready, R. (2023). BMC Medicine, 21.
Severe falciparum and vivax malaria on the Thailand-Myanmar border: a review of 1503 cases
Chu, C., Stolbrink, M., Stolady, D., Saito, M., Beau, C., Choun, K., Wah, T., Mu, N., Htoo, K., Nu, B., Keereevijit, A., Wiladpaingern, J., Carrara, V., Phyo, A., Lwin, K., Luxemburger, C., Proux, S., Charunwatthana, P., McGready, R., … Nosten, F. (2023). Clinical Infectious Diseases, 77(5), 721-728.
The CARAMAL study could not assess the effectiveness of rectal artesunate in treating suspected severe malaria
Watson, J., Peto, T., & White, N. (2023). BMC Medicine, 21(1).
Lineage-informative microhaplotypes for spatio-temporal surveillance of Plasmodium vivax malaria parasites.
Siegel, S., Amato, R., Trimarsanto, H., Sutanto, E., Kleinecke, M., Murie, K., Whitton, G., Taylor, A., Watson, J., Imwong, M., Assefa, A., Rahim, A., Chau, N., Hien, T., Green, J., Koh, G., White, N., Day, N., Kwiatkowski, D., … Auburn, S. (2023). MedRxiv, 4(03-29), 2023.03.13.23287179.
Pharmacometrics of high dose ivermectin in early COVID-19: an open label, randomized, controlled adaptive platform trial (PLATCOV)
Schilling, W., Jittamala, P., Watson, J., Ekkapongpisit, M., Siripoon, T., Ngamprasertchai, T., Luvira, V., Pongwilai, S., Cruz, C., Callery, J., Boyd, S., Kruabkontho, V., Ngernseng, T., Tubprasert, J., Abdad, M., Piaraksa, N., Suwannasin, K., Hanboonkunupakarn, P., Hanboonkunupakarn, B., … White, N. (2023). ELife, 12.
WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria
Peto, T., Watson, J., White, N., & Dondorp, A. (2023). Transactions of The Royal Society of Tropical Medicine and Hygiene, 117(7), 536-538.
Correction: A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?
Jittamala, P., Monteiro, W., Smit, M., Pedrique, B., Specht, S., Chaccour, C., Dard, C., Giudice, P., Khieu, V., Maruani, A., Failoc-Rojas, V., Sáez-de-Ocariz, M., Soriano-Arandes, A., Piquero-Casals, J., Faisant, A., Brenier-Pinchart, M.-P., Wimmersberger, D., Coulibaly, J., Keiser, J., … Kobylinski, K. (2023). PLoS Neglected Tropical Diseases, 17(1), e0011053.
Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open- label, randomised, controlled adaptive platform trial
Luvira, V., Schilling, W., Jittamala, P., Watson, J., Boyd, S., Siripoon, T., Ngamprasertchai, T., Almeida, P., Ekkapongpisit, M., Cruz, C., Callery, J., Singh, S., Tuntipaiboontana, R., Kruabkontho, V., Ngernseng, T., Tubprasert, J., Abdad, M., Keayarsa, S., Madmanee, W., … White, N. (2023). In Research Square.
Pharmacometric assessment of primaquine induced haemolysis in glucose-6-phosphate dehydrogenase deficiency
Pukrittayakamee, S., Jittamala, P., Watson, J., Hanboonkunupakarn, B., Leungsinsiri, P., Poovorawan, K., Chotivanich, K., Bancone, G., Chu, C., Imwong, M., Day, N., Taylor, W., & White, N. (2023). In medRxiv.
Environmental DNA as an innovative technique to identify the origins of falsified antimalarial tablets-a pilot study of the pharmabiome
Young, J., Liddicoat, C., van Dijk, K.-J., Tabernero, P., Caillet, C., White, N., Linacre, A., Austin, J., & Newton, P. (2022). Scientific Reports, 12(1), 21997.
Ten-year persistence and evolution of Plasmodium falciparum antifolate and anti-sulfonamide resistance markers pfdhfr and pfdhps in three Asian countries
Srisutham, S., Madmanee, W., Kouhathong, J., Sutawong, K., Tripura, R., Peto, T., van der Pluijm, R., Callery, J., Dysoley, L., Mayxay, M., Newton, P., Pongvongsa, T., Hongvanthong, B., Day, N., White, N., Dondorp, A., & Imwong, M. (2022). PLoS ONE, 17(12), e0278928.
The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: an individual patient data meta-analysis
Watson, J., Commons, R., Tarning, J., Simpson, J., Llanos Cuentas, A., Lacerda, M., Green, J., Koh, G., Chu, C., Nosten, F., Price, R., Day, N., & White, N. (2022). ELife, 11.
The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria
Srinamon, K., Watson, J., Silamut, K., Intharabut, B., Phu, N., Diep, P., Lyke, K., Fanello, C., von Seidlein, L., Chotivanich, K., Dondorp, A., Day, N., & White, N. (2022). Nature Communications, 13.
Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data
Stepniewska, K., Allen, E., Humphreys, G., Poirot, E., Craig, E., Kennon, K., Yilma, D., Bousema, T., Guerin, P., White, N., Price, R., Raman, J., Martensson, A., Mwaiswelo, R., Bancone, G., Bastiaens, G., Bjorkman, A., Brown, J., D’Alessandro, U., … Chen, I. (2022). BMC Medicine, 20.
Substantial misdiagnosis of severe malaria in African children.
White, N., Watson, J., Uyoga, S., Williams, T., & Maitland, K. (2022). Lancet (London, England), 400(10355), 807.
Higher-dose primaquine to prevent relapse of Plasmodium vivax malaria
Watson, J., & White, N. (2022). New England Journal of Medicine, 387(3), 282-283.
Definitions matter: heterogeneity of COVID-19 disease severity criteria and incomplete reporting compromise meta-analysis
Guérin, P., McLean, A., Rashan, S., Lawal, A., Watson, J., Strub-Wourgaft, N., & White, N. (2022). PLOS Global Public Health, 2(7).
Stopping prereferral rectal artesunate - a grave error
Watson, J., Warsame, M., Peto, T., Onyamboko, M., Fanello, C., Dondorp, A., & White, N. (2022). BMJ Global Health, 7(7).
Characterizing SARS-CoV-2 viral clearance kinetics to improve the design of antiviral pharmacometric studies
Watson, J., Kissler, S., Day, N., Grad, Y., & White, N. (2022). Antimicrobial Agents and Chemotherapy, 66(7).